Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene
The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skii...
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| Veröffentlicht in: | Biochimie 2015-12, Vol.119, p.1-5 |
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| creator | Hermine, Olivier Dine, Gérard Genty, Vincent Marquet, Laurie-Anne Fumagalli, Gabriela Tafflet, Muriel Guillem, Flavia Van Lierde, Françoise Rousseaux-Blanchi, Marie-Philippe Palierne, Christian Lapostolle, Jean-Claude Cervetti, Jean-Pierre Frey, Alain Jouven, Xavier Noirez, Philippe Toussaint, Jean-François |
| description | The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.
•The frequency of HFE mutations in elite athletes is twice as high as in controls.•In the international podium group, 80% of athletes have mutations in the HFE gene.•The HFE mutations are favourable to high level performance in athletes.•Heterozygous HFE mutations could be associated with a favourable phenotype. |
| doi_str_mv | 10.1016/j.biochi.2015.09.028 |
| format | Article |
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•The frequency of HFE mutations in elite athletes is twice as high as in controls.•In the international podium group, 80% of athletes have mutations in the HFE gene.•The HFE mutations are favourable to high level performance in athletes.•Heterozygous HFE mutations could be associated with a favourable phenotype.</description><identifier>ISSN: 0300-9084</identifier><identifier>EISSN: 1638-6183</identifier><identifier>DOI: 10.1016/j.biochi.2015.09.028</identifier><identifier>PMID: 26416567</identifier><language>eng</language><publisher>France: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Alleles ; Amino Acid Substitution ; Athlete ; Athletes ; Athletic Performance ; Female ; France ; Gene ; Gene Frequency ; Genetic Association Studies ; Hemochromatosis Protein - genetics ; Hemochromatosis Protein - metabolism ; Heterozygote ; HFE mutation frequency ; Humans ; Iron ; Male ; Martial Arts ; Middle Aged ; Muscle Development - genetics ; Mutation ; Physical Endurance - genetics ; Skiing ; Young Adult</subject><ispartof>Biochimie, 2015-12, Vol.119, p.1-5</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-36a5be080552b48e68fe0776e748db3f0c689d8a45c86e6c62be5f662b7023863</citedby><cites>FETCH-LOGICAL-c428t-36a5be080552b48e68fe0776e748db3f0c689d8a45c86e6c62be5f662b7023863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biochi.2015.09.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26416567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermine, Olivier</creatorcontrib><creatorcontrib>Dine, Gérard</creatorcontrib><creatorcontrib>Genty, Vincent</creatorcontrib><creatorcontrib>Marquet, Laurie-Anne</creatorcontrib><creatorcontrib>Fumagalli, Gabriela</creatorcontrib><creatorcontrib>Tafflet, Muriel</creatorcontrib><creatorcontrib>Guillem, Flavia</creatorcontrib><creatorcontrib>Van Lierde, Françoise</creatorcontrib><creatorcontrib>Rousseaux-Blanchi, Marie-Philippe</creatorcontrib><creatorcontrib>Palierne, Christian</creatorcontrib><creatorcontrib>Lapostolle, Jean-Claude</creatorcontrib><creatorcontrib>Cervetti, Jean-Pierre</creatorcontrib><creatorcontrib>Frey, Alain</creatorcontrib><creatorcontrib>Jouven, Xavier</creatorcontrib><creatorcontrib>Noirez, Philippe</creatorcontrib><creatorcontrib>Toussaint, Jean-François</creatorcontrib><title>Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene</title><title>Biochimie</title><addtitle>Biochimie</addtitle><description>The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.
•The frequency of HFE mutations in elite athletes is twice as high as in controls.•In the international podium group, 80% of athletes have mutations in the HFE gene.•The HFE mutations are favourable to high level performance in athletes.•Heterozygous HFE mutations could be associated with a favourable phenotype.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Amino Acid Substitution</subject><subject>Athlete</subject><subject>Athletes</subject><subject>Athletic Performance</subject><subject>Female</subject><subject>France</subject><subject>Gene</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Hemochromatosis Protein - genetics</subject><subject>Hemochromatosis Protein - metabolism</subject><subject>Heterozygote</subject><subject>HFE mutation frequency</subject><subject>Humans</subject><subject>Iron</subject><subject>Male</subject><subject>Martial Arts</subject><subject>Middle Aged</subject><subject>Muscle Development - genetics</subject><subject>Mutation</subject><subject>Physical Endurance - genetics</subject><subject>Skiing</subject><subject>Young