The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D2 receptor occupancy and stimulus generalization to a d-amphetamine cue

The etiology of schizophrenia is poorly understood and two principle hypotheses have dominated the field. Firstly, that subcortical dopamine function is enhanced while cortical dopamine function is reduced and secondly, that cortical glutamate systems are dysfunctional. It is also widely accepted th...

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Veröffentlicht in:	Neuropharmacology 2016-02, Vol.101, p.24-35
Hauptverfasser:	Hutson, Peter H., Rowley, Helen L., Gosden, James, Kulkarni, Rajiv S., Slater, Nigel, Love, Patrick L., Wang, Yiyun, Heal, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Analysis of Variance Animals Benzodiazepines - pharmacology Central Nervous System Stimulants - pharmacology Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - metabolism Cues Dopamine - metabolism Dopamine Antagonists - pharmacology Dopamine D2 receptor occupancy Dopamine efflux Drug discrimination Generalization, Stimulus Limbic System - drug effects Lisdexamfetamine Lisdexamfetamine Dimesylate - pharmacology Male Nucleus accumbens Prefrontal cortex Raclopride - pharmacology Rats Rats, Sprague-Dawley Receptors, Dopamine D2 - metabolism Tandem Mass Spectrometry Time Factors
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