Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation
BACKGROUND—There are a paucity of data regarding the long-term natural history of adult Wolff-Parkinson-White (WPW) syndrome patients in regard to risk of mortality and atrial fibrillation (AF). We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the...
Gespeichert in:
| Veröffentlicht in: | Circulation. Arrhythmia and electrophysiology 2015-12, Vol.Publish Ahead of Print (6), p.1465-1471 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1471 |
|---|---|
| container_issue | 6 |
| container_start_page | 1465 |
| container_title | Circulation. Arrhythmia and electrophysiology |
| container_volume | Publish Ahead of Print |
| creator | Bunch, T Jared May, Heidi T Bair, Tami L Anderson, Jeffrey L Crandall, Brian G Cutler, Michael J Jacobs, Victoria Mallender, Charles Muhlestein, Joseph B Osborn, Jeffrey S Weiss, J Peter Day, John D |
| description | BACKGROUND—There are a paucity of data regarding the long-term natural history of adult Wolff-Parkinson-White (WPW) syndrome patients in regard to risk of mortality and atrial fibrillation (AF). We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the natural history.
METHODS AND RESULTS—Three groups of patients were studied2 WPW populations (Ablation872, No Ablation1461) and a 1:5 control population (n=11,175). Long-term mortality and AF rates were determined. The average follow-up for the WPW group was 7.9 ± 5.9 (median6.9) years and was similar between the ablation and non-ablation groups. Death rates were similar between the WPW group versus the control group [HR=0.96 (95% CI0.83-1.11), p=0.56]. Non-ablated WPW patients had a higher long-term death risk compared to WPW ablation patients [HR=2.10 (95% CI1.50-20.93), p |
| doi_str_mv | 10.1161/CIRCEP.115.003013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1749992104</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1749992104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3923-c63ad2e83be4999bad949dac512878ccde9031bffe5095eb5cd5f53e92c0d41d3</originalsourceid><addsrcrecordid>eNp9kEFP3DAQhS1UBJT2B_RS-diLwY7tEB9XERSkVVnRrThGjj1pUpyY2o5W--_rVZYemcu8w_eeZh5CXxi9Yqxk1_XDU327yVpeUcop4yfoginBCKeV-PCmmVDn6GOMfygtWcXKM3RelKKiitMLNK_99JtsIYz4h05z0A7fDzH5sMe-wys7u4Sfves6stHhZZiin8hzPyTAP_eTDX4EvNFpgClFvA2gE1i8G1KP9bQIPydc69RDgoBXrcuwnz6h0067CJ-P-xL9urvd1vdk_fj9oV6tieGq4MSUXNsCKt6CUEq12iqhrDaSFdVNZYwFRTlruw4kVRJaaazsJAdVGGoFs_wSfVtyX4P_O0NMzThEA87pCfwcG3ZzyC0YFRllC2qCjzFA17yGYdRh3zDaHNpulrazls3SdvZ8PcbP7Qj2v-Ot3gzIBdh5l_-PL27eQWh60C717waLd3wHIh_OiaLHIfmJivJ_H-CdYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749992104</pqid></control><display><type>article</type><title>Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>American Heart Association</source><creator>Bunch, T Jared ; May, Heidi T ; Bair, Tami L ; Anderson, Jeffrey L ; Crandall, Brian G ; Cutler, Michael J ; Jacobs, Victoria ; Mallender, Charles ; Muhlestein, Joseph B ; Osborn, Jeffrey S ; Weiss, J Peter ; Day, John D</creator><creatorcontrib>Bunch, T Jared ; May, Heidi T ; Bair, Tami L ; Anderson, Jeffrey L ; Crandall, Brian G ; Cutler, Michael J ; Jacobs, Victoria ; Mallender, Charles ; Muhlestein, Joseph B ; Osborn, Jeffrey S ; Weiss, J Peter ; Day, John D</creatorcontrib><description>BACKGROUND—There are a paucity of data regarding the long-term natural history of adult Wolff-Parkinson-White (WPW) syndrome patients in regard to risk of mortality and atrial fibrillation (AF). We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the natural history.
