Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis
Background and aims No endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from int...
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| Veröffentlicht in: | International journal of colorectal disease 2015-12, Vol.30 (12), p.1639-1643 |
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| creator | Moriichi, Kentaro Fujiya, Mikihiro Ijiri, Masami Tanaka, Kazuyuki Sakatani, Aki Dokoshi, Tatsuya Fujibayashi, Shugo Ando, Katsuyoshi Nomura, Yoshiki Ueno, Nobuhiro Kashima, Shin Gotoh, Takuma Sasajima, Junpei Inaba, Yuhei Ito, Takahiro Tanabe, Hiroki Saitoh, Yusuke Kohgo, Yutaka |
| description | Background and aims
No endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from intestinal tissue and then quantifies the intensity using an image-analytical software program.
Materials and methods
Eleven endoscopists separately evaluated 135 images of conventional endoscopy (CE) and AFI from a same lesion. A CE image corresponding to Mayo endoscopic subscore 0 or 1 was defined as being inactive. The fluorescence intensities of AFI were quantified using an image-analytical software program (F index; FI). Active inflammation was defined when Matts’ histological grade was 2 or more. A cut-off value of the FI for active inflammation was determined using a receiver operating characteristic (ROC) analysis. The inter-observer consistency was calculated by unweighted kappa statistics.
Results
The correlation coefficient for the FI was inversely related to the histological severity (
r
= −0.558,
p
|
| doi_str_mv | 10.1007/s00384-015-2332-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1749618525</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714489959</galeid><sourcerecordid>A714489959</sourcerecordid><originalsourceid>FETCH-LOGICAL-c575t-2ecf7bb9905e7acf5d750f61ad3d23a33d64927e3dfc9aab025e05718efb17e73</originalsourceid><addsrcrecordid>eNp1kVtrHSEUhaU0NKdpf0BfitCXvkzidRwfQ0gvECiB9lkcZ3vqYY6m6gTOv6_Tk15p8EG3fmuxtwuhV5ScU0LURSGED6IjVHaMc9bJJ2hDRTtQ1rOnaEOo0h3VcjhFz0vZkVb3SjxDp-25F0SoDSq3i401-OBsDSni5LFdavLzkjIUB9EBDnu7DXGLnY3YOrdkW2E-YBsnnMYduBruf9SlQCm4fgVc4B5yqIfVbpkdNEVjsEtzqKG8QCfezgVePuxn6Mu7689XH7qbT-8_Xl3edE4qWTsGzqtx1JpIUNZ5OSlJfE_txCfGLedTLzRTwCfvtLUjYRKIVHQAP1IFip-ht0ffu5y-LVCq2Yc20jzbCGkphiqhezpIJhv65h90l5YcW3crpSQfKO9_U1s7gwnRp5qtW03NpaJCDFpL3ajz_1BtTbAPLkXwod3_JaBHgcuplAze3OX25_lgKDFr0OYYtGlBmzVoszb8-qHhZdzD9EvxM9kGsCNQ2lPcQv5jokddvwNBjrQU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1747538136</pqid></control><display><type>article</type><title>Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Moriichi, Kentaro ; Fujiya, Mikihiro ; Ijiri, Masami ; Tanaka, Kazuyuki ; Sakatani, Aki ; Dokoshi, Tatsuya ; Fujibayashi, Shugo ; Ando, Katsuyoshi ; Nomura, Yoshiki ; Ueno, Nobuhiro ; Kashima, Shin ; Gotoh, Takuma ; Sasajima, Junpei ; Inaba, Yuhei ; Ito, Takahiro ; Tanabe, Hiroki ; Saitoh, Yusuke ; Kohgo, Yutaka</creator><creatorcontrib>Moriichi, Kentaro ; Fujiya, Mikihiro ; Ijiri, Masami ; Tanaka, Kazuyuki ; Sakatani, Aki ; Dokoshi, Tatsuya ; Fujibayashi, Shugo ; Ando, Katsuyoshi ; Nomura, Yoshiki ; Ueno, Nobuhiro ; Kashima, Shin ; Gotoh, Takuma ; Sasajima, Junpei ; Inaba, Yuhei ; Ito, Takahiro ; Tanabe, Hiroki ; Saitoh, Yusuke ; Kohgo, Yutaka</creatorcontrib><description>Background and aims
No endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from intestinal tissue and then quantifies the intensity using an image-analytical software program.
