Mutagenicity and antimutagenicity studies of tannic acid and its related compounds
Tannic acid and its hydrolysed products such as ellagic acid, gallic acid and propyl gallate were tested for mutagenicities using Ames Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF),...
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| Veröffentlicht in: | Food and chemical toxicology 2000, Vol.38 (1), p.1-5 |
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| creator | Chen, Ssu-Ching Chung, King-Thom |
| description | Tannic acid and its hydrolysed products such as ellagic acid, gallic acid and propyl gallate were tested for mutagenicities using Ames
Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF), 4,4′-dinitro-2-biphenylamine, 1-nitropyrene, 1,3-dinitropyrene, 2-nitro-
p-phenylenediamine, 3-nitro-
o-phenylenediamine, 4-nitro-
o-phenylenediamine were tested. None of these tannic acid compounds was mutagenic. They also failed to show antimutagenic activity towards the tested direct mutagens. However, tannic acid at non-growth inhibitory concentrations reduced the revertant numbers of TA98 in the presence of S9 mix when benzidine, 3,3′-4,4′-tetraminobiphenyl, 4-aminobiphenyl, and
N,
N-
N′,
N′-tetramethylbenzidine were used as the mutagens. These results suggest that tannic acid, but not its hydrolytic products, affects the metabolic activation of these mutagens. |
| doi_str_mv | 10.1016/S0278-6915(99)00114-3 |
| format | Article |
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Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF), 4,4′-dinitro-2-biphenylamine, 1-nitropyrene, 1,3-dinitropyrene, 2-nitro-
p-phenylenediamine, 3-nitro-
o-phenylenediamine, 4-nitro-
o-phenylenediamine were tested. None of these tannic acid compounds was mutagenic. They also failed to show antimutagenic activity towards the tested direct mutagens. However, tannic acid at non-growth inhibitory concentrations reduced the revertant numbers of TA98 in the presence of S9 mix when benzidine, 3,3′-4,4′-tetraminobiphenyl, 4-aminobiphenyl, and
N,
N-
N′,
N′-tetramethylbenzidine were used as the mutagens. These results suggest that tannic acid, but not its hydrolytic products, affects the metabolic activation of these mutagens.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/S0278-6915(99)00114-3</identifier><identifier>PMID: 10685008</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>2-nitrofluorene ; Ames test ; antimutagenicity ; Biological and medical sciences ; Chemical mutagenesis ; Dose-Response Relationship, Drug ; ellagic acid ; Fixatives - pharmacology ; Fixatives - toxicity ; Food Additives - pharmacology ; Food Additives - toxicity ; Food toxicology ; gallic acid ; Hydrolyzable Tannins - analogs & derivatives ; Hydrolyzable Tannins - pharmacology ; Hydrolyzable Tannins - toxicity ; inhibition ; liver ; Medical sciences ; medicinal properties ; microsomes ; Mutagenesis - drug effects ; mutagenicity ; Mutagenicity Tests ; mutagens ; propyl gallate ; rats ; Salmonella - drug effects ; Salmonella - genetics ; Salmonella typhimurium ; tannic acid ; tannins ; testing ; Toxicology</subject><ispartof>Food and chemical toxicology, 2000, Vol.38 (1), p.1-5</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-9fb092935c7ec6f3c6fa388a977b66d56c76ff17f98011d4109aa1bea12aad373</citedby><cites>FETCH-LOGICAL-c511t-9fb092935c7ec6f3c6fa388a977b66d56c76ff17f98011d4109aa1bea12aad373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0278-6915(99)00114-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1306816$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10685008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ssu-Ching</creatorcontrib><creatorcontrib>Chung, King-Thom</creatorcontrib><title>Mutagenicity and antimutagenicity studies of tannic acid and its related compounds</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Tannic acid and its hydrolysed products such as ellagic acid, gallic acid and propyl gallate were tested for mutagenicities using Ames
Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF), 4,4′-dinitro-2-biphenylamine, 1-nitropyrene, 1,3-dinitropyrene, 2-nitro-
p-phenylenediamine, 3-nitro-
o-phenylenediamine, 4-nitro-
o-phenylenediamine were tested. None of these tannic acid compounds was mutagenic. They also failed to show antimutagenic activity towards the tested direct mutagens. However, tannic acid at non-growth inhibitory concentrations reduced the revertant numbers of TA98 in the presence of S9 mix when benzidine, 3,3′-4,4′-tetraminobiphenyl, 4-aminobiphenyl, and
N,
N-
N′,