METHODS AND RESULTS—Three groups of patients were studied2 WPW populations (Ablation872, No Ablation1461) and a 1:5 control population (n=11,175). Long-term mortality and AF rates were determined. The average follow-up for the WPW group was 7.9 ± 5.9 (median6.9) years and was similar between the ablation and non-ablation groups. Death rates were similar between the WPW group versus the control group [HR=0.96 (95% CI0.83-1.11), p=0.56]. Non-ablated WPW patients had a higher long-term death risk compared to WPW ablation patients [HR=2.10 (95% CI1.50-20.93), p<0.0001). Incident AF risk was higher in the WPW group compared to the control population [HR=1.55 (95% CI1.29-1.87), p<0.0001]. Non-ablated WPW patients had lower risk than ablated patients [HR=0.39 (95% CI0.28-0.53), p<0.0001).
CONCLUSIONS—Long-term mortality rates in WPW patients are low and similar to an age- and gender-matched control population. AF rates are high long-term and ablation does not reduce this risk.</description><identifier>ISSN: 1941-3149</identifier><identifier>EISSN: 1941-3084</identifier><identifier>DOI: 10.1161/CIRCEP.115.003013</identifier><identifier>PMID: 26480930</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adult ; Age Factors ; Aged ; Atrial Fibrillation - epidemiology ; Catheter Ablation ; Female ; Humans ; Idaho - epidemiology ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Utah - epidemiology ; Wolff-Parkinson-White Syndrome - diagnosis ; Wolff-Parkinson-White Syndrome - mortality ; Wolff-Parkinson-White Syndrome - physiopathology ; Wolff-Parkinson-White Syndrome - surgery ; Young Adult</subject><ispartof>Circulation. Arrhythmia and electrophysiology, 2015-12, Vol.Publish Ahead of Print (6), p.1465-1471</ispartof><rights>2018 American Heart Association, Inc.</rights><rights>2015 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3923-c63ad2e83be4999bad949dac512878ccde9031bffe5095eb5cd5f53e92c0d41d3</citedby><cites>FETCH-LOGICAL-c3923-c63ad2e83be4999bad949dac512878ccde9031bffe5095eb5cd5f53e92c0d41d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26480930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bunch, T Jared</creatorcontrib><creatorcontrib>May, Heidi T</creatorcontrib><creatorcontrib>Bair, Tami L</creatorcontrib><creatorcontrib>Anderson, Jeffrey L</creatorcontrib><creatorcontrib>Crandall, Brian G</creatorcontrib><creatorcontrib>Cutler, Michael J</creatorcontrib><creatorcontrib>Jacobs, Victoria</creatorcontrib><creatorcontrib>Mallender, Charles</creatorcontrib><creatorcontrib>Muhlestein, Joseph B</creatorcontrib><creatorcontrib>Osborn, Jeffrey S</creatorcontrib><creatorcontrib>Weiss, J Peter</creatorcontrib><creatorcontrib>Day, John D</creatorcontrib><title>Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation</title><title>Circulation. Arrhythmia and electrophysiology</title><addtitle>Circ Arrhythm Electrophysiol</addtitle><description>BACKGROUND—There are a paucity of data regarding the long-term natural history of adult Wolff-Parkinson-White (WPW) syndrome patients in regard to risk of mortality and atrial fibrillation (AF). We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the natural history.
METHODS AND RESULTS—Three groups of patients were studied2 WPW populations (Ablation872, No Ablation1461) and a 1:5 control population (n=11,175). Long-term mortality and AF rates were determined. The average follow-up for the WPW group was 7.9 ± 5.9 (median6.9) years and was similar between the ablation and non-ablation groups. Death rates were similar between the WPW group versus the control group [HR=0.96 (95% CI0.83-1.11), p=0.56]. Non-ablated WPW patients had a higher long-term death risk compared to WPW ablation patients [HR=2.10 (95% CI1.50-20.93), p<0.0001). Incident AF risk was higher in the WPW group compared to the control population [HR=1.55 (95% CI1.29-1.87), p<0.0001]. Non-ablated WPW patients had lower risk than ablated patients [HR=0.39 (95% CI0.28-0.53), p<0.0001).
