Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis
The lateral hypothalamic area, containing orexin neurons, is involved in several aspects of autonomic regulation, including thermoregulation and energy expenditure. To determine if activation of lateral hypothalamic area neurons influences sympathetically-regulated thermogenesis in brown adipose tis...
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| Veröffentlicht in: | Neuroscience 2005, Vol.135 (2), p.627-638 |
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| description | The lateral hypothalamic area, containing orexin neurons, is involved in several aspects of autonomic regulation, including thermoregulation and energy expenditure. To determine if activation of lateral hypothalamic area neurons influences sympathetically-regulated thermogenesis in brown adipose tissue, we microinjected bicuculline (120pmol, 60nl, unilateral) into the lateral hypothalamic area in urethane/chloralose-anesthetized, artificially-ventilated rats. Disinhibition of neurons in lateral hypothalamic area evoked a significant increase (+1309%) in brown adipose tissue sympathetic nerve activity accompanied by parallel increases in brown adipose tissue temperature (+2.0°C), in expired CO
2 (+0.6%), in heart rate (+88 bpm) and in mean arterial pressure (+11 mm Hg). Subsequent microinjections of glycine (30nmol, 60nl) to inhibit local neurons in raphe pallidus or in dorsomedial hypothalamus or of glutamate receptor antagonists into dorsomedial hypothalamus promptly reversed the increases in brown adipose tissue sympathetic nerve activity, brown adipose tissue temperature and heart rate evoked by disinhibition of neurons in lateral hypothalamic area. We conclude that neurons in the lateral hypothalamic area can influence brown adipose tissue sympathetic nerve activity, brown adipose tissue thermogenesis and heart rate through pathways that are dependent on the activation of neurons in dorsomedial hypothalamus and raphe pallidus. |
| doi_str_mv | 10.1016/j.neuroscience.2005.06.039 |
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2 (+0.6%), in heart rate (+88 bpm) and in mean arterial pressure (+11 mm Hg). Subsequent microinjections of glycine (30nmol, 60nl) to inhibit local neurons in raphe pallidus or in dorsomedial hypothalamus or of glutamate receptor antagonists into dorsomedial hypothalamus promptly reversed the increases in brown adipose tissue sympathetic nerve activity, brown adipose tissue temperature and heart rate evoked by disinhibition of neurons in lateral hypothalamic area. We conclude that neurons in the lateral hypothalamic area can influence brown adipose tissue sympathetic nerve activity, brown adipose tissue thermogenesis and heart rate through pathways that are dependent on the activation of neurons in dorsomedial hypothalamus and raphe pallidus.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2005.06.039</identifier><identifier>PMID: 16125857</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>2-Amino-5-phosphonovalerate - pharmacology ; 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology ; Adipose Tissue, Brown - physiology ; Animals ; bicuculline ; Bicuculline - pharmacology ; Biological and medical sciences ; Carbon Dioxide - pharmacology ; dorsomedial hypothalamus ; Drug Interactions ; Electric Stimulation - methods ; Evoked Potentials - drug effects ; Evoked Potentials - physiology ; Evoked Potentials - radiation effects ; Excitatory Amino Acid Antagonists - pharmacology ; Fundamental and applied biological sciences. Psychology ; GABA Antagonists - pharmacology ; Heart Rate - drug effects ; Hypothalamic Area, Lateral - cytology ; Hypothalamic Area, Lateral - drug effects ; Microinjections - methods ; Neural Inhibition - drug effects ; Neural Inhibition - physiology ; Neural Inhibition - radiation effects ; Neurons - drug effects ; Neurons - physiology ; orexin ; Raphe Nuclei - drug effects ; raphe pallidus ; Rats ; Rats, Sprague-Dawley ; sympathetic nerve activity ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Thermogenesis - physiology ; thermoregulation ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Neuroscience, 2005, Vol.135 (2), p.627-638</ispartof><rights>2005 IBRO</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-ce6c3336da6fe3dc99dae7686059f9eeb34f26403ae9aefde507ee9ec44db85a3</citedby><cites>FETCH-LOGICAL-c505t-ce6c3336da6fe3dc99dae7686059f9eeb34f26403ae9aefde507ee9ec44db85a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2005.06.