SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES
THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and n...
Gespeichert in:
| Veröffentlicht in: | Acta Poloniae pharmaceutica 2015-09, Vol.72 (5), p.851-866 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 866 |
|---|---|
| container_issue | 5 |
| container_start_page | 851 |
| container_title | Acta Poloniae pharmaceutica |
| container_volume | 72 |
| creator | Nowak, Kacper Pliński, Edward F Karolewicz, Bożena Jarząb, Przemysław P Plińska, Stanisława Fuglewicz, Bogusław Walczakowski, Michał J Augustyn, Łukasz Sterczewsk, Łukasz A Grzelczak, Michał P Hruszowiec, Mariusz Beziuk, Grzegorz Mikulic, Martin Pałka, Norbert Szustakowskip, Mieczysław |
| description | THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1749614057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1749614057</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-5079c6b03a22734bfbd1672880054c382f11f6028abb1d9c9d86f5ae60b331fe3</originalsourceid><addsrcrecordid>eNo1jzFvgzAUhD20aqI0f6Hy2AXJzwbbjMh1ChINCMjQLgiDkVJBQyEM_fclTTrdvdOn07s7tCaEgMMlEyu0nabP5SSeK3yAB7SinHOP-bBGOtexVoV-wUGeLibHyQ4XOgtCnRUf-C_Lklwl6TuO9jgNg-wtUPpQRCqIca4ivVc6f0T3bdVNdnvTDTrsdKFCJ05eL6AzUICz4xHh19wQVlEqmGta0wAXVMrLazWTtAVoOaGyMgYav_YbyVuvspwYxqC1bIOer73DePqe7XQu--NU266rvuxpnkoQrs_BJZ5Y0KcbOpveNuUwHvtq_Cn_p7Nf1RNNMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749614057</pqid></control><display><type>article</type><title>SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Nowak, Kacper ; Pliński, Edward F ; Karolewicz, Bożena ; Jarząb, Przemysław P ; Plińska, Stanisława ; Fuglewicz, Bogusław ; Walczakowski, Michał J ; Augustyn, Łukasz ; Sterczewsk, Łukasz A ; Grzelczak, Michał P ; Hruszowiec, Mariusz ; Beziuk, Grzegorz ; Mikulic, Martin ; Pałka, Norbert ; Szustakowskip, Mieczysław</creator><creatorcontrib>Nowak, Kacper ; Pliński, Edward F ; Karolewicz, Bożena ; Jarząb, Przemysław P ; Plińska, Stanisława ; Fuglewicz, Bogusław ; Walczakowski, Michał J ; Augustyn, Łukasz ; Sterczewsk, Łukasz A ; Grzelczak, Michał P ; Hruszowiec, Mariusz ; Beziuk, Grzegorz ; Mikulic, Martin ; Pałka, Norbert ; Szustakowskip, Mieczysław</creatorcontrib><description>THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings.</description><identifier>ISSN: 0001-6837</identifier><identifier>PMID: 26665391</identifier><language>eng</language><publisher>Poland</publisher><subject>Excipients - analysis ; Pharmaceutical Preparations - analysis ; Tablets ; Terahertz Spectroscopy - methods</subject><ispartof>Acta Poloniae pharmaceutica, 2015-09, Vol.72 (5), p.851-866</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26665391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nowak, Kacper</creatorcontrib><creatorcontrib>Pliński, Edward F</creatorcontrib><creatorcontrib>Karolewicz, Bożena</creatorcontrib><creatorcontrib>Jarząb, Przemysław P</creatorcontrib><creatorcontrib>Plińska, Stanisława</creatorcontrib><creatorcontrib>Fuglewicz, Bogusław</creatorcontrib><creatorcontrib>Walczakowski, Michał J</creatorcontrib><creatorcontrib>Augustyn, Łukasz</creatorcontrib><creatorcontrib>Sterczewsk, Łukasz A</creatorcontrib><creatorcontrib>Grzelczak, Michał P</creatorcontrib><creatorcontrib>Hruszowiec, Mariusz</creatorcontrib><creatorcontrib>Beziuk, Grzegorz</creatorcontrib><creatorcontrib>Mikulic, Martin</creatorcontrib><creatorcontrib>Pałka, Norbert</creatorcontrib><creatorcontrib>Szustakowskip, Mieczysław</creatorcontrib><title>SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES</title><title>Acta Poloniae pharmaceutica</title><addtitle>Acta Pol Pharm</addtitle><description>THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings.</description><subject>Excipients - analysis</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Tablets</subject><subject>Terahertz Spectroscopy - methods</subject><issn>0001-6837</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jzFvgzAUhD20aqI0f6Hy2AXJzwbbjMh1ChINCMjQLgiDkVJBQyEM_fclTTrdvdOn07s7tCaEgMMlEyu0nabP5SSeK3yAB7SinHOP-bBGOtexVoV-wUGeLibHyQ4XOgtCnRUf-C_Lklwl6TuO9jgNg-wtUPpQRCqIca4ivVc6f0T3bdVNdnvTDTrsdKFCJ05eL6AzUICz4xHh19wQVlEqmGta0wAXVMrLazWTtAVoOaGyMgYav_YbyVuvspwYxqC1bIOer73DePqe7XQu--NU266rvuxpnkoQrs_BJZ5Y0KcbOpveNuUwHvtq_Cn_p7Nf1RNNMw</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Nowak, Kacper</creator><creator>Pliński, Edward F</creator><creator>Karolewicz, Bożena</creator><creator>Jarząb, Przemysław P</creator><creator>Plińska, Stanisława</creator><creator>Fuglewicz, Bogusław</creator><creator>Walczakowski, Michał