CONCLUSIONS—Long-term mortality rates in WPW patients are low and similar to an age- and gender-matched control population. AF rates are high long-term and ablation does not reduce this risk.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Catheter Ablation</subject><subject>Female</subject><subject>Humans</subject><subject>Idaho - epidemiology</subject><subject>Incidence</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Utah - epidemiology</subject><subject>Wolff-Parkinson-White Syndrome - diagnosis</subject><subject>Wolff-Parkinson-White Syndrome - mortality</subject><subject>Wolff-Parkinson-White Syndrome - physiopathology</subject><subject>Wolff-Parkinson-White Syndrome - surgery</subject><subject>Young Adult</subject><issn>1941-3149</issn><issn>1941-3084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQhS1UBJT2B_RS-diLwY7tEB9XERSkVVnRrThGjj1pUpyY2o5W--_rVZYemcu8w_eeZh5CXxi9Yqxk1_XDU327yVpeUcop4yfoginBCKeV-PCmmVDn6GOMfygtWcXKM3RelKKiitMLNK_99JtsIYz4h05z0A7fDzH5sMe-wys7u4Sfves6stHhZZiin8hzPyTAP_eTDX4EvNFpgClFvA2gE1i8G1KP9bQIPydc69RDgoBXrcuwnz6h0067CJ-P-xL9urvd1vdk_fj9oV6tieGq4MSUXNsCKt6CUEq12iqhrDaSFdVNZYwFRTlruw4kVRJaaazsJAdVGGoFs_wSfVtyX4P_O0NMzThEA87pCfwcG3ZzyC0YFRllC2qCjzFA17yGYdRh3zDaHNpulrazls3SdvZ8PcbP7Qj2v-Ot3gzIBdh5l_-PL27eQWh60C717waLd3wHIh_OiaLHIfmJivJ_H-CdYg</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Bunch, T Jared</creator><creator>May, Heidi T</creator><creator>Bair, Tami L</creator><creator>Anderson, Jeffrey L</creator><creator>Crandall, Brian G</creator><creator>Cutler, Michael J</creator><creator>Jacobs, Victoria</creator><creator>Mallender, Charles</creator><creator>Muhlestein, Joseph B</creator><creator>Osborn, Jeffrey S</creator><creator>Weiss, J Peter</creator><creator>Day, John D</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation</title><author>Bunch, T Jared ; May, Heidi T ; Bair, Tami L ; Anderson, Jeffrey L ; Crandall, Brian G ; Cutler, Michael J ; Jacobs, Victoria ; Mallender, Charles ; Muhlestein, Joseph B ; Osborn, Jeffrey S ; Weiss, J Peter ; Day, John D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3923-c63ad2e83be4999bad949dac512878ccde9031bffe5095eb5cd5f53e92c0d41d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Catheter Ablation</topic><topic>Female</topic><topic>Humans</topic><topic>Idaho - epidemiology</topic><topic>Incidence</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Utah - epidemiology</topic><topic>Wolff-Parkinson-White Syndrome - diagnosis</topic><topic>Wolff-Parkinson-White Syndrome - mortality</topic><topic>Wolff-Parkinson-White Syndrome - physiopathology</topic><topic>Wolff-Parkinson-White Syndrome - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bunch, T Jared</creatorcontrib><creatorcontrib>May, Heidi T</creatorcontrib><creatorcontrib>Bair, Tami L</creatorcontrib><creatorcontrib>Anderson, Jeffrey L</creatorcontrib><creatorcontrib>Crandall, Brian G</creatorcontrib><creatorcontrib>Cutler, Michael J</creatorcontrib><creatorcontrib>Jacobs, Victoria</creatorcontrib><creatorcontrib>Mallender, Charles</creatorcontrib><creatorcontrib>Muhlestein, Joseph B</creatorcontrib><creatorcontrib>Osborn, Jeffrey S</creatorcontrib><creatorcontrib>Weiss, J Peter</creatorcontrib><creatorcontrib>Day, John D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bunch, T Jared</au><au>May, Heidi T</au><au>Bair, Tami L</au><au>Anderson, Jeffrey L</au><au>Crandall, Brian G</au><au>Cutler, Michael J</au><au>Jacobs, Victoria</au><au>Mallender, Charles</au><au>Muhlestein, Joseph