Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice
Highlights • Prevention of epilepsy in patients at risk is a major unmet clinical need. • Epilepsy is a network phenomenon, so that a single drug can probably not halt epileptogenesis. • Combinations of multitargeted drugs may be more effective, but have not been tested as yet. • An algorithm for te...
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| Veröffentlicht in: | Epilepsy research 2015-12, Vol.118, p.34-48 |
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| container_title | Epilepsy research |
| container_volume | 118 |
| creator | Klee, Rebecca Töllner, Kathrin Rankovic, Vladan Römermann, Kerstin Schidlitzki, Alina Bankstahl, Marion Löscher, Wolfgang |
| description | Highlights • Prevention of epilepsy in patients at risk is a major unmet clinical need. • Epilepsy is a network phenomenon, so that a single drug can probably not halt epileptogenesis. • Combinations of multitargeted drugs may be more effective, but have not been tested as yet. • An algorithm for testing drug combinations in naive and post-status epilepticus rodents is presented. • As a first step, tolerability of rationally chosen drug combinations was evaluated in mice. |
| doi_str_mv | 10.1016/j.eplepsyres.2015.11.003 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0920-1211 |
| ispartof | Epilepsy research, 2015-12, Vol.118, p.34-48 |
| issn | 0920-1211 1872-6844 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anticonvulsants - therapeutic use Antiepileptic drugs Blood–brain barrier Disease Models, Animal Drug adverse effects Drug Therapy, Combination - methods Epilepsy Excitatory Amino Acid Agonists - toxicity Female Inflammation Kainic Acid - toxicity Male Mice Muscarinic Agonists - toxicity Neurology Pilocarpine - toxicity Sex Factors Status Epilepticus - chemically induced Status Epilepticus - drug therapy Time Factors |
| title | Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice |
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