ANTIPROLIFERATIVE AND CYTOTOXIC EFFECT OF SELECTED VITAMIN D ANALOGS ON NASAL POLYPS FIBROBLASTS AND OTHER CELLS WITH HIGHER PROLIFERATIVE POTENTIAL

Besides well-known effect on bone and mineral metabolism vitamin D is involved in essential non-calcemic regulatory mechanisms, such as cellular proliferation, differentiation and apoptosis in various cell types. Major limitation for therapeutic use of calcitriol, a hormonally active form of vitamin...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2015-09, Vol.72 (5), p.923-929
Hauptverfasser:	Frączek, Marcin, Kuśmierz, Dariusz, Rostkowska-Nadolska, Beata, Kutner, Andrzej, Latocha, Małgorzata T
Format:	Artikel
Sprache:	eng
Schlagworte:	bcl-2-Associated X Protein - genetics Calcitriol - pharmacology Cell Proliferation - drug effects Cells, Cultured Fibroblasts - drug effects Genes, bcl-2 Humans Nasal Polyps - drug therapy Nasal Polyps - pathology Vitamin D - analogs & derivatives Vitamin D - pharmacology
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