p53 Regulates the Expression of the Tumor Suppressor Gene Maspin

Maspin has been shown to inhibit tumor cell invasion and metastasis in breast tumor cells. Maspin expression was detected in normal breast and prostate epithelial cells, whereas tumor cells exhibited reduced or no expression. However, the regulatory mechanism of maspin expression remains unknown. We...

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Veröffentlicht in:	The Journal of biological chemistry 2000-03, Vol.275 (9), p.6051-6054
Hauptverfasser:	Zou, Zhiqiang, Gao, Chunling, Nagaich, Akhilesh K., Connell, Theresa, Saito, Shin'ichi, Moul, Judd W., Seth, Prem, Appella, Ettore, Srivastava, Shiv
Format:	Artikel
Sprache:	eng
Schlagworte:	adeno-associated virus Adenoviridae - genetics Antineoplastic Agents - pharmacology Breast Neoplasms - metabolism DNA Damage - drug effects DNA Damage - radiation effects DNA-Binding Proteins - metabolism Etoposide - pharmacology Gene Expression Regulation Gene Expression Regulation, Neoplastic - drug effects Genes, Tumor Suppressor - drug effects Humans Male maspin Neoplasm Metastasis Promoter Regions, Genetic Prostatic Neoplasms - metabolism Proteins - pharmacology RNA, Messenger - metabolism Serpins - pharmacology Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ultraviolet Rays
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