Toluene inhalation induced epididymal sperm dysfunction in rats
Toluene is a widely abused inhaled solvent. This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague–Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Ex...
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| Veröffentlicht in: | Toxicology (Amsterdam) 1999-12, Vol.139 (3), p.193-205 |
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| creator | Ono, Atsushi Kawashima, Kunio Sekita, Kiyoshi Hirose, Akihiko Ogawa, Yukio Saito, Minoru Naito, Katsushi Yasuhara, Kazuo Kaneko, Toyozo Furuya, Tsuyoshi Inoue, Tohru Kurokawa, Yuji |
| description | Toluene is a widely abused inhaled solvent. This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague–Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related suppression of body weight gain and food consumption were observed. Salivation and lacrimation were observed during exposure periods and intensified with repeated exposure. Rats exposed to 6000 ppm toluene had decreased spleen and thymus weights, as well as suppressed lymphocyte counts. In 6000 ppm group, the epididymal sperm counts, sperm motility, sperm quality and in vitro penetrating ability to zona-free hamster eggs were significantly reduced, while no exposure-related changes in the testes weight or spermatogenesis within testes were detected. Tail-less sperm heads were seen within zona-free eggs incubated with sperm from rats exposed to 6000 ppm toluene, but not control rats. No significant changes were observed in serum luteinizing hormone, follicle-stimulating hormone, or testosterone levels following 1 month of exposure to 6000 ppm toluene. These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation. |
| doi_str_mv | 10.1016/S0300-483X(99)00120-1 |
| format | Article |
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This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague–Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related suppression of body weight gain and food consumption were observed. Salivation and lacrimation were observed during exposure periods and intensified with repeated exposure. Rats exposed to 6000 ppm toluene had decreased spleen and thymus weights, as well as suppressed lymphocyte counts. In 6000 ppm group, the epididymal sperm counts, sperm motility, sperm quality and in vitro penetrating ability to zona-free hamster eggs were significantly reduced, while no exposure-related changes in the testes weight or spermatogenesis within testes were detected. Tail-less sperm heads were seen within zona-free eggs incubated with sperm from rats exposed to 6000 ppm toluene, but not control rats. No significant changes were observed in serum luteinizing hormone, follicle-stimulating hormone, or testosterone levels following 1 month of exposure to 6000 ppm toluene. These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(99)00120-1</identifier><identifier>PMID: 10647920</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague–Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related suppression of body weight gain and food consumption were observed. Salivation and lacrimation were observed during exposure periods and intensified with repeated exposure. Rats exposed to 6000 ppm toluene had decreased spleen and thymus weights, as well as suppressed lymphocyte counts. In 6000 ppm group, the epididymal sperm counts, sperm motility, sperm quality and in vitro penetrating ability to zona-free hamster eggs were significantly reduced, while no exposure-related changes in the testes weight or spermatogenesis within testes were detected. Tail-less sperm heads were seen within zona-free eggs incubated with sperm from rats exposed to 6000 ppm toluene, but not control rats. No significant changes were observed in serum luteinizing hormone, follicle-stimulating hormone, or testosterone levels following 1 month of exposure to 6000 ppm toluene. These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cholinesterases - blood</subject><subject>Cricetinae</subject><subject>Epididymal sperm maturation</subject><subject>Epididymis - drug effects</subject><subject>Female</subject><subject>Fertility</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Inhalation</subject><subject>Inhalation Exposure</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Solvents</subject><subject>Solvents - toxicity</subject><subject>Sperm Count - drug effects</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatogenesis - drug effects</subject><subject>Spermatozoa - drug effects</subject><subject>Testosterone - blood</subject><subject>Toluene - toxicity</subject><subject>Toluene