Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys
d-Cycloserine, a partial agonist at the glycine recognition site of the N-methyl- d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of d-cycloserine on spat...
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| Veröffentlicht in: | Brain research 2000-03, Vol.860 (1), p.190-194 |
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| creator | Schneider, J.S Tinker, John P Van Velson, Maria Giardiniere, Michele |
| description | d-Cycloserine, a partial agonist at the glycine recognition site of the
N-methyl-
d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of
d-cycloserine on spatial short-term memory deficits in monkeys induced by chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were examined. Chronic low-dose MPTP administration resulted in deficits in the performance of a variable delayed-response task (VDR). Single administration of
d-cycloserine (320 or 1000 μg/kg) significantly improved the performance on this task. High-dose
d-cycloserine (8000 μg/kg) or MK-801 (10-32 μg/kg) administration had no effects on delayed-response performance but impaired performance on a visual discrimination (VD) task that was not adversely affected by MPTP administration. These results show that at low doses,
d-cycloserine has cognition-enhancing properties in this model of early Parkinsonism. |
| doi_str_mv | 10.1016/S0006-8993(00)02036-9 |
| format | Article |
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N-methyl-
d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of
d-cycloserine on spatial short-term memory deficits in monkeys induced by chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were examined. Chronic low-dose MPTP administration resulted in deficits in the performance of a variable delayed-response task (VDR). Single administration of
d-cycloserine (320 or 1000 μg/kg) significantly improved the performance on this task. High-dose
d-cycloserine (8000 μg/kg) or MK-801 (10-32 μg/kg) administration had no effects on delayed-response performance but impaired performance on a visual discrimination (VD) task that was not adversely affected by MPTP administration. These results show that at low doses,
d-cycloserine has cognition-enhancing properties in this model of early Parkinsonism.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(00)02036-9</identifier><identifier>PMID: 10727642</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Cognition ; Cognition - drug effects ; Cycloserine - pharmacology ; Cycloserine - therapeutic use ; Cycloserine - toxicity ; D-Cycloserine ; Discrimination (Psychology) - drug effects ; Disease Models, Animal ; Dizocilpine Maleate - pharmacology ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Excitatory Amino Acid Antagonists - pharmacology ; Excitatory Amino Acid Antagonists - therapeutic use ; Excitatory Amino Acid Antagonists - toxicity ; Fundamental and applied biological sciences. Psychology ; Glycine ; Glycine - agonists ; Glycine - antagonists & inhibitors ; Macaca fascicularis ; Male ; Monkey ; MPTP ; MPTP Poisoning - drug therapy ; MPTP Poisoning - psychology ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Neuroprotective Agents - toxicity ; Neurotransmission and behavior ; NMDA ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - drug therapy ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - drug effects ; Reaction Time - drug effects ; Visual Perception - drug effects</subject><ispartof>Brain research, 2000-03, Vol.860 (1), p.190-194</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-a796757be58873ae7f279af46de33e5dc80ec199ce501cb9d5463ca19ae90a733</citedby><cites>FETCH-LOGICAL-c487t-a796757be58873ae7f279af46de33e5dc80ec199ce501cb9d5463ca19ae90a733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(00)02036-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1317878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10727642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, J.S</creatorcontrib><creatorcontrib>Tinker, John P</creatorcontrib><creatorcontrib>Van Velson, Maria</creatorcontrib><creatorcontrib>Giardiniere, Michele</creatorcontrib><title>Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>d-Cycloserine, a partial agonist at the glycine recognition site of the
N-methyl-
d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of
d-cycloserine on spatial short-term memory deficits in monkeys induced by chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were examined. Chronic low-dose MPTP administration resulted in deficits in the performance of a variable delayed-response task (VDR). Single administration of
d-cycloserine (320 or 1000 μg/kg) significantly improved the performance on this task. High-dose
d-cycloserine (8000 μg/kg) or MK-801 (10-32 μg/kg) administration had no effects on delayed-response performance but impaired performance on a visual discrimination (VD) task that was not adversely affected by MPTP administration. These results show that at low doses,