Adult</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVpaTZp_0EpOvZQOyPbkuVLoYTdJBDIpaVHIcvjWIttuZKcstf-8io46TGn4cF782Y-Qj4xyBkwcXnMW-vMYPMCGM-hyaGQb8iOiVJmgsnyLdlBCZA1IKszch7CEQA4FM17claIigku6h35u7cPQzzRBb3BOVLX04PH2Qw0LM5H-sfOM_pA7Uzvx9O0WPOV_nJ-7KieO7pfvVtQz4EaNy0YbbQuiUE_Ip3WqDeZsnFAOuCU7vVu0tEFG-jNYU8fcMYP5F2vx4Afn-cF-XnY_7i6ye7ur2-vvt9lpipkzEqheYsggfOirSQK2SPUtcC6kl1b9mCEbDqpK26kQGFE0SLvRRo1FKUU5QX5su1dvPu9YohqssHgOOoZ3RoUqzlUZVGKJlmrzWq8C8FjrxZvJ-1PioF6oq-OaqOvnugraFSin2KfnxvWdsLuf-gFdzJ82wyY_ny06FUwNtHGzno0UXXOvt7wDzxrmTM</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Hermine, Olivier</creator><creator>Dine, Gérard</creator><creator>Genty, Vincent</creator><creator>Marquet, Laurie-Anne</creator><creator>Fumagalli, Gabriela</creator><creator>Tafflet, Muriel</creator><creator>Guillem, Flavia</creator><creator>Van Lierde, Françoise</creator><creator>Rousseaux-Blanchi, Marie-Philippe</creator><creator>Palierne, Christian</creator><creator>Lapostolle, Jean-Claude</creator><creator>Cervetti, Jean-Pierre</creator><creator>Frey, Alain</creator><creator>Jouven, Xavier</creator><creator>Noirez, Philippe</creator><creator>Toussaint, Jean-François</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene</title><author>Hermine, Olivier ; Dine, Gérard ; Genty, Vincent ; Marquet, Laurie-Anne ; Fumagalli, Gabriela ; Tafflet, Muriel ; Guillem, Flavia ; Van Lierde, Françoise ; Rousseaux-Blanchi, Marie-Philippe ; Palierne, Christian ; Lapostolle, Jean-Claude ; Cervetti, Jean-Pierre ; Frey, Alain ; Jouven, Xavier ; Noirez, Philippe ; Toussaint, Jean-François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-36a5be080552b48e68fe0776e748db3f0c689d8a45c86e6c62be5f662b7023863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Amino Acid Substitution</topic><topic>Athlete</topic><topic>Athletes</topic><topic>Athletic Performance</topic><topic>Female</topic><topic>France</topic><topic>Gene</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Hemochromatosis Protein - genetics</topic><topic>Hemochromatosis Protein - metabolism</topic><topic>Heterozygote</topic><topic>HFE mutation frequency</topic><topic>Humans</topic><topic>Iron</topic><topic>Male</topic><topic>Martial Arts</topic><topic>Middle Aged</topic><topic>Muscle Development - genetics</topic><topic>Mutation</topic><topic>Physical Endurance - genetics</topic><topic>Skiing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermine, Olivier</creatorcontrib><creatorcontrib>Dine, Gérard</creatorcontrib><creatorcontrib>Genty, Vincent</creatorcontrib><creatorcontrib>Marquet, Laurie-Anne</creatorcontrib><creatorcontrib>Fumagalli, Gabriela</creatorcontrib><creatorcontrib>Tafflet, Muriel</creatorcontrib><creatorcontrib>Guillem, Flavia</creatorcontrib><creatorcontrib>Van Lierde, Françoise</creatorcontrib><creatorcontrib>Rousseaux-Blanchi, Marie-Philippe</creatorcontrib><creatorcontrib>Palierne, Christian</creatorcontrib><creatorcontrib>Lapostolle, Jean-Claude</creatorcontrib><creatorcontrib>Cervetti, Jean-Pierre</creatorcontrib><creatorcontrib>Frey, Alain</creatorcontrib><creatorcontrib>Jouven, Xavier</creatorcontrib><creatorcontrib>Noirez, Philippe</creatorcontrib><creatorcontrib>Toussaint, Jean-François</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermine, Olivier</au><au>Dine, Gérard</au><au>Genty, Vincent</au><au>Marquet, Laurie-Anne</au><au>Fumagalli, Gabriela</au><au>Tafflet, Muriel</au><au>Guillem, Flavia</au><au>Van Lierde, Françoise</au><au>Rousseaux-Blanchi, Marie-Philippe</au><au>Palierne, Christian</au><au>Lapostolle, Jean-Claude</au><au>Cervetti, Jean-Pierre</au><au>Frey, Alain</au><au>Jouven, Xavier</au><au>Noirez, Philippe</au><au>Toussaint, Jean-François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>2015-12</date><risdate>2015</risdate><volume>119</volume><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><abstract>The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.
•The frequency of HFE mutations in elite athletes is twice as high as in controls.•In the international podium group, 80% of athletes have mutations in the HFE gene.•The HFE mutations are favourable to high level performance in athletes.•Heterozygous HFE mutations could be associated with a favourable phenotype.</abstract><cop>France</cop><pub>Elsevier B.V</pub><pmid>26416567</pmid><doi>10.1016/j.biochi.2015.09.028</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Alleles Amino Acid Substitution Athlete Athletes Athletic Performance Female France Gene Gene Frequency Genetic Association Studies Hemochromatosis Protein - genetics Hemochromatosis Protein - metabolism Heterozygote HFE mutation frequency Humans Iron Male Martial Arts Middle Aged Muscle Development - genetics Mutation Physical Endurance - genetics Skiing Young Adult |
| title | Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene |
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