Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3 inflammasome activation

Morus bombycis Koidzumi (M. bombycis, Moraceae) has been used in Asian countries as a traditional medicine for the treatment of hypertension, diabetes, and inflammation-related disorders. Although its anti-inflammatory actions have been partly documented, scientific evidence involving its molecular...

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Veröffentlicht in:	Journal of ethnopharmacology 2015-12, Vol.176, p.424-428
Hauptverfasser:	Oh, Na-Hyun, Han, Ji-Won, Shim, Do-Wan, Sim, Eun-Jeong, Koppula, Sushruta, Kwak, Su-Bin, Kim, Myong-Ki, Kim, Young-Kyu, Jiang, Jun, Park, Pyo-Jam, Kang, Tae-Bong, Lee, Kwang-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammation Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cell Line Cells, Cultured Female Inflammasome Inflammasomes Interferon-beta - antagonists & inhibitors Interferon-beta - metabolism Interleukin-6 - metabolism Macrophages - drug effects Macrophages - metabolism Mice, Inbred C57BL Morus Morus bombycis Nitric Oxide - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Peritonitis Peritonitis - chemically induced Peritonitis - drug therapy Peritonitis - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Reactive Oxygen Species - metabolism TRIF Uric Acid
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