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17178568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16125857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cerri, M.</creatorcontrib><creatorcontrib>Morrison, S.F.</creatorcontrib><title>Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The lateral hypothalamic area, containing orexin neurons, is involved in several aspects of autonomic regulation, including thermoregulation and energy expenditure. To determine if activation of lateral hypothalamic area neurons influences sympathetically-regulated thermogenesis in brown adipose tissue, we microinjected bicuculline (120pmol, 60nl, unilateral) into the lateral hypothalamic area in urethane/chloralose-anesthetized, artificially-ventilated rats. Disinhibition of neurons in lateral hypothalamic area evoked a significant increase (+1309%) in brown adipose tissue sympathetic nerve activity accompanied by parallel increases in brown adipose tissue temperature (+2.0°C), in expired CO
2 (+0.6%), in heart rate (+88 bpm) and in mean arterial pressure (+11 mm Hg). Subsequent microinjections of glycine (30nmol, 60nl) to inhibit local neurons in raphe pallidus or in dorsomedial hypothalamus or of glutamate receptor antagonists into dorsomedial hypothalamus promptly reversed the increases in brown adipose tissue sympathetic nerve activity, brown adipose tissue temperature and heart rate evoked by disinhibition of neurons in lateral hypothalamic area. We conclude that neurons in the lateral hypothalamic area can influence brown adipose tissue sympathetic nerve activity, brown adipose tissue thermogenesis and heart rate through pathways that are dependent on the activation of neurons in dorsomedial hypothalamus and raphe pallidus.</description><subject>2-Amino-5-phosphonovalerate - pharmacology</subject><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</subject><subject>Adipose Tissue, Brown - physiology</subject><subject>Animals</subject><subject>bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - pharmacology</subject><subject>dorsomedial hypothalamus</subject><subject>Drug Interactions</subject><subject>Electric Stimulation - methods</subject><subject>Evoked Potentials - drug effects</subject><subject>Evoked Potentials - physiology</subject><subject>Evoked Potentials - radiation effects</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA Antagonists - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Hypothalamic Area, Lateral - cytology</subject><subject>Hypothalamic Area, Lateral - drug effects</subject><subject>Microinjections - methods</subject><subject>Neural Inhibition - drug effects</subject><subject>Neural Inhibition - physiology</subject><subject>Neural Inhibition - radiation effects</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>orexin</subject><subject>Raphe Nuclei - drug effects</subject><subject>raphe pallidus</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>sympathetic nerve activity</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Thermogenesis - physiology</subject><subject>thermoregulation</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi1ERbeFv4AiJLglteOvhFtVKCBV6gUkbpbXnrBeJfHicYr67-tlI5Ujc5nL8847egh5x2jDKFNX-2aGJUV0AWYHTUupbKhqKO9fkA3rNK-1FOIl2VBOVS1k256TC8Q9LSMFf0XOmWKt7KTekJ_XLocHm0OcqzhUo82Q7FjtHg8x7-xop-Cqv20zVpjDtBwJrLYp_pkr68MhIlQ5IC5l7SBN8RfMgAFfk7PBjghv1n1Jftx-_n7ztb67__Lt5vqudpLKXDtQjnOuvFUDcO_63lvQqlNU9kMPsOViaJWg3EJvYfAgqQbowQnht520_JJ8ON09pPh7AcxmCuhgHO0McUHDtNCKK1nAjyfQFXWYYDCHFCabHg2j5ujV7M2_Xs3Rq6HKFK8l_HZtWbYT-OfoKrIA71fAorPjkOzsAj5zmulOqq5wn04cFCcPAZJZ63xI4LLxMfzPP09IqaEb</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Cerri, M.</creator><creator>Morrison, S.F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>2005</creationdate><title>Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis</title><author>Cerri, M. ; Morrison, S.