d-cycloserine has cognition-enhancing properties in this model of early Parkinsonism.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Cognition - drug effects</subject><subject>Cycloserine - pharmacology</subject><subject>Cycloserine - therapeutic use</subject><subject>Cycloserine - toxicity</subject><subject>D-Cycloserine</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Disease Models, Animal</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Excitatory Amino Acid Antagonists - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine</subject><subject>Glycine - agonists</subject><subject>Glycine - antagonists & inhibitors</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Monkey</subject><subject>MPTP</subject><subject>MPTP Poisoning - drug therapy</subject><subject>MPTP Poisoning - psychology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neuroprotective Agents - toxicity</subject><subject>Neurotransmission and behavior</subject><subject>NMDA</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - drug therapy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Reaction Time - drug effects</subject><subject>Visual Perception - drug effects</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQhonRuOPqT9BwMEYPrdB0Q3MyZrN-JGvcxPVMmKKYRXtgBGbM_HuZnYl688RHPW9ReSDkKWevOePyzVfGmOwmrcVLxl6xngnZ6XtkwSfVd7If2H2y-IOckUelfG9HITR7SM44U72SQ78gu0vvEWqhydN6i3Rjcw12pqt5DyEitasUQ6nUdbCHORXMh9sUKaRVDDXskPpthBoaFlc0tMJtbnugc_pFXQvQz9c3113NaCs6uk7xB-7LY_LA27ngk9N6Tr69v7y5-Nhdffnw6eLdVQfDpGpnlZZqVEscp0kJi8r3Sls_SIdC4OhgYghca8CRcVhqNw5SgOXaomZWCXFOXhz7bnL6ucVSzToUwHm2EdO2GK4GzYdeNnA8gpBTKRm92eSwtnlvODMH4eZOuDnYNIyZO-FGt9yz0wPb5RrdP6mj4QY8PwG2gJ19thFC-csJriY1NeztEcNmYxcwmwIBI6ALuf2PcSn8Z5Lfh5qeaA</recordid><startdate>20000331</startdate><enddate>20000331</enddate><creator>Schneider, J.S</creator><creator>Tinker, John P</creator><creator>Van Velson, Maria</creator><creator>Giardiniere, Michele</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000331</creationdate><title>Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys</title><author>Schneider, J.S ; Tinker, John P ; Van Velson, Maria ; Giardiniere, Michele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-a796757be58873ae7f279af46de33e5dc80ec199ce501cb9d5463ca19ae90a733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Cognition - drug effects</topic><topic>Cycloserine - pharmacology</topic><topic>Cycloserine - therapeutic use</topic><topic>Cycloserine - toxicity</topic><topic>D-Cycloserine</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Disease Models, Animal</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Excitatory Amino Acid Antagonists - toxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine</topic><topic>Glycine - agonists</topic><topic>Glycine - antagonists & inhibitors</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Monkey</topic><topic>MPTP</topic><topic>MPTP Poisoning - drug therapy</topic><topic>MPTP Poisoning - psychology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neuroprotective Agents - toxicity</topic><topic>Neurotransmission and behavior</topic><topic>NMDA</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - drug therapy</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Reaction Time - drug effects</topic><topic>Visual Perception - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, J.S</creatorcontrib><creatorcontrib>Tinker, John P</creatorcontrib><creatorcontrib>Van Velson, Maria</creatorcontrib><creatorcontrib>Giardiniere, Michele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, J.S</au><au>Tinker, John P</au><au>Van Velson, Maria</au><au>Giardiniere, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-03-31</date><risdate>2000</risdate><volume>860</volume><issue>1</issue><spage>190</spage><epage>194</epage><pages>190-194</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>d-Cycloserine, a partial agonist at the glycine recognition site of the
N-methyl-
d-aspartate (NMDA) receptor complex, has been shown to facilitate certain forms of memory formation and to improve visual recognition memory in normal monkeys. In the present study, the effects of
d-cycloserine on spatial short-term memory deficits in monkeys induced by chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration were examined. Chronic low-dose MPTP administration resulted in deficits in the performance of a variable delayed-response task (VDR). Single administration of
d-cycloserine (320 or 1000 μg/kg) significantly improved the performance on this task. High-dose
d-cycloserine (8000 μg/kg) or MK-801 (10-32 μg/kg) administration had no effects on delayed-response performance but impaired performance on a visual discrimination (VD) task that was not adversely affected by MPTP administration. These results show that at low doses,
d-cycloserine has cognition-enhancing properties in this model of early Parkinsonism.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10727642</pmid><doi>10.1016/S0006-8993(00)02036-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Behavioral psychophysiology Biological and medical sciences Cognition Cognition - drug effects Cycloserine - pharmacology Cycloserine - therapeutic use Cycloserine - toxicity D-Cycloserine Discrimination (Psychology) - drug effects Disease Models, Animal Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Excitatory Amino Acid Antagonists - toxicity Fundamental and applied biological sciences. Psychology Glycine Glycine - agonists Glycine - antagonists & inhibitors Macaca fascicularis Male Monkey MPTP MPTP Poisoning - drug therapy MPTP Poisoning - psychology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neuroprotective Agents - toxicity Neurotransmission and behavior NMDA Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Reaction Time - drug effects Visual Perception - drug effects |
| title | Effects of the partial glycine agonist d-cycloserine on cognitive functioning in chronic low dose MPTP-treated monkeys |
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