Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography
Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness of VRT in treating subjects with alcohol dependence (AD) by evaluating changes in brain metabolism. The VRT protocol consi...
Gespeichert in:
| Veröffentlicht in: | Journal of studies on alcohol and drugs 2015-07, Vol.76 (4), p.620-627 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 627 |
|---|---|
| container_issue | 4 |
| container_start_page | 620 |
| container_title | Journal of studies on alcohol and drugs |
| container_volume | 76 |
| creator | Son, Ji Hyun Lee, Sang Hoon Seok, Ju Won Kee, Baik Seok Lee, Hyun Woong Kim, Hyung Joon Lee, Tae Kyung Han, Doug Hyun |
| description | Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness of VRT in treating subjects with alcohol dependence (AD) by evaluating changes in brain metabolism.
The VRT protocol consisted of three steps: relaxation, presentation of a high-risk situation, and presentation of an aversive situation. Twelve alcohol-dependent subjects underwent 10 sessions of VRT. The alcohol-dependent subjects were assessed with 18F-fluorodeoxyglucose positron emission tomography images before and after VRT, whereas the control group underwent imaging according to the same protocol only at baseline.
Compared with the healthy control group, AD subjects showed higher metabolism in the right lentiform nucleus and right temporal lobe (BA20) at baseline (P(FDR < .05) = .026). In addition, the metabolism in the left anterior cingulate was lower in subjects with AD (P(uncorr) = .001). After VRT, alcohol-dependent subjects showed decreased brain metabolism in the right lentiform nucleus (P(FDR < .05) = .026) and right temporal lobe (BA38, P(FDR < .05) = .032) relative to that at baseline.
Our results suggest a neurobiological imbalance, notably, a high sensitivity to stimuli, in the limbic system in subjects with AD. Furthermore, we determined that metabolism decreased in the basal ganglia after VRT, which may explain the limbic-regulated responses of reward and regulation. Therefore, we tentatively recommend VRT to treat AD through its regulating effect on limbic circuits. |
| doi_str_mv | 10.15288/jsad.2015.76.620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1749186179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1749186179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-994fc55a4b4f4f0dae3a2f674a8bad7ac03efc08949ccc0108336ec72f4aa9e33</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi1ERUvhAbggS1y4ZGvHjmNzW20LVKrUCi1wjLzOuPEqiYPtIC0PwvPitKVCXHryePTP_DPzIfSGkhWtSinP9lG3q5LQalWLlSjJM3RCFZMFp5Q_v4vrgkopj9HLGPeEVIxS9gIdl4IoSZg6Qb-_uZBm3eMvoHuXDnjbQdDTAVsfcOoAbwPoNMCYsLd43Rvf-R6fwwRjC6OBD3iNbwL0bnCjDgd8Of6EmNytTs6P-LtLHb7x0aWQfxeDi3FJb_3gb7NLdzjb-GGaEwT3C9p_8q_QkdV9hNcP7yn6-vFiu_lcXF1_utysrwrDRJkKpbg1VaX5jltuSauB6dKKmmu5022tDWFgDZGKK2MMoUQyJsDUpeVaK2DsFL2_7zsF_2POkzd5RgN9r0fwc2xozRWVgtbqaalQlFCWzbP03X_SvZ_DmBdZVEwoItjiTe9VJvgYA9hmCm7IR2woae74NgvfZuHb1KLJfHPN24fO826A9rHiL1D2B4NbpLc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1693690633</pqid></control><display><type>article</type><title>Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Sociological Abstracts</source><creator>Son, Ji Hyun ; Lee, Sang Hoon ; Seok, Ju Won ; Kee, Baik Seok ; Lee, Hyun Woong ; Kim, Hyung Joon ; Lee, Tae Kyung ; Han, Doug Hyun</creator><creatorcontrib>Son, Ji Hyun ; Lee, Sang Hoon ; Seok, Ju Won ; Kee, Baik Seok ; Lee, Hyun Woong ; Kim, Hyung Joon ; Lee, Tae Kyung ; Han, Doug Hyun</creatorcontrib><description>Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness of VRT in treating subjects with alcohol dependence (AD) by evaluating changes in brain metabolism.
