Chronic Toxicity and Reversibility of Antifertility Effect of Immunization against Gonadotropin-Releasing Hormone in Male Rats and Rabbits

The chronic systemic toxicity of immunization with gonadotropin-releasing hormone, conjugated to tetanus toxoid (GnRH-TT), was investigated in male rats and rabbits in order to start Phase I clinical trials. Groups of rats and rabbits were immunized with GnRH-TT dissolved in aqueous adjuvant. The an...

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Veröffentlicht in:	Toxicological sciences 2000-01, Vol.53 (1), p.92-92
Hauptverfasser:	Kumar, Narender, Savage, Toyin, DeJesus, William, Tsong, Y. Y., Didolkar, A., Sundaram, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Chemical Analysis Body Weight - drug effects Contraceptive Agents, Male - toxicity Female Fertility - drug effects GnRH Gonadotropin-Releasing Hormone - blood Gonadotropin-Releasing Hormone - immunology Gonadotropin-Releasing Hormone - toxicity Hematologic Tests Hormones. Endocrine system Immunization Male Medical sciences Organ Size - drug effects Pharmacology. Drug treatments pituitary response Rabbits Rats Recovery of Function reversibility Testosterone - blood tetanus toxin Tetanus Toxin - toxicity toxicity Toxicity Tests
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