Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MAS...

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Veröffentlicht in:	The American journal of surgical pathology 2016-01, Vol.40 (1), p.3-13
Hauptverfasser:	Skálová, Alena, Vanecek, Tomas, Simpson, Roderick H.W, Laco, Jan, Majewska, Hanna, Baneckova, Martina, Steiner, Petr, Michal, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biomarkers, Tumor - genetics ETS Translocation Variant 6 Protein Female Gene Fusion Gene Rearrangement Genetic Predisposition to Disease Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Mammary Analogue Secretory Carcinoma - chemistry Mammary Analogue Secretory Carcinoma - genetics Mammary Analogue Secretory Carcinoma - pathology Mammary Analogue Secretory Carcinoma - therapy Middle Aged Molecular Diagnostic Techniques Oncogene Proteins, Fusion - genetics Predictive Value of Tests Prognosis Proto-Oncogene Proteins c-ets - genetics Registries Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Salivary Gland Neoplasms - chemistry Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - pathology Salivary Gland Neoplasms - therapy Young Adult
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