Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites

Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes. Although its intrinsic ligand remains unknown, ZAG binds the dansylated C11 fatty acid 11-(dansylamino)undecanoic acid (DAUDA) in the groove between the α1 and α2 domains. The surf...

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Veröffentlicht in:	Biochemical journal 2016-01, Vol.473 (1), p.43-54
Hauptverfasser:	Zahid, Henna, Miah, Layeque, Lau, Andy M, Brochard, Lea, Hati, Debolina, Bui, Tam T T, Drake, Alex F, Gor, Jayesh, Perkins, Stephen J, McDermott, Lindsay C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines Binding Sites - physiology Carrier Proteins - chemistry Carrier Proteins - metabolism Fatty Acids - chemistry Fatty Acids - metabolism Glycoproteins - chemistry Glycoproteins - metabolism Humans Protein Structure, Secondary Protein Structure, Tertiary Zinc - metabolism Zinc - pharmacology
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