Leprosy is teaching us the immunopathogenesis of inflammatory skin disease
The TH22 subset has been discovered in leprosy, with increased IL-22 in TH2 anergic lepromatous leprosy and decreased IL-22 in TH1 tuberculoid leprosy with intact cell-mediated immunity.2 The increase in IL-22 at the TH2 lepromatous pole corresponds to the increase in IL-22 in TH2 atopic dermatitis...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2015-12, Vol.136 (6), p.1707-1707 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Rendini, Tina, RN Levis, William, MD |
| description | The TH22 subset has been discovered in leprosy, with increased IL-22 in TH2 anergic lepromatous leprosy and decreased IL-22 in TH1 tuberculoid leprosy with intact cell-mediated immunity.2 The increase in IL-22 at the TH2 lepromatous pole corresponds to the increase in IL-22 in TH2 atopic dermatitis versus TH1 psoriasis.1 TH22 is well established in both TH1 psoriasis and TH2 atopic dermatitis.3 Leprosy is the first disease classified by the T cell, with TH1 paucibacillary tuberculoid disease with intact cell-mediated immunity and TH2 multibacillary lepromatous disease anergic to Mycobacterium leprae epitopes.4 TH22 cells like TH17 cells are less stable phenotypes compared with the polar TH1 and TH2 subsets. |
| doi_str_mv | 10.1016/j.jaci.2015.08.029 |
| format | Article |
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CD8-Positive T-Lymphocytes - immunology ; Dermatitis ; Dermatitis, Atopic - immunology ; Female ; Humans ; Leprosy ; Male ; Psoriasis ; Skin - immunology ; Skin diseases ; T-Lymphocyte Subsets - immunology ; Th17 Cells - immunology ; Th2 Cells - immunology</subject><ispartof>Journal of allergy and clinical immunology, 2015-12, Vol.136 (6), p.1707-1707</ispartof><rights>2015</rights><rights>Copyright Elsevier Limited Dec 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-4725e4cc3096903e7dbef42daa942f24fa92ca5b8d92dde627d1e3b8222834a43</citedby><cites>FETCH-LOGICAL-c553t-4725e4cc3096903e7dbef42daa942f24fa92ca5b8d92dde627d1e3b8222834a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2015.08.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26456037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rendini, Tina, RN</creatorcontrib><creatorcontrib>Levis, William, MD</creatorcontrib><title>Leprosy is teaching us the immunopathogenesis of inflammatory skin disease</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>The TH22 subset has been discovered in leprosy, with increased IL-22 in TH2 anergic lepromatous leprosy and decreased IL-22 in TH1 tuberculoid leprosy with intact cell-mediated immunity.2 The increase in IL-22 at the TH2 lepromatous pole corresponds to the increase in IL-22 in TH2 atopic dermatitis versus TH1 psoriasis.1 TH22 is well established in both TH1 psoriasis and TH2 atopic dermatitis.3 Leprosy is the first disease classified by the T cell, with TH1 paucibacillary tuberculoid disease with intact cell-mediated immunity and TH2 multibacillary lepromatous disease anergic to Mycobacterium leprae epitopes.4 TH22 cells like TH17 cells are less stable phenotypes compared with the polar TH1 and TH2 subsets.</description><subject>Allergy and Immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Leprosy</subject><subject>Male</subject><subject>Psoriasis</subject><subject>Skin - immunology</subject><subject>Skin diseases</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi1ERZfCH-CAInHhkmCPPxJLCAlVUEAr9dBytrz2pOs0cZY4Qdp_j6MtReqBk8fSM69mniHkDaMVo0x96KrOulABZbKiTUVBPyMbRnVdqgbkc7KhVLNS1UKfk5cpdTT_eaNfkHNQQirK6w35scXDNKZjEVIxo3X7EO-KJdd7LMIwLHE82Hk_3mHElJGxLUJsezsMdh6nY5HuQyx8SGgTviJnre0Tvn54L8jPr19uL7-V2-ur75eft6WTks-lqEGicI5TrTTlWPsdtgK8tVpAC6K1GpyVu8Zr8B4V1J4h3zUA0HBhBb8g70-5efBfC6bZDCE57HsbcVySYXlhxRrKWEbfPUG7cZlinm6llNRCcp0pOFEum0gTtuYwhcFOR8OoWU2bzqymzWra0MZk07np7UP0shvQP7b8VZuBjycAs4vfASeTXMDo0IcJ3Wz8GP6f_-lJu-tDDM7293jE9G8Pk8BQc7Peej01k5SB5Iz_AWdTo6A</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Rendini, Tina, RN</creator><creator>Levis, William, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Leprosy is teaching us the immunopathogenesis of inflammatory skin disease</title><author>Rendini, Tina, RN ; 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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Allergy and Immunology CD8-Positive T-Lymphocytes - immunology Dermatitis Dermatitis, Atopic - immunology Female Humans Leprosy Male Psoriasis Skin - immunology Skin diseases T-Lymphocyte Subsets - immunology Th17 Cells - immunology Th2 Cells - immunology |
| title | Leprosy is teaching us the immunopathogenesis of inflammatory skin disease |
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