Lysophosphatidic Acid Inhibits Adipocyte Differentiation via Lysophosphatidic Acid 1 Receptor-dependent Down-regulation of Peroxisome Proliferator-activated Receptor gamma 2

Lysophosphatidic acid (LPA) is a bioactive phospholipid acting via specific G protein-coupled receptors that is synthesized at the extracellular face of adipocytes by a secreted lysophospholipase D (autotaxin). Preadipocytes mainly express the LPA sub(1) receptor subtype, and LPA increases their pro...

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Veröffentlicht in:The Journal of biological chemistry 2005-04, Vol.280 (15), p.14656-14662
Hauptverfasser: Simon, Marie Francoise, Daviaud, Daniele, Pradere, Jean Philippe, Gres, Sandra, Guigne, Charlotte, Wabitsch, Martin, Chun, Jerold, Valet, Philippe, Saulnier-Blache, Jean Sebastien
Format: Artikel
Sprache:eng
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