Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects
Metal oxide nanoparticles (MO-NPs) are the multidisciplinary nano-scaled molecules which are being used in the diagnosis and treatment of the challenging diseases including cancer. Evidence suggest that antimicrobial formulations in the form of MO-NPs can be possibly used as effective antimicrobial...
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| Veröffentlicht in: | Life sciences (1973) 2015-12, Vol.143, p.71-79 |
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| container_title | Life sciences (1973) |
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| creator | Tuli, Hardeep Singh Kashyap, Dharambir Bedi, Simranjeet Kaur Kumar, Pardeep Kumar, Gaurav Sandhu, Sardul Singh |
| description | Metal oxide nanoparticles (MO-NPs) are the multidisciplinary nano-scaled molecules which are being used in the diagnosis and treatment of the challenging diseases including cancer. Evidence suggest that antimicrobial formulations in the form of MO-NPs can be possibly used as effective antimicrobial agents. In addition, MO-NPs are known to target various cellular signaling pathways associated with apoptosis, angiogenesis, metastasis and inflammation of cancer. In combination with other chemotherapeutic/anticancer agents, MO-NPs not only increase their bioavailability and efficacy but also lower down the requirement of active dosages. To date, to our knowledge there is no single comprehensive report on cellular and molecular interactions of MO-NPs which have been well elaborated in this review. Also we highlight various action mechanisms through which MO-NPs act as antimicrobial, anticancer, antioxidant and anti-inflammatory agents.
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| doi_str_mv | 10.1016/j.lfs.2015.10.021 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2015-12, Vol.143, p.71-79 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-cancer Anti-inflammatory Anti-microbial Anti-oxidant Humans Metal Nanoparticles - therapeutic use Metal oxide Metals - metabolism Metals - therapeutic use Nanotechnology Neoplasms - drug therapy Neoplasms - metabolism Oxides - metabolism Oxides - therapeutic use Treatment Outcome |
| title | Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects |
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