Protective Immunity against Disparate Tumors Is Mediated by a Nonpolymorphic MHC Class I Molecule

Current peptide-based immunotherapies for treatment of model cancers target tumor Ags bound by the classical MHC class I (class Ia) molecules. The extensive polymorphism of class Ia loci greatly limits the effectiveness of these approaches. We demonstrate in this study that the murine nonpolymorphic...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-05, Vol.174 (9), p.5367-5374
Hauptverfasser:	Chiang, Eugene Y, Stroynowski, Iwona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - prevention & control Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - prevention & control Cell Line, Tumor Cytotoxicity Tests, Immunologic Epitopes, T-Lymphocyte - immunology Graft Rejection - immunology Graft Rejection - metabolism Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - physiology Immune Tolerance - immunology Liver Neoplasms, Experimental - immunology Liver Neoplasms, Experimental - prevention & control Lymphocyte Activation - immunology Lymphoma, T-Cell - immunology Lymphoma, T-Cell - prevention & control Melanocytes - immunology Melanoma - immunology Melanoma - prevention & control Mice Mice, Inbred C57BL Neoplasm Transplantation - immunology Polymorphism, Genetic - immunology T-Lymphocytes, Cytotoxic - immunology Transfection
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