A proteomics approach to identify changes in protein profiles in pre-cancerous colon
The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells. Early detection is an important factor in decreasing colon cancer deaths. Proteomic techniques were used to identi...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2005-04, Vol.330 (1), p.81-87 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 87 |
|---|---|
| container_issue | 1 |
| container_start_page | 81 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 330 |
| creator | Drew, Janice E. Rucklidge, Garry J. Duncan, Gary Lufty, Awni Farquharson, Andrew J. Reid, Martin D. Russell, Wendy R. Morrice, Philip C. Arthur, John R. Duthie, Garry G. |
| description | The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells. Early detection is an important factor in decreasing colon cancer deaths. Proteomic techniques were used to identify potential early markers in colon tissue exhibiting pre-cancerous activity that may characterise pathological changes in a chemically induced colon cancer rat model. Protein profiles were assessed in soluble and insoluble fractions prepared from distal colon of rats treated with the colonotropic carcinogen, dimethylhydrazine. Alterations in protein profiles were associated with the presence of aberrant crypt foci, hyperplasia and dysplasia, microanatomical changes, and metabolic changes in rat colon. These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis. |
| doi_str_mv | 10.1016/j.bbrc.2005.02.125 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17489171</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X05003918</els_id><sourcerecordid>17489171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-44ae90a28240f602ef3bb995d8b37646c4a3de56703ac013c5d6c20798710bce3</originalsourceid><addsrcrecordid>eNp9kE1LxEAMhgdRdF39Ax6kJ2-tyXT6BV5E_IIFLwrehmmaurN023WmK_jvnaUr3jyFhCcvySPEBUKCgPn1KqlrR4kEyBKQCcrsQMwQKoglgjoUMwDIY1nh-4k49X4FgKjy6licYFaUKNNsJl5vo40bRh7WlnxkNqExtIzGIbIN96NtvyNamv6DfWT7CZ1qa7vfGcdkemI3bH1EQzf0Z-KoNZ3n832di7eH-9e7p3jx8vh8d7uISWU4xkoZrsDIUipoc5DcpnVdVVlT1mmRq5yUSRvO8gJSQ4ApZU1OEoqqLBBq4nQurqbccM_nlv2o19YTd53pORyjsVBlhQUGUE4gucF7x63eOLs27lsj6J1LvdI7l3rnUoPUwWVYutynb-s1N38re3kBuJkADj9-WXbak-VgorGOadTNYP_L_wHaIoVk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17489171</pqid></control><display><type>article</type><title>A proteomics approach to identify changes in protein profiles in pre-cancerous colon</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Drew, Janice E. ; Rucklidge, Garry J. ; Duncan, Gary ; Lufty, Awni ; Farquharson, Andrew J. ; Reid, Martin D. ; Russell, Wendy R. ; Morrice, Philip C. ; Arthur, John R. ; Duthie, Garry G.</creator><creatorcontrib>Drew, Janice E. ; Rucklidge, Garry J. ; Duncan, Gary ; Lufty, Awni ; Farquharson, Andrew J. ; Reid, Martin D. ; Russell, Wendy R. ; Morrice, Philip C. ; Arthur, John R. ; Duthie, Garry G.</creatorcontrib><description>The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells. Early detection is an important factor in decreasing colon cancer deaths. Proteomic techniques were used to identify potential early markers in colon tissue exhibiting pre-cancerous activity that may characterise pathological changes in a chemically induced colon cancer rat model. Protein profiles were assessed in soluble and insoluble fractions prepared from distal colon of rats treated with the colonotropic carcinogen, dimethylhydrazine. Alterations in protein profiles were associated with the presence of aberrant crypt foci, hyperplasia and dysplasia, microanatomical changes, and metabolic changes in rat colon. These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2005.02.125</identifier><identifier>PMID: 15781235</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aberrant crypt foci ; Animals ; Carcinogens - administration & dosage ; Chromatography, Liquid ; Colon cancer ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Dimethylhydrazines - administration & dosage ; Disease Models, Animal ; Electrophoresis, Gel, Two-Dimensional ; Homeostasis ; Male ; Neoplasm Proteins - metabolism ; Precancerous Conditions - metabolism ; Precancerous Conditions - pathology ; Prostaglandin ; Proteomics ; Rat ; Rats ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Weight Gain - drug effects</subject><ispartof>Biochemical and biophysical research communications, 2005-04, Vol.330 (1), p.81-87</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-44ae90a28240f602ef3bb995d8b37646c4a3de56703ac013c5d6c20798710bce3</citedby><cites>FETCH-LOGICAL-c451t-44ae90a28240f602ef3bb995d8b37646c4a3de56703ac013c5d6c20798710bce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X05003918$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15781235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drew, Janice E.</creatorcontrib><creatorcontrib>Rucklidge, Garry J.</creatorcontrib><creatorcontrib>Duncan, Gary</creatorcontrib><creatorcontrib>Lufty, Awni</creatorcontrib><creatorcontrib>Farquharson, Andrew J.</creatorcontrib><creatorcontrib>Reid, Martin D.</creatorcontrib><creatorcontrib>Russell, Wendy R.</creatorcontrib><creatorcontrib>Morrice, Philip C.</creatorcontrib><creatorcontrib>Arthur, John R.</creatorcontrib><creatorcontrib>Duthie, Garry G.</creatorcontrib><title>A proteomics approach to identify changes in protein profiles in pre-cancerous colon</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells. Early detection is an important factor in decreasing colon cancer deaths. Proteomic techniques were used to identify potential early markers in colon tissue exhibiting pre-cancerous activity that may characterise pathological changes in a chemically induced colon cancer rat model. Protein profiles were assessed in soluble and insoluble fractions prepared from distal colon of rats treated with the colonotropic carcinogen, dimethylhydrazine. Alterations in protein profiles were associated with the presence of aberrant crypt foci, hyperplasia and dysplasia, microanatomical changes, and metabolic changes in rat colon. These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis.</description><subject>Aberrant crypt foci</subject><subject>Animals</subject><subject>Carcinogens - administration & dosage</subject><subject>Chromatography, Liquid</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Dimethylhydrazines - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Electrophoresis, Gel, Two-Dimensional</subject><subject>Homeostasis</subject><subject>Male</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Precancerous Conditions - metabolism</subject><subject>Precancerous Conditions - pathology</subject><subject>Prostaglandin</subject><subject>Proteomics</subject><subject>Rat</subject><subject>Rats</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Weight Gain - drug effects</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxEAMhgdRdF39Ax6kJ2-tyXT6BV5E_IIFLwrehmmaurN023WmK_jvnaUr3jyFhCcvySPEBUKCgPn1KqlrR4kEyBKQCcrsQMwQKoglgjoUMwDIY1nh-4k49X4FgKjy6licYFaUKNNsJl5vo40bRh7WlnxkNqExtIzGIbIN96NtvyNamv6DfWT7CZ1qa7vfGcdkemI3bH1EQzf0Z-KoNZ3n832di7eH-9e7p3jx8vh8d7uISWU4xkoZrsDIUipoc5DcpnVdVVlT1mmRq5yUSRvO8gJSQ4ApZU1OEoqqLBBq4nQurqbccM_nlv2o19YTd53pORyjsVBlhQUGUE4gucF7x63eOLs27lsj6J1LvdI7l3rnUoPUwWVYutynb-s1N38re3kBuJkADj9-WXbak-VgorGOadTNYP_L_wHaIoVk</recordid><startdate>20050429</startdate><enddate>20050429</enddate><creator>Drew, Janice E.</creator><creator>Rucklidge, Garry J.</creator><creator>Duncan, Gary</creator><creator>Lufty, Awni</creator><creator>Farquharson, Andrew J.</creator><creator>Reid, Martin D.</creator><creator>Russell, Wendy R.</creator><creator>Morrice, Philip C.</creator><creator>Arthur, John R.