The VRT protocol consisted of three steps: relaxation, presentation of a high-risk situation, and presentation of an aversive situation. Twelve alcohol-dependent subjects underwent 10 sessions of VRT. The alcohol-dependent subjects were assessed with 18F-fluorodeoxyglucose positron emission tomography images before and after VRT, whereas the control group underwent imaging according to the same protocol only at baseline.
Compared with the healthy control group, AD subjects showed higher metabolism in the right lentiform nucleus and right temporal lobe (BA20) at baseline (P(FDR < .05) = .026). In addition, the metabolism in the left anterior cingulate was lower in subjects with AD (P(uncorr) = .001). After VRT, alcohol-dependent subjects showed decreased brain metabolism in the right lentiform nucleus (P(FDR < .05) = .026) and right temporal lobe (BA38, P(FDR < .05) = .032) relative to that at baseline.
Our results suggest a neurobiological imbalance, notably, a high sensitivity to stimuli, in the limbic system in subjects with AD. Furthermore, we determined that metabolism decreased in the basal ganglia after VRT, which may explain the limbic-regulated responses of reward and regulation. Therefore, we tentatively recommend VRT to treat AD through its regulating effect on limbic circuits.</description><identifier>ISSN: 1937-1888</identifier><identifier>EISSN: 1938-4114</identifier><identifier>DOI: 10.15288/jsad.2015.76.620</identifier><identifier>PMID: 26098039</identifier><identifier>CODEN: JSALDP</identifier><language>eng</language><publisher>United States: Alcohol Research Documentation, Inc</publisher><subject>Adult ; Alcohol use ; Alcoholism - therapy ; Brain ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Gyrus Cinguli ; Humans ; Male ; Metabolism ; Middle Aged ; Positron-Emission Tomography - methods ; Regulation ; Stimuli ; Temporal Lobe ; Tomography ; Tomography, X-Ray Computed - methods ; Virtual Reality ; Virtual Reality Exposure Therapy - methods</subject><ispartof>Journal of studies on alcohol and drugs, 2015-07, Vol.76 (4), p.620-627</ispartof><rights>Copyright Alcohol Research Documentation, Inc. Jul 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-994fc55a4b4f4f0dae3a2f674a8bad7ac03efc08949ccc0108336ec72f4aa9e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,30976,33752</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26098039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Ji Hyun</creatorcontrib><creatorcontrib>Lee, Sang Hoon</creatorcontrib><creatorcontrib>Seok, Ju Won</creatorcontrib><creatorcontrib>Kee, Baik Seok</creatorcontrib><creatorcontrib>Lee, Hyun Woong</creatorcontrib><creatorcontrib>Kim, Hyung Joon</creatorcontrib><creatorcontrib>Lee, Tae Kyung</creatorcontrib><creatorcontrib>Han, Doug Hyun</creatorcontrib><title>Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography</title><title>Journal of studies on alcohol and drugs</title><addtitle>J Stud Alcohol Drugs</addtitle><description>Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness of VRT in treating subjects with alcohol dependence (AD) by evaluating changes in brain metabolism.
The VRT protocol consisted of three steps: relaxation, presentation of a high-risk situation, and presentation of an aversive situation. Twelve alcohol-dependent subjects underwent 10 sessions of VRT. The alcohol-dependent subjects were assessed with 18F-fluorodeoxyglucose positron emission tomography images before and after VRT, whereas the control group underwent imaging according to the same protocol only at baseline.
Compared with the healthy control group, AD subjects showed higher metabolism in the right lentiform nucleus and right temporal lobe (BA20) at baseline (P(FDR < .05) = .026). In addition, the metabolism in the left anterior cingulate was lower in subjects with AD (P(uncorr) = .001). After VRT, alcohol-dependent subjects showed decreased brain metabolism in the right lentiform nucleus (P(FDR < .05) = .026) and right temporal lobe (BA38, P(FDR < .05) = .032) relative to that at baseline.
