Synthesis and biological evaluation of novel lipoamino acid derivatives

[Display omitted] Seven novel lipoamino acid conjugates were synthesized from methyl oleate and amino acids. Methyl oleate was grafted to different amino acids using thioglycolic acid as a spacer group. Seven derivatives (3a–g) were prepared and characterized by spectral data (NMR, IR and MS spectra...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2016-01, Vol.26 (1), p.209-212
Hauptverfasser:	Kaki, Shiva Shanker, Arukali, Sammaiah, Korlipara, Padmaja V., Prasad, R.B.N., Yedla, Poornachandra, Ganesh Kumar, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid Amino Acids - chemical synthesis Amino Acids - chemistry Amino Acids - pharmacology Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiofilm activity Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biofilms - drug effects Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fatty acid Fungi - drug effects Gram-Positive Bacteria - drug effects Hep G2 Cells Humans Lipoamino acid Microbial Sensitivity Tests Molecular Structure Oleic Acids - chemical synthesis Oleic Acids - chemistry Oleic Acids - pharmacology Structure-Activity Relationship Thioglycolates - chemistry
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