Combination of multiparametric MRI and transperineal template‐guided mapping biopsy of the prostate to identify candidates for hemi‐ablative focal therapy
Objective To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mpMRI) and transperineal template‐guided mapping biopsy (TTMB) for identifying lobes with significant prostate cancer (PCa) for the application of hemi‐ablative focal therapy (FT). Patients and Methods From Ja...
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| Veröffentlicht in: | BJU international 2016-01, Vol.117 (1), p.48-54 |
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| creator | Tran, Minh Thompson, James Böhm, Maret Pulbrook, Marley Moses, Daniel Shnier, Ron Brenner, Phillip Delprado, Warick Haynes, Anne‐Maree Savdie, Richard Stricker, Phillip D. |
| description | Objective
To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mpMRI) and transperineal template‐guided mapping biopsy (TTMB) for identifying lobes with significant prostate cancer (PCa) for the application of hemi‐ablative focal therapy (FT).
Patients and Methods
From January 2012 to January 2014, 89 consecutive patients, aged ≥40 years, with a PSA level ≤15 ng/mL, underwent in sequential order: mpMRI, TTMB and radical prostatectomy (RP) at a single centre. Analysis was performed on 50 patients who met consensus guidelines for FT. Lobes were stratified into lobes with significant cancer (LSC), lobes with insignificant cancer and lobes with no cancer. Using histopathology at RP, the predictive performance of combined mpMRI + TTMB in identifying LSC was evaluated.
Results
The sensitivity, specificity and positive predictive value for mpMRI + TTMB for LSC were 97, 61 and 83%, respectively. The negative predictive value (NPV), the primary variable of interest, for mpMRI + TTMB for LSC was 91%. Of the 50 patients, 21 had significant unilateral disease on mpMRI + TTMB. Two of these 21 patients had significant bilateral disease on RP not identified on mpMRI + TTMB.
Conclusions
In the selection of candidates for FT, a combination of mpMRI and TTMB provides a high NPV in the detection of LSC. |
| doi_str_mv | 10.1111/bju.13090 |
| format | Article |
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To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mpMRI) and transperineal template‐guided mapping biopsy (TTMB) for identifying lobes with significant prostate cancer (PCa) for the application of hemi‐ablative focal therapy (FT).
Patients and Methods
From January 2012 to January 2014, 89 consecutive patients, aged ≥40 years, with a PSA level ≤15 ng/mL, underwent in sequential order: mpMRI, TTMB and radical prostatectomy (RP) at a single centre. Analysis was performed on 50 patients who met consensus guidelines for FT. Lobes were stratified into lobes with significant cancer (LSC), lobes with insignificant cancer and lobes with no cancer. Using histopathology at RP, the predictive performance of combined mpMRI + TTMB in identifying LSC was evaluated.
Results
The sensitivity, specificity and positive predictive value for mpMRI + TTMB for LSC were 97, 61 and 83%, respectively. The negative predictive value (NPV), the primary variable of interest, for mpMRI + TTMB for LSC was 91%. Of the 50 patients, 21 had significant unilateral disease on mpMRI + TTMB. Two of these 21 patients had significant bilateral disease on RP not identified on mpMRI + TTMB.