Materials and methods
Eleven endoscopists separately evaluated 135 images of conventional endoscopy (CE) and AFI from a same lesion. A CE image corresponding to Mayo endoscopic subscore 0 or 1 was defined as being inactive. The fluorescence intensities of AFI were quantified using an image-analytical software program (F index; FI). Active inflammation was defined when Matts’ histological grade was 2 or more. A cut-off value of the FI for active inflammation was determined using a receiver operating characteristic (ROC) analysis. The inter-observer consistency was calculated by unweighted kappa statistics.
Results
The correlation coefficient for the FI was inversely related to the histological severity (
r
= −0.558,
p
< 0.0001). The ROC analysis showed that the optimal cut-off value for the FI for active inflammation was 0.906. The average diagnostic accuracy of the FI was significantly higher than those of the CE (84.7 vs 78.5 %,
p
< 0.01). The kappa values for the inter-observer consistency of CE and the FI were 0.60 and 0.95 in all participants, 0.53 and 0.97 in the less-experienced endoscopists group and 0.67 and 0.93 in the expert group, respectively.
Conclusions
The quantified AFI is considered to be an accurate and objective indicator that can be used to assess the activity of ulcerative colitis, particularly for less-experienced endoscopists.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-015-2332-5</identifier><identifier>PMID: 26264047</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - pathology ; Endoscopy ; Endoscopy, Gastrointestinal ; Female ; Fluorescence ; Gastroenterology ; Hepatology ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Observer Variation ; Optical Imaging ; Original Article ; Proctology ; Prospective Studies ; Severity of Illness Index ; Surgery ; Ulcerative colitis</subject><ispartof>International journal of colorectal disease, 2015-12, Vol.30 (12), p.1639-1643</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-2ecf7bb9905e7acf5d750f61ad3d23a33d64927e3dfc9aab025e05718efb17e73</citedby><cites>FETCH-LOGICAL-c575t-2ecf7bb9905e7acf5d750f61ad3d23a33d64927e3dfc9aab025e05718efb17e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-015-2332-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-015-2332-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26264047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moriichi, Kentaro</creatorcontrib><creatorcontrib>Fujiya, Mikihiro</creatorcontrib><creatorcontrib>Ijiri, Masami</creatorcontrib><creatorcontrib>Tanaka, Kazuyuki</creatorcontrib><creatorcontrib>Sakatani, Aki</creatorcontrib><creatorcontrib>Dokoshi, Tatsuya</creatorcontrib><creatorcontrib>Fujibayashi, Shugo</creatorcontrib><creatorcontrib>Ando, Katsuyoshi</creatorcontrib><creatorcontrib>Nomura, Yoshiki</creatorcontrib><creatorcontrib>Ueno, Nobuhiro</creatorcontrib><creatorcontrib>Kashima, Shin</creatorcontrib><creatorcontrib>Gotoh, Takuma</creatorcontrib><creatorcontrib>Sasajima, Junpei</creatorcontrib><creatorcontrib>Inaba, Yuhei</creatorcontrib><creatorcontrib>Ito, Takahiro</creatorcontrib><creatorcontrib>Tanabe, Hiroki</creatorcontrib><creatorcontrib>Saitoh, Yusuke</creatorcontrib><creatorcontrib>Kohgo, Yutaka</creatorcontrib><title>Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Background and aims
No endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from intestinal tissue and then quantifies the intensity using an image-analytical software program.