abuse</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKxEAQhhtRdFweQclBRA_R6i1JnwYRNxA8OIK3ptNdwZYsY3cizNubWVBvnqoO3_9X8RFyTOGSAs2uXoADpKLgb-dKXQBQBindIhNa5CrltJDbZPKD7JH9GD8AgHGR7ZI9CpnIFYMJmc66esAWE9--m9r0vmvH1Q0WXYJz77xbNKZO4hxDk7hFrIbWbqAkmD4ekp3K1BGPNvOAvN7dzm4e0qfn-8eb66fUCsn6lBU2E8gNM6WlXFnIlCorg5ahyWUplVOASqnKIausdSKXosCqFCV1soSCH5Czde88dJ8Dxl43Plqsa9NiN0RNc1EA59n_4PhPJqgcQbkGbehiDFjpefCNCQtNQS8V65VivfSnldIrxZqOuZPNgaFs0P1JrZ2OwOkGMNGaugqmtT7-ckxykMue6RrDUduXx6Cj9diO4n1A22vX-X8--QYwo5jt</recordid><startdate>19991206</startdate><enddate>19991206</enddate><creator>Ono, Atsushi</creator><creator>Kawashima, Kunio</creator><creator>Sekita, Kiyoshi</creator><creator>Hirose, Akihiko</creator><creator>Ogawa, Yukio</creator><creator>Saito, Minoru</creator><creator>Naito, Katsushi</creator><creator>Yasuhara, Kazuo</creator><creator>Kaneko, Toyozo</creator><creator>Furuya, Tsuyoshi</creator><creator>Inoue, Tohru</creator><creator>Kurokawa, Yuji</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>19991206</creationdate><title>Toluene inhalation induced epididymal sperm dysfunction in rats</title><author>Ono, Atsushi ; Kawashima, Kunio ; Sekita, Kiyoshi ; Hirose, Akihiko ; Ogawa, Yukio ; Saito, Minoru ; Naito, Katsushi ; Yasuhara, Kazuo ; Kaneko, Toyozo ; Furuya, Tsuyoshi ; Inoue, Tohru ; Kurokawa, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-28c64e3a2abc139c0699bfaec2ea75b59d90e999fde2fccd47548efb4b1d5b083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cholinesterases - blood</topic><topic>Cricetinae</topic><topic>Epididymal sperm maturation</topic><topic>Epididymis - drug effects</topic><topic>Female</topic><topic>Fertility</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Inhalation</topic><topic>Inhalation Exposure</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Solvents</topic><topic>Solvents - toxicity</topic><topic>Sperm Count - drug effects</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatogenesis - drug effects</topic><topic>Spermatozoa - drug effects</topic><topic>Testosterone - blood</topic><topic>Toluene - toxicity</topic><topic>Toluene abuse</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ono, Atsushi</creatorcontrib><creatorcontrib>Kawashima, Kunio</creatorcontrib><creatorcontrib>Sekita, Kiyoshi</creatorcontrib><creatorcontrib>Hirose, Akihiko</creatorcontrib><creatorcontrib>Ogawa, Yukio</creatorcontrib><creatorcontrib>Saito, Minoru</creatorcontrib><creatorcontrib>Naito, Katsushi</creatorcontrib><creatorcontrib>Yasuhara, Kazuo</creatorcontrib><creatorcontrib>Kaneko, Toyozo</creatorcontrib><creatorcontrib>Furuya, Tsuyoshi</creatorcontrib><creatorcontrib>Inoue, Tohru</creatorcontrib><creatorcontrib>Kurokawa, Yuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ono, Atsushi</au><au>Kawashima, Kunio</au><au>Sekita, Kiyoshi</au><au>Hirose, Akihiko</au><au>Ogawa, Yukio</au><au>Saito, Minoru</au><au>Naito, Katsushi</au><au>Yasuhara, Kazuo</au><au>Kaneko, Toyozo</au><au>Furuya, Tsuyoshi</au><au>Inoue, Tohru</au><au>Kurokawa, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toluene inhalation induced epididymal sperm dysfunction in rats</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>1999-12-06</date><risdate>1999</risdate><volume>139</volume><issue>3</issue><spage>193</spage><epage>205</epage><pages>193-205</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>Toluene is a widely abused inhaled solvent. This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague–Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related suppression of body weight gain and food consumption were observed. Salivation and lacrimation were observed during exposure periods and intensified with repeated exposure. Rats exposed to 6000 ppm toluene had decreased spleen and thymus weights, as well as suppressed lymphocyte counts. In 6000 ppm group, the epididymal sperm counts, sperm motility, sperm quality and in vitro penetrating ability to zona-free hamster eggs were significantly reduced, while no exposure-related changes in the testes weight or spermatogenesis within testes were detected. Tail-less sperm heads were seen within zona-free eggs incubated with sperm from rats exposed to 6000 ppm toluene, but not control rats. No significant changes were observed in serum luteinizing hormone, follicle-stimulating hormone, or testosterone levels following 1 month of exposure to 6000 ppm toluene. These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10647920</pmid><doi>10.1016/S0300-483X(99)00120-1</doi><tpages>13</tpages></addata></record> |
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| ispartof | Toxicology (Amsterdam), 1999-12, Vol.139 (3), p.193-205 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cholinesterases - blood Cricetinae Epididymal sperm maturation Epididymis - drug effects Female Fertility Follicle Stimulating Hormone - blood Inhalation Inhalation Exposure Luteinizing Hormone - blood Male Medical sciences Rats Rats, Sprague-Dawley Solvents Solvents - toxicity Sperm Count - drug effects Sperm Motility - drug effects Spermatogenesis - drug effects Spermatozoa - drug effects Testosterone - blood Toluene - toxicity Toluene abuse Toxicology |
| title | Toluene inhalation induced epididymal sperm dysfunction in rats |
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