Conclusions
In the selection of candidates for FT, a combination of mpMRI and TTMB provides a high NPV in the detection of LSC.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/bju.13090</identifier><identifier>PMID: 25682968</identifier><identifier>CODEN: BJINFO</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; Biopsy - methods ; Diagnosis, Computer-Assisted ; focal therapy ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; MRI ; Prostate - pathology ; Prostate cancer ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Sensitivity and Specificity ; transperineal template‐guided mapping biopsy</subject><ispartof>BJU international, 2016-01, Vol.117 (1), p.48-54</ispartof><rights>2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd</rights><rights>2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.</rights><rights>BJUI © 2016 BJU International</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4580-4db64185693e56ca1af9321e11b0f9ac1ddab8fe50a1055cdd604d47f487c04b3</citedby><cites>FETCH-LOGICAL-c4580-4db64185693e56ca1af9321e11b0f9ac1ddab8fe50a1055cdd604d47f487c04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbju.13090$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbju.13090$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25682968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Minh</creatorcontrib><creatorcontrib>Thompson, James</creatorcontrib><creatorcontrib>Böhm, Maret</creatorcontrib><creatorcontrib>Pulbrook, Marley</creatorcontrib><creatorcontrib>Moses, Daniel</creatorcontrib><creatorcontrib>Shnier, Ron</creatorcontrib><creatorcontrib>Brenner, Phillip</creatorcontrib><creatorcontrib>Delprado, Warick</creatorcontrib><creatorcontrib>Haynes, Anne‐Maree</creatorcontrib><creatorcontrib>Savdie, Richard</creatorcontrib><creatorcontrib>Stricker, Phillip D.</creatorcontrib><title>Combination of multiparametric MRI and transperineal template‐guided mapping biopsy of the prostate to identify candidates for hemi‐ablative focal therapy</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>Objective
To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mpMRI) and transperineal template‐guided mapping biopsy (TTMB) for identifying lobes with significant prostate cancer (PCa) for the application of hemi‐ablative focal therapy (FT).
Patients and Methods
From January 2012 to January 2014, 89 consecutive patients, aged ≥40 years, with a PSA level ≤15 ng/mL, underwent in sequential order: mpMRI, TTMB and radical prostatectomy (RP) at a single centre. Analysis was performed on 50 patients who met consensus guidelines for FT. Lobes were stratified into lobes with significant cancer (LSC), lobes with insignificant cancer and lobes with no cancer. Using histopathology at RP, the predictive performance of combined mpMRI + TTMB in identifying LSC was evaluated.
Results
The sensitivity, specificity and positive predictive value for mpMRI + TTMB for LSC were 97, 61 and 83%, respectively. The negative predictive value (NPV), the primary variable of interest, for mpMRI + TTMB for LSC was 91%. Of the 50 patients, 21 had significant unilateral disease on mpMRI + TTMB. Two of these 21 patients had significant bilateral disease on RP not identified on mpMRI + TTMB.
Conclusions
In the selection of candidates for FT, a combination of mpMRI and TTMB provides a high NPV in the detection of LSC.</description><subject>Biopsy</subject><subject>Biopsy - methods</subject><subject>Diagnosis, Computer-Assisted</subject><subject>focal therapy</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>MRI</subject><subject>Prostate - pathology</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Sensitivity and Specificity</subject><subject>transperineal template‐guided mapping biopsy</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9u1DAUhyMEoqWw4ALIEhu6mNaeOB5nCaOWFhUhISqxi_znueNRnBjbAWXXI3ADOAtH6Ul4ZVoWSHhj66dPn5_er6qeM3rE8Bzr7XTEatrSB9U-44IvOKOfH96_aSv2qic5bynFQDSPq71lI-SyFXK_-rEeg_aDKn4cyOhImPrio0oqQEnekPcfz4kaLClJDTlC8gOonhQIsVcFbq6_X03egiVBxeiHK6L9GPOMpl8_ywZITGMuCJIyEuSG4t1MDAq9xTQTNyaygeBRpDQa_VfAzNx-sYGk4vy0euRUn-HZ3X1QXZ6efFqfLS4-vD1fv75YGN5IuuBWC85kI9oaGmEUU66tlwwY09S1yjBrlZYOGqoYbRpjraDc8pXjcmUo1_VB9WrnxYm_TJBLF3w20PdqgHHKHVs1lNc15StEX_6DbscpDTgdUrxdSilpjdThjjK4gpzAdTH5oNLcMdrdttZha92f1pB9cWecdAD7l7yvCYHjHfDN9zD_39S9eXe5U_4GcPanSg</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Tran, Minh</creator><creator>Thompson, James</creator><creator>Böhm, Maret</creator><creator>Pulbrook, Marley</creator><creator>Moses, Daniel</creator><creator>Shnier, Ron</creator><creator>Brenner, Phillip</creator><creator>Delprado, Warick</creator><creator>Haynes, Anne‐Maree</creator><creator>Savdie, Richard</creator><creator>Stricker, Phillip D.