The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia

The free radical scavenger edaravone has been used as an anti-oxidative agent in acute ischemic brain disorders. We examined the effect of edaravone on the production of nitric oxide (NO), reactive oxygen species (ROS) and proinflammatory cytokines by activated microglia, and we also examined its ne...

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Veröffentlicht in:	Neuropharmacology 2005-02, Vol.48 (2), p.283-290
Hauptverfasser:	Banno, Masahiro, Mizuno, Tetsuya, Kato, Hideki, Zhang, Guiqin, Kawanokuchi, Jun, Wang, Jinyan, Kuno, Reiko, Jin, Shijie, Takeuchi, Hideyuki, Suzumura, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipyrine - analogs & derivatives Antipyrine - pharmacology Cells, Cultured Dose-Response Relationship, Drug Edaravone Free radical scavenger Free Radical Scavengers - pharmacology Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - metabolism Neuroprotective Agents - pharmacology Neurotoxicity Nitric oxide Oxidative Stress - drug effects Oxidative Stress - physiology Peroxynitrite Peroxynitrous Acid - antagonists & inhibitors Peroxynitrous Acid - toxicity
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