Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells

We investigated whether altering Warburg metabolism (aerobic glycolysis) by treatment with the metabolic agent dichloroacetate (DCA) could increase the X-ray-induced cell killing of the radiation-resistant human non-small-cell lung cancer (NSCLC) cell lines A549 and H1299. Treatment with 50mM DCA de...

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Veröffentlicht in:	Free radical biology & medicine 2015-12, Vol.89, p.263-273
Hauptverfasser:	Tan Allen, Kah, Chin-Sinex, Helen, DeLuca, Thomas, Pomerening, Joseph R., Sherer, Jeremy, Watkins, John B., Foley, John, Jesseph, Jerry M., Mendonca, Marc S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Cell Cycle - drug effects Cell Cycle - radiation effects Cell Proliferation - drug effects Cell Proliferation - radiation effects Comet Assay Dichloroacetate (DCA) Dichloroacetic Acid - pharmacology DNA Breaks, Double-Stranded - drug effects DNA Breaks, Double-Stranded - radiation effects DNA Repair - drug effects DNA Repair - radiation effects Double-strand DNA break repair Fractionated/split-dose Glycolysis - drug effects Glycolysis - physiology Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Non-small cell lung cancer (NSCLC) Radiation Tolerance - drug effects Tumor Cells, Cultured Warburg effect X-Rays
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