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Combination of multiparametric MRI and transperineal template‐guided mapping biopsy of the prostate to identify candidates for hemi‐ablative focal therapy</title><author>Tran, Minh ; Thompson, James ; Böhm, Maret ; Pulbrook, Marley ; Moses, Daniel ; Shnier, Ron ; Brenner, Phillip ; Delprado, Warick ; Haynes, Anne‐Maree ; Savdie, Richard ; Stricker, Phillip D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4580-4db64185693e56ca1af9321e11b0f9ac1ddab8fe50a1055cdd604d47f487c04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biopsy</topic><topic>Biopsy - methods</topic><topic>Diagnosis, Computer-Assisted</topic><topic>focal therapy</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>MRI</topic><topic>Prostate - pathology</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Sensitivity and Specificity</topic><topic>transperineal template‐guided mapping biopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran, Minh</creatorcontrib><creatorcontrib>Thompson, James</creatorcontrib><creatorcontrib>Böhm, Maret</creatorcontrib><creatorcontrib>Pulbrook, Marley</creatorcontrib><creatorcontrib>Moses, Daniel</creatorcontrib><creatorcontrib>Shnier, Ron</creatorcontrib><creatorcontrib>Brenner, Phillip</creatorcontrib><creatorcontrib>Delprado, Warick</creatorcontrib><creatorcontrib>Haynes, Anne‐Maree</creatorcontrib><creatorcontrib>Savdie, Richard</creatorcontrib><creatorcontrib>Stricker, Phillip D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Minh</au><au>Thompson, James</au><au>Böhm, Maret</au><au>Pulbrook, Marley</au><au>Moses, Daniel</au><au>Shnier, Ron</au><au>Brenner, Phillip</au><au>Delprado, Warick</au><au>Haynes, Anne‐Maree</au><au>Savdie, Richard</au><au>Stricker, Phillip D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination of multiparametric MRI and transperineal template‐guided mapping biopsy of the prostate to identify candidates for hemi‐ablative focal therapy</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2016-01</date><risdate>2016</risdate><volume>117</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><coden>BJINFO</coden><abstract>Objective
To evaluate the accuracy of combined multiparametric magnetic resonance imaging (mpMRI) and transperineal template‐guided mapping biopsy (TTMB) for identifying lobes with significant prostate cancer (PCa) for the application of hemi‐ablative focal therapy (FT).
Patients and Methods
From January 2012 to January 2014, 89 consecutive patients, aged ≥40 years, with a PSA level ≤15 ng/mL, underwent in sequential order: mpMRI, TTMB and radical prostatectomy (RP) at a single centre. Analysis was performed on 50 patients who met consensus guidelines for FT. Lobes were stratified into lobes with significant cancer (LSC), lobes with insignificant cancer and lobes with no cancer. Using histopathology at RP, the predictive performance of combined mpMRI + TTMB in identifying LSC was evaluated.
Results
The sensitivity, specificity and positive predictive value for mpMRI + TTMB for LSC were 97, 61 and 83%, respectively. The negative predictive value (NPV), the primary variable of interest, for mpMRI + TTMB for LSC was 91%. Of the 50 patients, 21 had significant unilateral disease on mpMRI + TTMB. Two of these 21 patients had significant bilateral disease on RP not identified on mpMRI + TTMB.
Conclusions
In the selection of candidates for FT, a combination of mpMRI and TTMB provides a high NPV in the detection of LSC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>25682968</pmid><doi>10.1111/bju.13090</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BJU international, 2016-01, Vol.117 (1), p.48-54 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Biopsy Biopsy - methods Diagnosis, Computer-Assisted focal therapy Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male MRI Prostate - pathology Prostate cancer Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Sensitivity and Specificity transperineal template‐guided mapping biopsy |
| title | Combination of multiparametric MRI and transperineal template‐guided mapping biopsy of the prostate to identify candidates for hemi‐ablative focal therapy |
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