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-ce6c3336da6fe3dc99dae7686059f9eeb34f26403ae9aefde507ee9ec44db85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2-Amino-5-phosphonovalerate - pharmacology</topic><topic>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</topic><topic>Adipose Tissue, Brown - physiology</topic><topic>Animals</topic><topic>bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - pharmacology</topic><topic>dorsomedial hypothalamus</topic><topic>Drug Interactions</topic><topic>Electric Stimulation - methods</topic><topic>Evoked Potentials - drug effects</topic><topic>Evoked Potentials - physiology</topic><topic>Evoked Potentials - radiation effects</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA Antagonists - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Hypothalamic Area, Lateral - cytology</topic><topic>Hypothalamic Area, Lateral - drug effects</topic><topic>Microinjections - methods</topic><topic>Neural Inhibition - drug effects</topic><topic>Neural Inhibition - physiology</topic><topic>Neural Inhibition - radiation effects</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>orexin</topic><topic>Raphe Nuclei - drug effects</topic><topic>raphe pallidus</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>sympathetic nerve activity</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Thermogenesis - physiology</topic><topic>thermoregulation</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cerri, M.</creatorcontrib><creatorcontrib>Morrison, S.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cerri, M.</au><au>Morrison, S.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2005</date><risdate>2005</risdate><volume>135</volume><issue>2</issue><spage>627</spage><epage>638</epage><pages>627-638</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The lateral hypothalamic area, containing orexin neurons, is involved in several aspects of autonomic regulation, including thermoregulation and energy expenditure. To determine if activation of lateral hypothalamic area neurons influences sympathetically-regulated thermogenesis in brown adipose tissue, we microinjected bicuculline (120pmol, 60nl, unilateral) into the lateral hypothalamic area in urethane/chloralose-anesthetized, artificially-ventilated rats. Disinhibition of neurons in lateral hypothalamic area evoked a significant increase (+1309%) in brown adipose tissue sympathetic nerve activity accompanied by parallel increases in brown adipose tissue temperature (+2.0°C), in expired CO
2 (+0.6%), in heart rate (+88 bpm) and in mean arterial pressure (+11 mm Hg). Subsequent microinjections of glycine (30nmol, 60nl) to inhibit local neurons in raphe pallidus or in dorsomedial hypothalamus or of glutamate receptor antagonists into dorsomedial hypothalamus promptly reversed the increases in brown adipose tissue sympathetic nerve activity, brown adipose tissue temperature and heart rate evoked by disinhibition of neurons in lateral hypothalamic area. We conclude that neurons in the lateral hypothalamic area can influence brown adipose tissue sympathetic nerve activity, brown adipose tissue thermogenesis and heart rate through pathways that are dependent on the activation of neurons in dorsomedial hypothalamus and raphe pallidus.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16125857</pmid><doi>10.1016/j.neuroscience.2005.06.039</doi><tpages>12</tpages></addata></record> |
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| subjects | 2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Adipose Tissue, Brown - physiology Animals bicuculline Bicuculline - pharmacology Biological and medical sciences Carbon Dioxide - pharmacology dorsomedial hypothalamus Drug Interactions Electric Stimulation - methods Evoked Potentials - drug effects Evoked Potentials - physiology Evoked Potentials - radiation effects Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology Heart Rate - drug effects Hypothalamic Area, Lateral - cytology Hypothalamic Area, Lateral - drug effects Microinjections - methods Neural Inhibition - drug effects Neural Inhibition - physiology Neural Inhibition - radiation effects Neurons - drug effects Neurons - physiology orexin Raphe Nuclei - drug effects raphe pallidus Rats Rats, Sprague-Dawley sympathetic nerve activity Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Thermogenesis - physiology thermoregulation Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis |
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