Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes

Photochemotherapy using 8-methoxypsoralen in combination with UVA radiation (PUVA) is an effective treatment for various skin dermatosis including psoriasis however its molecular mechanism is not clear. Previously we demonstrated that PUVA differentially regulates miRNA expression profile with a sig...

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Veröffentlicht in:	Cellular signalling 2016-01, Vol.28 (1), p.25-33
Hauptverfasser:	Chowdhari, Shruti, Saini, Neeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Gene Expression Profiling Humans Interferon Regulatory Factor-3 - metabolism Keratinocytes - metabolism Methoxsalen - pharmacology MicroRNAs - genetics miR-4516/UBE2N axis p53 Psoriasis PUVA PUVA Therapy - methods Receptors, Immunologic RIG-1 like receptor signaling Skin - drug effects Skin Neoplasms - metabolism Tumor Suppressor Protein p53 - metabolism Up-Regulation
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