Mucosal vaccination and immune responses in the elderly

To develop a mucosal vaccine strategy for the elderly, we have compared mucosal and systemic immune responses between aged (12–14 months) and young adult (8–12 weeks) mice. Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 μg of cholera toxin as a...

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Veröffentlicht in:	Vaccine 2000-02, Vol.18 (16), p.1675-1680
Hauptverfasser:	Fujihashi, Kohtaro, Koga, Toshiya, McGhee, Jerry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Oral Aging - immunology Animals Applied microbiology B-Lymphocytes - immunology Bacterial Toxins - administration & dosage Biological and medical sciences Cholera Toxin - administration & dosage Elderly Enterotoxins - administration & dosage Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Immunity, Mucosal Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Mice Microbiology Mucosa ovalbumin Ovalbumin - administration & dosage Ovalbumin - immunology Th1 Cells - immunology Th2 Cells - immunology Vaccination Vaccination - methods Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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