lazaro Encodes a Lipid Phosphate Phosphohydrolase that Regulates Phosphatidylinositol Turnover during Drosophila Phototransduction

An essential step in Drosophila phototransduction is the hydrolysis of phosphatidylinositol 4,5 bisphosphate PI(4,5)P 2 by phospholipase Cβ (PLCβ) to generate a second messenger that opens the light-activated channels TRP and TRPL. Although the identity of this messenger remains unknown, recent evid...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2006-02, Vol.49 (4), p.533-546
Hauptverfasser:	Garcia-Murillas, Isaac, Pettitt, Trevor, Macdonald, Elaine, Okkenhaug, Hanneke, Georgiev, Plamen, Trivedi, Deepti, Hassan, Bassam, Wakelam, Michael, Raghu, Padinjat
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Genetically Modified Biosynthesis Blotting, Northern - methods Diacylglycerol Kinase - genetics Diacylglycerol Kinase - metabolism Drosophila Drosophila - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Electroretinography - methods Gene Expression - physiology Genomes Genotype & phenotype Humans Immunohistochemistry - methods Insects Kinases Light Lipid Metabolism - physiology Lipids Metabolites Microscopy, Electron - methods Molecular Biology - methods MOLNEURO Mutagenesis - physiology Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositols - metabolism Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Photoreceptor Cells, Invertebrate - physiology Photoreceptors Proteins Retina - metabolism Retinal Degeneration - genetics Retinal Degeneration - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Sequence Alignment SIGNALING Vision, Ocular - drug effects Vision, Ocular - physiology
Online-Zugang:	Volltext
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