FGF‐2 isoforms of 18 and 22.5 kDa differentially modulate t‐PA and PAI‐1 expressions on the pancreatic carcinoma cells AR4–2J: Consequences on cell spreading and invasion

Pancreatic tumors overexpress FGF‐2 and t‐PA, but the implication of the growth factor in t‐PA synthesis and t‐PA‐dependent tumor invasion remains unknown. FGF‐2 is present in different isoforms: The 18 kDa FGF‐2 is secreted, while the 22.5 kDa one is nuclearized and exerts intracrine regulations by...

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Veröffentlicht in:	International journal of cancer 2000-02, Vol.85 (4), p.555-562
Hauptverfasser:	Escaffit, Fabrice, Estival, Agnès, Bertrand, Claudine, Vaysse, Nicole, Hollande, Etienne, Clemente, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Collagen Doxycycline - toxicity Drug Combinations Extracellular Matrix Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - pharmacology Fibroblast Growth Factor 2 - physiology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - drug effects Kinetics Laminin Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Nude Molecular Weight Mutagenesis, Site-Directed Neoplasm Invasiveness Neoplasm Metastasis PAI-1 protein Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Plasminogen Activator Inhibitor 1 - genetics Point Mutation Protein Isoforms - genetics Protein Isoforms - physiology Proteoglycans Rats Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Tissue Plasminogen Activator - genetics Transcription, Genetic Transfection Transplantation, Heterologous Tumor Cells, Cultured Tumors Urokinase-Type Plasminogen Activator - genetics
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