Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms
This timely review starts by reporting the clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae. This growth pattern is so rare that it was not included in 2014 WHO classification of pulmonary neuroendocrine neoplasms. The...
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| Veröffentlicht in: | Diagnostic cytopathology 2016-01, Vol.44 (1), p.52-60 |
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| creator | Yang, Grace C. H. |
| description | This timely review starts by reporting the clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae. This growth pattern is so rare that it was not included in 2014 WHO classification of pulmonary neuroendocrine neoplasms. The current concept is reviewed, and example of spindle cell carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma are illustrated with fine needle aspiration cytology, surgical and clinical follow‐up. Finally, the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed and summarized in a tumorigenic module. Diagn. Cytopathol. 2016;44:52–60. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/dc.23376 |
| format | Article |
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H.</creatorcontrib><title>Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>This timely review starts by reporting the clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae. This growth pattern is so rare that it was not included in 2014 WHO classification of pulmonary neuroendocrine neoplasms. The current concept is reviewed, and example of spindle cell carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma are illustrated with fine needle aspiration cytology, surgical and clinical follow‐up. Finally, the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed and summarized in a tumorigenic module. Diagn. Cytopathol. 2016;44:52–60. © 2015 Wiley Periodicals, Inc.</description><subject>atypical carcinoid</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biopsy, Needle</subject><subject>Carcinoid Tumor - diagnosis</subject><subject>Carcinoid Tumor - genetics</subject><subject>Carcinoid Tumor - pathology</subject><subject>Carcinoma, Large Cell - diagnosis</subject><subject>Carcinoma, Large Cell - genetics</subject><subject>Carcinoma, Large Cell - pathology</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Small Cell - diagnosis</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Cytodiagnosis - methods</subject><subject>Diagnosis, Differential</subject><subject>fine needle aspiration cytology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Ki-67 Antigen - genetics</subject><subject>large cell neuroendocrine carcinoma</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>papillary carcinoid</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>small cell lung carcinoma</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Proteins - genetics</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10V1rFDEUBuAgFrtWwV8gA954M21OvudSVq1iqRd-9DJkksyaOpOMyQ66_95su60g9CoEnryc8wahF4BPAWNy5uwpoVSKR2gFuJMtprR7jFZKct4Cpt0xelrKNca4IyCeoGMiGJcKkxXS6902_Qhlm8a02TVpaGYzh3E0eddYk22IKbjGRNf4yedNiJvGpmj9vL2xyziluLfRLzn56JLNIfp6TfNoylSeoaPBjMU_P5wn6Nv7d1_XH9qLz-cf128uWstAibYDkN4aznsG0FtGlJSUAx-cUkawXnAHQycZeGWJqm-YU5JKPvRgeicZPUGvb3PnnH4tvmz1FIr1dZE6ylI0SNYJEISpSl_9R6_TkmOdbq8Up5KA-hdocyol-0HPOUx1VQ1Y70vXzuqb0it9eQhc-sm7e3jXcgXtLfgdRr97MEi_Xd8FHnz9F__n3pv8U4v91vrq8lzjq09fgJPvGtO_S-iZRQ</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Yang, Grace C. 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H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4186-9117eca55b411bc428773515fd88a64b65d1f9741e8c28c414d87375fb1abd743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>atypical carcinoid</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biopsy, Needle</topic><topic>Carcinoid Tumor - diagnosis</topic><topic>Carcinoid Tumor - genetics</topic><topic>Carcinoid Tumor - pathology</topic><topic>Carcinoma, Large Cell - diagnosis</topic><topic>Carcinoma, Large Cell - genetics</topic><topic>Carcinoma, Large Cell - pathology</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Small Cell - diagnosis</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Cytodiagnosis - methods</topic><topic>Diagnosis, Differential</topic><topic>fine needle aspiration cytology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Ki-67 Antigen - genetics</topic><topic>large cell neuroendocrine carcinoma</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>papillary carcinoid</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>small cell lung carcinoma</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Grace C. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Grace C. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>44</volume><issue>1</issue><spage>52</spage><epage>60</epage><pages>52-60</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>This timely review starts by reporting the clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae. This growth pattern is so rare that it was not included in 2014 WHO classification of pulmonary neuroendocrine neoplasms. The current concept is reviewed, and example of spindle cell carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma are illustrated with fine needle aspiration cytology, surgical and clinical follow‐up. Finally, the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed and summarized in a tumorigenic module. Diagn. Cytopathol. 2016;44:52–60. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26457802</pmid><doi>10.1002/dc.23376</doi><tpages>9</tpages></addata></record> |
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| subjects | atypical carcinoid Biomarkers, Tumor - genetics Biopsy, Needle Carcinoid Tumor - diagnosis Carcinoid Tumor - genetics Carcinoid Tumor - pathology Carcinoma, Large Cell - diagnosis Carcinoma, Large Cell - genetics Carcinoma, Large Cell - pathology Carcinoma, Papillary - diagnosis Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - genetics Carcinoma, Small Cell - pathology Cytodiagnosis - methods Diagnosis, Differential fine needle aspiration cytology Gene Expression Humans Ki-67 Antigen - genetics large cell neuroendocrine carcinoma Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - pathology papillary carcinoid Proto-Oncogene Proteins - genetics small cell lung carcinoma Tumor Suppressor Protein p53 - genetics Tumor Suppressor Proteins - genetics |
| title | Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms |
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