Our results suggest a neurobiological imbalance, notably, a high sensitivity to stimuli, in the limbic system in subjects with AD. Furthermore, we determined that metabolism decreased in the basal ganglia after VRT, which may explain the limbic-regulated responses of reward and regulation. Therefore, we tentatively recommend VRT to treat AD through its regulating effect on limbic circuits.</description><subject>Adult</subject><subject>Alcohol use</subject><subject>Alcoholism - therapy</subject><subject>Brain</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Gyrus Cinguli</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography - methods</subject><subject>Regulation</subject><subject>Stimuli</subject><subject>Temporal Lobe</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Virtual Reality</subject><subject>Virtual Reality Exposure Therapy - methods</subject><issn>1937-1888</issn><issn>1938-4114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BHHNA</sourceid><recordid>eNqFkcFu1DAQhi1ERUvhAbggS1y4ZGvHjmNzW20LVKrUCi1wjLzOuPEqiYPtIC0PwvPitKVCXHryePTP_DPzIfSGkhWtSinP9lG3q5LQalWLlSjJM3RCFZMFp5Q_v4vrgkopj9HLGPeEVIxS9gIdl4IoSZg6Qb-_uZBm3eMvoHuXDnjbQdDTAVsfcOoAbwPoNMCYsLd43Rvf-R6fwwRjC6OBD3iNbwL0bnCjDgd8Of6EmNytTs6P-LtLHb7x0aWQfxeDi3FJb_3gb7NLdzjb-GGaEwT3C9p_8q_QkdV9hNcP7yn6-vFiu_lcXF1_utysrwrDRJkKpbg1VaX5jltuSauB6dKKmmu5022tDWFgDZGKK2MMoUQyJsDUpeVaK2DsFL2_7zsF_2POkzd5RgN9r0fwc2xozRWVgtbqaalQlFCWzbP03X_SvZ_DmBdZVEwoItjiTe9VJvgYA9hmCm7IR2woae74NgvfZuHb1KLJfHPN24fO826A9rHiL1D2B4NbpLc</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Son, Ji Hyun</creator><creator>Lee, Sang Hoon</creator><creator>Seok, Ju Won</creator><creator>Kee, Baik Seok</creator><creator>Lee, Hyun Woong</creator><creator>Kim, Hyung Joon</creator><creator>Lee, Tae Kyung</creator><creator>Han, Doug Hyun</creator><general>Alcohol Research Documentation, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope><scope>7U3</scope><scope>BHHNA</scope></search><sort><creationdate>201507</creationdate><title>Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography</title><author>Son, Ji Hyun ; Lee, Sang Hoon ; Seok, Ju Won ; Kee, Baik Seok ; Lee, Hyun Woong ; Kim, Hyung Joon ; Lee, Tae Kyung ; Han, Doug Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-994fc55a4b4f4f0dae3a2f674a8bad7ac03efc08949ccc0108336ec72f4aa9e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alcohol use</topic><topic>Alcoholism - therapy</topic><topic>Brain</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Gyrus Cinguli</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography - methods</topic><topic>Regulation</topic><topic>Stimuli</topic><topic>Temporal Lobe</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Virtual Reality</topic><topic>Virtual Reality Exposure Therapy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, Ji Hyun</creatorcontrib><creatorcontrib>Lee, Sang Hoon</creatorcontrib><creatorcontrib>Seok, Ju Won</creatorcontrib><creatorcontrib>Kee, Baik Seok</creatorcontrib><creatorcontrib>Lee, Hyun Woong</creatorcontrib><creatorcontrib>Kim, Hyung Joon</creatorcontrib><creatorcontrib>Lee, Tae Kyung</creatorcontrib><creatorcontrib>Han, Doug Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><jtitle>Journal of studies on alcohol and drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Ji Hyun</au><au>Lee, Sang Hoon</au><au>Seok, Ju Won</au><au>Kee, Baik Seok</au><au>Lee, Hyun Woong</au><au>Kim, Hyung Joon</au><au>Lee, Tae Kyung</au><au>Han, Doug Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography</atitle><jtitle>Journal of studies on alcohol and drugs</jtitle><addtitle>J Stud Alcohol Drugs</addtitle><date>2015-07</date><risdate>2015</risdate><volume>76</volume><issue>4</issue><spage>620</spage><epage>627</epage><pages>620-627</pages><issn>1937-1888</issn><eissn>1938-4114</eissn><coden>JSALDP</coden><abstract>Virtual reality therapy (VRT) uses multimodal stimulation that includes visual, auditory, olfactory, and gustatory stimuli. The aim of this study was to assess the effectiveness of VRT in treating subjects with alcohol dependence (AD) by evaluating changes in brain metabolism.