J</creator><creator>Augustyn, Łukasz</creator><creator>Sterczewsk, Łukasz A</creator><creator>Grzelczak, Michał P</creator><creator>Hruszowiec, Mariusz</creator><creator>Beziuk, Grzegorz</creator><creator>Mikulic, Martin</creator><creator>Pałka, Norbert</creator><creator>Szustakowskip, Mieczysław</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES</title><author>Nowak, Kacper ; Pliński, Edward F ; Karolewicz, Bożena ; Jarząb, Przemysław P ; Plińska, Stanisława ; Fuglewicz, Bogusław ; Walczakowski, Michał J ; Augustyn, Łukasz ; Sterczewsk, Łukasz A ; Grzelczak, Michał P ; Hruszowiec, Mariusz ; Beziuk, Grzegorz ; Mikulic, Martin ; Pałka, Norbert ; Szustakowskip, Mieczysław</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-5079c6b03a22734bfbd1672880054c382f11f6028abb1d9c9d86f5ae60b331fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Excipients - analysis</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Tablets</topic><topic>Terahertz Spectroscopy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nowak, Kacper</creatorcontrib><creatorcontrib>Pliński, Edward F</creatorcontrib><creatorcontrib>Karolewicz, Bożena</creatorcontrib><creatorcontrib>Jarząb, Przemysław P</creatorcontrib><creatorcontrib>Plińska, Stanisława</creatorcontrib><creatorcontrib>Fuglewicz, Bogusław</creatorcontrib><creatorcontrib>Walczakowski, Michał J</creatorcontrib><creatorcontrib>Augustyn, Łukasz</creatorcontrib><creatorcontrib>Sterczewsk, Łukasz A</creatorcontrib><creatorcontrib>Grzelczak, Michał P</creatorcontrib><creatorcontrib>Hruszowiec, Mariusz</creatorcontrib><creatorcontrib>Beziuk, Grzegorz</creatorcontrib><creatorcontrib>Mikulic, Martin</creatorcontrib><creatorcontrib>Pałka, Norbert</creatorcontrib><creatorcontrib>Szustakowskip, Mieczysław</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Poloniae pharmaceutica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nowak, Kacper</au><au>Pliński, Edward F</au><au>Karolewicz, Bożena</au><au>Jarząb, Przemysław P</au><au>Plińska, Stanisława</au><au>Fuglewicz, Bogusław</au><au>Walczakowski, Michał J</au><au>Augustyn, Łukasz</au><au>Sterczewsk, Łukasz A</au><au>Grzelczak, Michał P</au><au>Hruszowiec, Mariusz</au><au>Beziuk, Grzegorz</au><au>Mikulic, Martin</au><au>Pałka, Norbert</au><au>Szustakowskip, Mieczysław</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES</atitle><jtitle>Acta Poloniae pharmaceutica</jtitle><addtitle>Acta Pol Pharm</addtitle><date>2015-09</date><risdate>2015</risdate><volume>72</volume><issue>5</issue><spage>851</spage><epage>866</epage><pages>851-866</pages><issn>0001-6837</issn><abstract>THz-TDS techniques are applied to investigate selected pharmaceutical samples. Investigations were performed on selected pharmaceutical samples with active pharmaceutical ingredients (API)--famotidine, ranitidine, fenofibrate, lovastatin, simvastatin, aspirin, ketoconazole, acyclovir (hydrated and non-hydrated), on excipients--lactose, glucose (hydrated and non-hydrated), Pluronic 127, and on mixtures of selected compounds. Pseudo-polymorphism effects are considered as well. Examples of the terahertz imaging technique are also given. APIs and excipients can be easily recognized in the terahertz band by their specific "fingerprints" as individual components and in mixtures. The hydration process as a variety of polymorphism can also be easily monitored using the THz technique. Moreover, terahertz light can be useful for the penetration of tablets, giving clear pictures of possible defects in tablet coatings.</abstract><cop>Poland</cop><pmid>26665391</pmid><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6837 |
| ispartof | Acta Poloniae pharmaceutica, 2015-09, Vol.72 (5), p.851-866 |
| issn | 0001-6837 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1749614057 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Excipients - analysis Pharmaceutical Preparations - analysis Tablets Terahertz Spectroscopy - methods |
| title | SELECTED ASPECTS OF TERAHERTZ SPECTROSCOPY IN PHARMACEUTICAL SCIENCES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T13%3A32%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SELECTED%20ASPECTS%20OF%20TERAHERTZ%20SPECTROSCOPY%20IN%20PHARMACEUTICAL%20SCIENCES&rft.jtitle=Acta%20Poloniae%20pharmaceutica&rft.au=Nowak,%20Kacper&rft.date=2015-09&rft.volume=72&rft.issue=5&rft.spage=851&rft.epage=866&rft.pages=851-866&rft.issn=0001-6837&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1749614057%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1749614057&rft_id=info:pmid/26665391&rfr_iscdi=true |