FGF signalling regulates bone growth through autophagy

During postnatal development in mice, the growth factor FGF18 induces autophagy in the chondrocyte cells of the growth plate to regulate the secretion of type II collagen, a process required for bone growth. Skeletal growth regulated by autophagy It is well established that biosynthetic processes af...

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Veröffentlicht in:	Nature (London) 2015-12, Vol.528 (7581), p.272-275
Hauptverfasser:	Cinque, Laura, Forrester, Alison, Bartolomeo, Rosa, Svelto, Maria, Venditti, Rossella, Montefusco, Sandro, Polishchuk, Elena, Nusco, Edoardo, Rossi, Antonio, Medina, Diego L., Polishchuk, Roman, De Matteis, Maria Antonietta, Settembre, Carmine
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/818 631/80/39 Animals Autophagy Autophagy (Cytology) Autophagy - genetics Autophagy - physiology Autophagy-Related Protein 7 Bone Development - genetics Bone Development - physiology Bones Cell Differentiation Cell Proliferation Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Collagen Type II - metabolism Embryo, Mammalian Extracellular Matrix - genetics Fibroblast growth factors Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Growth Growth factors Growth Plate - cytology Growth Plate - metabolism Humanities and Social Sciences letter MAP Kinase Signaling System Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism multidisciplinary Physiological aspects Receptor, Fibroblast Growth Factor, Type 4 - genetics Receptor, Fibroblast Growth Factor, Type 4 - metabolism Science Signal Transduction
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