</creator><creator>Duthie, Garry G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20050429</creationdate><title>A proteomics approach to identify changes in protein profiles in pre-cancerous colon</title><author>Drew, Janice E. ; Rucklidge, Garry J. ; Duncan, Gary ; Lufty, Awni ; Farquharson, Andrew J. ; Reid, Martin D. ; Russell, Wendy R. ; Morrice, Philip C. ; Arthur, John R. ; Duthie, Garry G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-44ae90a28240f602ef3bb995d8b37646c4a3de56703ac013c5d6c20798710bce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aberrant crypt foci</topic><topic>Animals</topic><topic>Carcinogens - administration & dosage</topic><topic>Chromatography, Liquid</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Dimethylhydrazines - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Electrophoresis, Gel, Two-Dimensional</topic><topic>Homeostasis</topic><topic>Male</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Precancerous Conditions - metabolism</topic><topic>Precancerous Conditions - pathology</topic><topic>Prostaglandin</topic><topic>Proteomics</topic><topic>Rat</topic><topic>Rats</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drew, Janice E.</creatorcontrib><creatorcontrib>Rucklidge, Garry J.</creatorcontrib><creatorcontrib>Duncan, Gary</creatorcontrib><creatorcontrib>Lufty, Awni</creatorcontrib><creatorcontrib>Farquharson, Andrew J.</creatorcontrib><creatorcontrib>Reid, Martin D.</creatorcontrib><creatorcontrib>Russell, Wendy R.</creatorcontrib><creatorcontrib>Morrice, Philip C.</creatorcontrib><creatorcontrib>Arthur, John R.</creatorcontrib><creatorcontrib>Duthie, Garry G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drew, Janice E.</au><au>Rucklidge, Garry J.</au><au>Duncan, Gary</au><au>Lufty, Awni</au><au>Farquharson, Andrew J.</au><au>Reid, Martin D.</au><au>Russell, Wendy R.</au><au>Morrice, Philip C.</au><au>Arthur, John R.</au><au>Duthie, Garry G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A proteomics approach to identify changes in protein profiles in pre-cancerous colon</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2005-04-29</date><risdate>2005</risdate><volume>330</volume><issue>1</issue><spage>81</spage><epage>87</epage><pages>81-87</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The development of colon cancer is characterised by alterations in multiple genetic and epigenetic pathways in colon tissue leading ultimately to deregulation of colon epithelial cells. Early detection is an important factor in decreasing colon cancer deaths. Proteomic techniques were used to identify potential early markers in colon tissue exhibiting pre-cancerous activity that may characterise pathological changes in a chemically induced colon cancer rat model. Protein profiles were assessed in soluble and insoluble fractions prepared from distal colon of rats treated with the colonotropic carcinogen, dimethylhydrazine. Alterations in protein profiles were associated with the presence of aberrant crypt foci, hyperplasia and dysplasia, microanatomical changes, and metabolic changes in rat colon. These changes may have a potential role in the identification of pre-pathological features preceding colon tumorigenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15781235</pmid><doi>10.1016/j.bbrc.2005.02.125</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2005-04, Vol.330 (1), p.81-87 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17489171 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aberrant crypt foci Animals Carcinogens - administration & dosage Chromatography, Liquid Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dimethylhydrazines - administration & dosage Disease Models, Animal Electrophoresis, Gel, Two-Dimensional Homeostasis Male Neoplasm Proteins - metabolism Precancerous Conditions - metabolism Precancerous Conditions - pathology Prostaglandin Proteomics Rat Rats Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Weight Gain - drug effects |
| title | A proteomics approach to identify changes in protein profiles in pre-cancerous colon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T01%3A47%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20proteomics%20approach%20to%20identify%20changes%20in%20protein%20profiles%20in%20pre-cancerous%20colon&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Drew,%20Janice%20E.&rft.date=2005-04-29&rft.volume=330&rft.issue=1&rft.spage=81&rft.epage=87&rft.pages=81-87&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2005.02.125&rft_dat=%3Cproquest_cross%3E17489171%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17489171&rft_id=info:pmid/15781235&rft_els_id=S0006291X05003918&rfr_iscdi=true |