Materials and methods
Eleven endoscopists separately evaluated 135 images of conventional endoscopy (CE) and AFI from a same lesion. A CE image corresponding to Mayo endoscopic subscore 0 or 1 was defined as being inactive. The fluorescence intensities of AFI were quantified using an image-analytical software program (F index; FI). Active inflammation was defined when Matts’ histological grade was 2 or more. A cut-off value of the FI for active inflammation was determined using a receiver operating characteristic (ROC) analysis. The inter-observer consistency was calculated by unweighted kappa statistics.
Results
The correlation coefficient for the FI was inversely related to the histological severity (
r
= −0.558,
p
< 0.0001). The ROC analysis showed that the optimal cut-off value for the FI for active inflammation was 0.906. The average diagnostic accuracy of the FI was significantly higher than those of the CE (84.7 vs 78.5 %,
p
< 0.01). The kappa values for the inter-observer consistency of CE and the FI were 0.60 and 0.95 in all participants, 0.53 and 0.97 in the less-experienced endoscopists group and 0.67 and 0.93 in the expert group, respectively.
Conclusions
The quantified AFI is considered to be an accurate and objective indicator that can be used to assess the activity of ulcerative colitis, particularly for less-experienced endoscopists.</description><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Endoscopy</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Optical Imaging</subject><subject>Original Article</subject><subject>Proctology</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><subject>Ulcerative colitis</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kVtrHSEUhaU0NKdpf0BfitCXvkzidRwfQ0gvECiB9lkcZ3vqYY6m6gTOv6_Tk15p8EG3fmuxtwuhV5ScU0LURSGED6IjVHaMc9bJJ2hDRTtQ1rOnaEOo0h3VcjhFz0vZkVb3SjxDp-25F0SoDSq3i401-OBsDSni5LFdavLzkjIUB9EBDnu7DXGLnY3YOrdkW2E-YBsnnMYduBruf9SlQCm4fgVc4B5yqIfVbpkdNEVjsEtzqKG8QCfezgVePuxn6Mu7689XH7qbT-8_Xl3edE4qWTsGzqtx1JpIUNZ5OSlJfE_txCfGLedTLzRTwCfvtLUjYRKIVHQAP1IFip-ht0ffu5y-LVCq2Yc20jzbCGkphiqhezpIJhv65h90l5YcW3crpSQfKO9_U1s7gwnRp5qtW03NpaJCDFpL3ajz_1BtTbAPLkXwod3_JaBHgcuplAze3OX25_lgKDFr0OYYtGlBmzVoszb8-qHhZdzD9EvxM9kGsCNQ2lPcQv5jokddvwNBjrQU</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Moriichi, Kentaro</creator><creator>Fujiya, Mikihiro</creator><creator>Ijiri, Masami</creator><creator>Tanaka, Kazuyuki</creator><creator>Sakatani, Aki</creator><creator>Dokoshi, Tatsuya</creator><creator>Fujibayashi, Shugo</creator><creator>Ando, Katsuyoshi</creator><creator>Nomura, Yoshiki</creator><creator>Ueno, Nobuhiro</creator><creator>Kashima, Shin</creator><creator>Gotoh, Takuma</creator><creator>Sasajima, Junpei</creator><creator>Inaba, Yuhei</creator><creator>Ito, Takahiro</creator><creator>Tanabe, Hiroki</creator><creator>Saitoh, Yusuke</creator><creator>Kohgo, Yutaka</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis</title><author>Moriichi, Kentaro ; Fujiya, Mikihiro ; Ijiri, Masami ; Tanaka, Kazuyuki ; Sakatani, Aki ; Dokoshi, Tatsuya ; Fujibayashi, Shugo ; Ando, Katsuyoshi ; Nomura, Yoshiki ; Ueno, Nobuhiro ; Kashima, Shin ; Gotoh, Takuma ; Sasajima, Junpei ; Inaba, Yuhei ; Ito, Takahiro ; Tanabe, Hiroki ; Saitoh, Yusuke ; Kohgo, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-2ecf7bb9905e7acf5d750f61ad3d23a33d64927e3dfc9aab025e05718efb17e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Colitis, Ulcerative - diagnosis</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Endoscopy</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Optical Imaging</topic><topic>Original