Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys

d-Cycloserine, a partial agonist at the glycine recognition site of the N-methyl- d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of d-cycloserine on spat...

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Veröffentlicht in:	Brain research 2000-03, Vol.860 (1), p.190-194
Hauptverfasser:	Schneider, J.S, Tinker, John P, Van Velson, Maria, Giardiniere, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral psychophysiology Biological and medical sciences Cognition Cognition - drug effects Cycloserine - pharmacology Cycloserine - therapeutic use Cycloserine - toxicity D-Cycloserine Discrimination (Psychology) - drug effects Disease Models, Animal Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Excitatory Amino Acid Antagonists - toxicity Fundamental and applied biological sciences. Psychology Glycine Glycine - agonists Glycine - antagonists & inhibitors Macaca fascicularis Male Monkey MPTP MPTP Poisoning - drug therapy MPTP Poisoning - psychology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neuroprotective Agents - toxicity Neurotransmission and behavior NMDA Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Reaction Time - drug effects Visual Perception - drug effects
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