Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets

Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling. Conversely, mild but enhanced integri...

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Veröffentlicht in:	Experimental cell research 2015-12, Vol.339 (2), p.261-269
Hauptverfasser:	Uchtmann, Kristen, Park, Electa R., Bergsma, Alexis, Segula, Justin, Edick, Mathew J., Miranti, Cindy K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood platelets Blood Platelets - metabolism Cell adhesion Clot Retraction - genetics Disease model-animals Humans Integrins Kangai-1 Protein - deficiency Kangai-1 Protein - genetics Mice Mice, Knockout Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Tetraspanins
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