Mucosal vaccination and immune responses in the elderly
To develop a mucosal vaccine strategy for the elderly, we have compared mucosal and systemic immune responses between aged (12–14 months) and young adult (8–12 weeks) mice. Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 μg of cholera toxin as a...
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| Veröffentlicht in: | Vaccine 2000-02, Vol.18 (16), p.1675-1680 |
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| creator | Fujihashi, Kohtaro Koga, Toshiya McGhee, Jerry R. |
| description | To develop a mucosal vaccine strategy for the elderly, we have compared mucosal and systemic immune responses between aged (12–14 months) and young adult (8–12 weeks) mice. Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 μg of cholera toxin as adjuvant. Although elevated levels of OVA-specific systemic IgG and mucosal IgA Ab responses were seen in young mice, aged mice showed impaired antigen-specific mucosal and systemic immune responses. These results suggest that mucosal immunity is down regulated in aged mice. |
| doi_str_mv | 10.1016/S0264-410X(99)00505-8 |
| format | Article |
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Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 μg of cholera toxin as adjuvant. Although elevated levels of OVA-specific systemic IgG and mucosal IgA Ab responses were seen in young mice, aged mice showed impaired antigen-specific mucosal and systemic immune responses. These results suggest that mucosal immunity is down regulated in aged mice.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(99)00505-8</identifier><identifier>PMID: 10689147</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Administration, Oral ; Aging - immunology ; Animals ; Applied microbiology ; B-Lymphocytes - immunology ; Bacterial Toxins - administration & dosage ; Biological and medical sciences ; Cholera Toxin - administration & dosage ; Elderly ; Enterotoxins - administration & dosage ; Escherichia coli Proteins ; Fundamental and applied biological sciences. 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These results suggest that mucosal immunity is down regulated in aged mice.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Administration, Oral</subject><subject>Aging - immunology</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacterial Toxins - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cholera Toxin - administration & dosage</subject><subject>Elderly</subject><subject>Enterotoxins - administration & dosage</subject><subject>Escherichia coli Proteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Mucosa</subject><subject>ovalbumin</subject><subject>Ovalbumin - administration & dosage</subject><subject>Ovalbumin - immunology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Vaccination</subject><subject>Vaccination - methods</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKxDAUgOEgijOOPoLShYguqrk2zUpk8AYjLlRwF9L0FCNtOibtwLy9nQvqztXZfCc5_AgdE3xJMMmuXjDNeMoJfj9X6gJjgUWa76AxySVLqSD5Lhr_kBE6iPETD4oRtY9GBGe5IlyOkXzqbRtNnSyMtc6bzrU-Mb5MXNP0HpIAcd76CDFxPuk-IIG6hFAvD9FeZeoIR9s5QW93t6_Th3T2fP84vZmllkvWpZmSghaFYQVhhOMSaFFSApxnVhpmM1kVRnBRMCNpVlGRS5Px3FCheFWVvGITdLZ5dx7arx5ipxsXLdS18dD2URPJlVKMDlBsoA1tjAEqPQ-uMWGpCdarYnpdTK9yaKX0upjOh72T7Qd90UD5Z2uTaACnW2CiNXUVjLcu_jqOJWF4YNcbBkONhYOgo3XgLZQugO102bp_LvkGOM-HPQ</recordid><startdate>20000225</startdate><enddate>20000225</enddate><creator>Fujihashi, Kohtaro</creator><creator>Koga, Toshiya</creator><creator>McGhee, Jerry R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20000225</creationdate><title>Mucosal vaccination and immune responses in the elderly</title><author>Fujihashi, Kohtaro ; Koga, Toshiya ; McGhee, Jerry R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-69752bba3b13140de2bd21e446c7a3c67fba545b3a726f2587a648a2594ffd4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Administration, Oral</topic><topic>Aging - immunology</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacterial Toxins - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cholera Toxin - administration & dosage</topic><topic>Elderly</topic><topic>Enterotoxins - administration & dosage</topic><topic>Escherichia coli Proteins</topic><topic>Fundamental and applied biological sciences. 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| issn | 0264-410X 1873-2518 |
| language | eng |
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| subjects | Adjuvants, Immunologic - administration & dosage Administration, Oral Aging - immunology Animals Applied microbiology B-Lymphocytes - immunology Bacterial Toxins - administration & dosage Biological and medical sciences Cholera Toxin - administration & dosage Elderly Enterotoxins - administration & dosage Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Immunity, Mucosal Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Mice Microbiology Mucosa ovalbumin Ovalbumin - administration & dosage Ovalbumin - immunology Th1 Cells - immunology Th2 Cells - immunology Vaccination Vaccination - methods Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Mucosal vaccination and immune responses in the elderly |
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