The VRT protocol consisted of three steps: relaxation, presentation of a high-risk situation, and presentation of an aversive situation. Twelve alcohol-dependent subjects underwent 10 sessions of VRT. The alcohol-dependent subjects were assessed with 18F-fluorodeoxyglucose positron emission tomography images before and after VRT, whereas the control group underwent imaging according to the same protocol only at baseline.
Compared with the healthy control group, AD subjects showed higher metabolism in the right lentiform nucleus and right temporal lobe (BA20) at baseline (P(FDR < .05) = .026). In addition, the metabolism in the left anterior cingulate was lower in subjects with AD (P(uncorr) = .001). After VRT, alcohol-dependent subjects showed decreased brain metabolism in the right lentiform nucleus (P(FDR < .05) = .026) and right temporal lobe (BA38, P(FDR < .05) = .032) relative to that at baseline.
Our results suggest a neurobiological imbalance, notably, a high sensitivity to stimuli, in the limbic system in subjects with AD. Furthermore, we determined that metabolism decreased in the basal ganglia after VRT, which may explain the limbic-regulated responses of reward and regulation. Therefore, we tentatively recommend VRT to treat AD through its regulating effect on limbic circuits.</abstract><cop>United States</cop><pub>Alcohol Research Documentation, Inc</pub><pmid>26098039</pmid><doi>10.15288/jsad.2015.76.620</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1937-1888 |
| ispartof | Journal of studies on alcohol and drugs, 2015-07, Vol.76 (4), p.620-627 |
| issn | 1937-1888 1938-4114 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1749186179 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Alma/SFX Local Collection; Sociological Abstracts |
| subjects | Adult Alcohol use Alcoholism - therapy Brain Female Fluorodeoxyglucose F18 - administration & dosage Gyrus Cinguli Humans Male Metabolism Middle Aged Positron-Emission Tomography - methods Regulation Stimuli Temporal Lobe Tomography Tomography, X-Ray Computed - methods Virtual Reality Virtual Reality Exposure Therapy - methods |
| title | Virtual Reality Therapy for the Treatment of Alcohol Dependence: A Preliminary Investigation With Positron Emission Tomography/Computerized Tomography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T12%3A09%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Virtual%20Reality%20Therapy%20for%20the%20Treatment%20of%20Alcohol%20Dependence:%20A%20Preliminary%20Investigation%20With%20Positron%20Emission%20Tomography/Computerized%20Tomography&rft.jtitle=Journal%20of%20studies%20on%20alcohol%20and%20drugs&rft.au=Son,%20Ji%20Hyun&rft.date=2015-07&rft.volume=76&rft.issue=4&rft.spage=620&rft.epage=627&rft.pages=620-627&rft.issn=1937-1888&rft.eissn=1938-4114&rft.coden=JSALDP&rft_id=info:doi/10.15288/jsad.2015.76.620&rft_dat=%3Cproquest_cross%3E1749186179%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1693690633&rft_id=info:pmid/26098039&rfr_iscdi=true |