N′-tetramethylbenzidine were used as the mutagens. These results suggest that tannic acid, but not its hydrolytic products, affects the metabolic activation of these mutagens.</description><subject>2-nitrofluorene</subject><subject>Ames test</subject><subject>antimutagenicity</subject><subject>Biological and medical sciences</subject><subject>Chemical mutagenesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>ellagic acid</subject><subject>Fixatives - pharmacology</subject><subject>Fixatives - toxicity</subject><subject>Food Additives - pharmacology</subject><subject>Food Additives - toxicity</subject><subject>Food toxicology</subject><subject>gallic acid</subject><subject>Hydrolyzable Tannins - analogs & derivatives</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>Hydrolyzable Tannins - toxicity</subject><subject>inhibition</subject><subject>liver</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>microsomes</subject><subject>Mutagenesis - drug effects</subject><subject>mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>mutagens</subject><subject>propyl gallate</subject><subject>rats</subject><subject>Salmonella - drug effects</subject><subject>Salmonella - genetics</subject><subject>Salmonella typhimurium</subject><subject>tannic acid</subject><subject>tannins</subject><subject>testing</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9rFTEQB_Agin2t_gnaPZRSD6uZzdtkcypS2ipUBGvPYV4yKSn745lkhf73pm8f2puHIZB8ZpJ8GXsH_CNwkJ9ueaO6Wmpoz7T-wDnAuhYv2Ao6JWopWnjJVn_JATtM6YFzrkDJ1-wAuOxazrsV-_FtznhPY7AhP1Y4ulI5DM83U55doFRNvso4ls0KbXA7G3KqIvWYyVV2GrbTPLr0hr3y2Cd6u1-P2N3V5c-LL_XN9-uvF59vatsC5Fr7DdeNFq1VZKUXpVB0HWqlNlK6VlolvQfldVc-59bANSJsCKFBdEKJI3a6zN3G6ddMKZshJEt9jyNNczKg1mWWhgLbBdo4pRTJm20MA8ZHA9w8hWl2YZqnpIzWZhemEaXv_f6CeTOQe9a1pFfAyR5gstj7iKMN6Z8TBYIs7HhhHieD97GQu9uGl-NGt7yEUcT5Iqjk9TtQNMkGGi25EMlm46bwn7f-AeFMmoY</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Chen, Ssu-Ching</creator><creator>Chung, King-Thom</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2000</creationdate><title>Mutagenicity and antimutagenicity studies of tannic acid and its related compounds</title><author>Chen, Ssu-Ching ; Chung, King-Thom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-9fb092935c7ec6f3c6fa388a977b66d56c76ff17f98011d4109aa1bea12aad373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>2-nitrofluorene</topic><topic>Ames test</topic><topic>antimutagenicity</topic><topic>Biological and medical sciences</topic><topic>Chemical mutagenesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>ellagic acid</topic><topic>Fixatives - pharmacology</topic><topic>Fixatives - toxicity</topic><topic>Food Additives - pharmacology</topic><topic>Food Additives - toxicity</topic><topic>Food toxicology</topic><topic>gallic acid</topic><topic>Hydrolyzable Tannins - analogs & derivatives</topic><topic>Hydrolyzable Tannins - pharmacology</topic><topic>Hydrolyzable Tannins - toxicity</topic><topic>inhibition</topic><topic>liver</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>microsomes</topic><topic>Mutagenesis - drug effects</topic><topic>mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>mutagens</topic><topic>propyl gallate</topic><topic>rats</topic><topic>Salmonella - drug effects</topic><topic>Salmonella - genetics</topic><topic>Salmonella typhimurium</topic><topic>tannic acid</topic><topic>tannins</topic><topic>testing</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ssu-Ching</creatorcontrib><creatorcontrib>Chung, King-Thom</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ssu-Ching</au><au>Chung, King-Thom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenicity and antimutagenicity studies of tannic acid and its related compounds</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2000</date><risdate>2000</risdate><volume>38</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Tannic acid and its hydrolysed products such as ellagic acid, gallic acid and propyl gallate were tested for mutagenicities using Ames
Salmonella tester strains TA98 and TA100. Also, the antimutagenic activities of these compounds against a number of direct mutagens including 2-nitrofluorene (2-NF), 4,4′-dinitro-2-biphenylamine, 1-nitropyrene, 1,3-dinitropyrene, 2-nitro-
p-phenylenediamine, 3-nitro-
o-phenylenediamine, 4-nitro-
o-phenylenediamine were tested. None of these tannic acid compounds was mutagenic. They also failed to show antimutagenic activity towards the tested direct mutagens. However, tannic acid at non-growth inhibitory concentrations reduced the revertant numbers of TA98 in the presence of S9 mix when benzidine, 3,3′-4,4′-tetraminobiphenyl, 4-aminobiphenyl, and
N,
N-
N′,
N′-tetramethylbenzidine were used as the mutagens. These results suggest that tannic acid, but not its hydrolytic products, affects the metabolic activation of these mutagens.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>10685008</pmid><doi>10.1016/S0278-6915(99)00114-3</doi><tpages>5</tpages></addata></record> |
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| subjects | 2-nitrofluorene Ames test antimutagenicity Biological and medical sciences Chemical mutagenesis Dose-Response Relationship, Drug ellagic acid Fixatives - pharmacology Fixatives - toxicity Food Additives - pharmacology Food Additives - toxicity Food toxicology gallic acid Hydrolyzable Tannins - analogs & derivatives Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - toxicity inhibition liver Medical sciences medicinal properties microsomes Mutagenesis - drug effects mutagenicity Mutagenicity Tests mutagens propyl gallate rats Salmonella - drug effects Salmonella - genetics Salmonella typhimurium tannic acid tannins testing Toxicology |
| title | Mutagenicity and antimutagenicity studies of tannic acid and its related compounds |
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