B</au><au>Osborn, Jeffrey S</au><au>Weiss, J Peter</au><au>Day, John D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation</atitle><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle><addtitle>Circ Arrhythm Electrophysiol</addtitle><date>2015-12</date><risdate>2015</risdate><volume>Publish Ahead of Print</volume><issue>6</issue><spage>1465</spage><epage>1471</epage><pages>1465-1471</pages><issn>1941-3149</issn><eissn>1941-3084</eissn><abstract>BACKGROUND—There are a paucity of data regarding the long-term natural history of adult Wolff-Parkinson-White (WPW) syndrome patients in regard to risk of mortality and atrial fibrillation (AF). We sought to describe the long-term outcomes of WPW patients and ascertain the impact of ablation on the natural history.
METHODS AND RESULTS—Three groups of patients were studied2 WPW populations (Ablation872, No Ablation1461) and a 1:5 control population (n=11,175). Long-term mortality and AF rates were determined. The average follow-up for the WPW group was 7.9 ± 5.9 (median6.9) years and was similar between the ablation and non-ablation groups. Death rates were similar between the WPW group versus the control group [HR=0.96 (95% CI0.83-1.11), p=0.56]. Non-ablated WPW patients had a higher long-term death risk compared to WPW ablation patients [HR=2.10 (95% CI1.50-20.93), p<0.0001). Incident AF risk was higher in the WPW group compared to the control population [HR=1.55 (95% CI1.29-1.87), p<0.0001]. Non-ablated WPW patients had lower risk than ablated patients [HR=0.39 (95% CI0.28-0.53), p<0.0001).
CONCLUSIONS—Long-term mortality rates in WPW patients are low and similar to an age- and gender-matched control population. AF rates are high long-term and ablation does not reduce this risk.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>26480930</pmid><doi>10.1161/CIRCEP.115.003013</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1941-3149 |
| ispartof | Circulation. Arrhythmia and electrophysiology, 2015-12, Vol.Publish Ahead of Print (6), p.1465-1471 |
| issn | 1941-3149 1941-3084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1749992104 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; American Heart Association |
| subjects | Adult Age Factors Aged Atrial Fibrillation - epidemiology Catheter Ablation Female Humans Idaho - epidemiology Incidence Kaplan-Meier Estimate Male Middle Aged Proportional Hazards Models Retrospective Studies Risk Factors Time Factors Treatment Outcome Utah - epidemiology Wolff-Parkinson-White Syndrome - diagnosis Wolff-Parkinson-White Syndrome - mortality Wolff-Parkinson-White Syndrome - physiopathology Wolff-Parkinson-White Syndrome - surgery Young Adult |
| title | Long-Term Natural History of Adult Wolff-Parkinson-White Syndrome Patients Treated with and without Catheter Ablation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T14%3A07%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-Term%20Natural%20History%20of%20Adult%20Wolff-Parkinson-White%20Syndrome%20Patients%20Treated%20with%20and%20without%20Catheter%20Ablation&rft.jtitle=Circulation.%20Arrhythmia%20and%20electrophysiology&rft.au=Bunch,%20T%20Jared&rft.date=2015-12&rft.volume=Publish%20Ahead%20of%20Print&rft.issue=6&rft.spage=1465&rft.epage=1471&rft.pages=1465-1471&rft.issn=1941-3149&rft.eissn=1941-3084&rft_id=info:doi/10.1161/CIRCEP.115.003013&rft_dat=%3Cproquest_cross%3E1749992104%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1749992104&rft_id=info:pmid/26480930&rfr_iscdi=true |