Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System

HIV-1 infection of the brain results in chronic inflammation, contributing to the neuropathogenesis of HIV-1 associated neurologic disease. HIV-1-infected mononuclear phagocytes (MP) present in inflammatory infiltrates produce neurotoxins that mediate inflammation, dysfunction, and neuronal apoptosi...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-02, Vol.164 (3), p.1333-1339
Hauptverfasser:	Tong, Ning, Perry, Seth W, Zhang, Qing, James, Harold J, Guo, Huang, Brooks, Andrew, Bal, Harshawardhan, Kinnear, Sandra A, Fine, Steven, Epstein, Leon G, Dairaghi, Daniel, Schall, Thomas J, Gendelman, Howard E, Dewhurst, Stephen, Sharer, Leroy R, Gelbard2, Harris A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Astrocytes - immunology Brain - immunology Brain - metabolism Brain - pathology Cell Movement - immunology Cells, Cultured Chemokine CX3CL1 Chemokines, CX3C - administration & dosage Chemokines, CX3C - biosynthesis Chemokines, CX3C - physiology Child Cytoplasm - metabolism Encephalitis, Viral - immunology Encephalitis, Viral - pathology Endothelium, Vascular - immunology fractalkine Gene Products, tat - administration & dosage HIV Infections - immunology HIV Infections - pathology HIV Seronegativity - immunology HIV-1 - immunology Human immunodeficiency virus 1 Humans Macrophage Activation - immunology Male Membrane Proteins - administration & dosage Membrane Proteins - biosynthesis Membrane Proteins - physiology Microglia - metabolism Microglia - pathology Monocytes - immunology Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Platelet Activating Factor - administration & dosage Rats Rats, Sprague-Dawley tat Gene Products, Human Immunodeficiency Virus Up-Regulation - immunology
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