Disposition of tiludronate (Skelid) in animals

1. The disposition of tiludronate in mouse, rat, rabbit, dog and monkey has been studied after oral and intravenous doses. Like other bisphosphonates, tiludronate was characterized by poor absorption from the gastrointestinal tract. Peak plasma concentrations appeared shortly (0.5-1 h) after dosing,...

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Veröffentlicht in:	Xenobiotica 1999-10, Vol.29 (10), p.1017-1031
Hauptverfasser:	Davi, H., Tronquet, C., Caix, J., Simiand, J., Briot, C., Berger, Y., Thiercelin, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological and medical sciences Blood Proteins - metabolism Bone and Bones - metabolism Bone Resorption - prevention & control Bones, joints and connective tissue. Antiinflammatory agents Diphosphonates - administration & dosage Diphosphonates - blood Diphosphonates - pharmacokinetics Dogs Female Food Haplorhini Intestinal Absorption Male Medical sciences Mice Papio Pharmacology. Drug treatments Protein Binding Rabbits Rats tiludronate Tissue Distribution
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