Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and κ-opioid receptor implicated

Our previous work has demonstrated that 100-Hz electroacupuncture (EA) or 100-Hz transcutaneous electrical nerve stimulation (TENS) was very effective in ameliorating the morphine withdrawal syndrome in rats and humans. The mechanism was obscure. (1) Rats were made dependent on morphine by repeated...

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Veröffentlicht in:	Brain research 1999-12, Vol.851 (1), p.290-296
Hauptverfasser:	Wu, Liu-Zhen, Cui, Cai-Lian, Tian, Jin-Bin, Ji, Dong, Han, Ji-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Animals Biological and medical sciences Body Weight - drug effects Dynorphin Dynorphins - drug effects Dynorphins - metabolism Electroacupuncture Male Medical sciences Morphine - pharmacology Morphine withdrawal Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Neuropharmacology opioid receptors (type ^K) Pain Measurement Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Opioid, kappa - drug effects Receptors, Opioid, kappa - physiology Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - therapy κ-opioid receptor
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