Mediators of Galactose Sensitivity in UDP-Galactose 4′-Epimerase-impaired Mammalian Cells

UDP-galactose 4′-epimerase (GALE) catalyzes the final step in the Leloir pathway of galactose metabolism, interconverting UDP-galactose and UDP-glucose. Unlike its Escherichia coli counterpart, mammalian GALE also interconverts UDP-N-acetylgalactosamine and UDP-N-acetylglucosamine. Considering the k...

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Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (14), p.13493-13502
Hauptverfasser:	Schulz, Jenny M., Ross, Kerry L., Malmstrom, Kerstin, Krieger, Monty, Fridovich-Keil, Judith L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromodeoxyuridine - metabolism CHO Cells Cricetinae Escherichia coli Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Galactose - metabolism Galactosemias - metabolism Humans Substrate Specificity UDPglucose 4-Epimerase - genetics UDPglucose 4-Epimerase - metabolism Uridine - metabolism Uridine Diphosphate Sugars - metabolism
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