Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1

Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 ( YY1 ) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo . Gain or loss of func...

Ausführliche Beschreibung