Article</topic><topic>Proctology</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriichi, Kentaro</creatorcontrib><creatorcontrib>Fujiya, Mikihiro</creatorcontrib><creatorcontrib>Ijiri, Masami</creatorcontrib><creatorcontrib>Tanaka, Kazuyuki</creatorcontrib><creatorcontrib>Sakatani, Aki</creatorcontrib><creatorcontrib>Dokoshi, Tatsuya</creatorcontrib><creatorcontrib>Fujibayashi, Shugo</creatorcontrib><creatorcontrib>Ando, Katsuyoshi</creatorcontrib><creatorcontrib>Nomura, Yoshiki</creatorcontrib><creatorcontrib>Ueno, Nobuhiro</creatorcontrib><creatorcontrib>Kashima, Shin</creatorcontrib><creatorcontrib>Gotoh, Takuma</creatorcontrib><creatorcontrib>Sasajima, Junpei</creatorcontrib><creatorcontrib>Inaba, Yuhei</creatorcontrib><creatorcontrib>Ito, Takahiro</creatorcontrib><creatorcontrib>Tanabe, Hiroki</creatorcontrib><creatorcontrib>Saitoh, Yusuke</creatorcontrib><creatorcontrib>Kohgo, Yutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriichi, Kentaro</au><au>Fujiya, Mikihiro</au><au>Ijiri, Masami</au><au>Tanaka, Kazuyuki</au><au>Sakatani, Aki</au><au>Dokoshi, Tatsuya</au><au>Fujibayashi, Shugo</au><au>Ando, Katsuyoshi</au><au>Nomura, Yoshiki</au><au>Ueno, Nobuhiro</au><au>Kashima, Shin</au><au>Gotoh, Takuma</au><au>Sasajima, Junpei</au><au>Inaba, Yuhei</au><au>Ito, Takahiro</au><au>Tanabe, Hiroki</au><au>Saitoh, Yusuke</au><au>Kohgo, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>30</volume><issue>12</issue><spage>1639</spage><epage>1643</epage><pages>1639-1643</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Background and aims
No endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from intestinal tissue and then quantifies the intensity using an image-analytical software program.
Materials and methods
Eleven endoscopists separately evaluated 135 images of conventional endoscopy (CE) and AFI from a same lesion. A CE image corresponding to Mayo endoscopic subscore 0 or 1 was defined as being inactive. The fluorescence intensities of AFI were quantified using an image-analytical software program (F index; FI). Active inflammation was defined when Matts’ histological grade was 2 or more. A cut-off value of the FI for active inflammation was determined using a receiver operating characteristic (ROC) analysis. The inter-observer consistency was calculated by unweighted kappa statistics.
Results
The correlation coefficient for the FI was inversely related to the histological severity (
r
= −0.558,
p
< 0.0001). The ROC analysis showed that the optimal cut-off value for the FI for active inflammation was 0.906. The average diagnostic accuracy of the FI was significantly higher than those of the CE (84.7 vs 78.5 %,
p
< 0.01). The kappa values for the inter-observer consistency of CE and the FI were 0.60 and 0.95 in all participants, 0.53 and 0.97 in the less-experienced endoscopists group and 0.67 and 0.93 in the expert group, respectively.
Conclusions
The quantified AFI is considered to be an accurate and objective indicator that can be used to assess the activity of ulcerative colitis, particularly for less-experienced endoscopists.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26264047</pmid><doi>10.1007/s00384-015-2332-5</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2015-12, Vol.30 (12), p.1639-1643 |
| issn | 0179-1958 1432-1262 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1749618525 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Colitis, Ulcerative - diagnosis Colitis, Ulcerative - pathology Endoscopy Endoscopy, Gastrointestinal Female Fluorescence Gastroenterology Hepatology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Observer Variation Optical Imaging Original Article Proctology Prospective Studies Severity of Illness Index Surgery Ulcerative colitis |
| title | Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis |
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