CD7 expression distinguishes subsets of CD4 super(+) T cells with distinct functional properties and ability to support replication of HIV-1
Enrichment of a subset of CD4 super(+)CD45R0 super(+)CD7 super(-)T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7 super(+) and CD7 super(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7 super(+) cells. Several...
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| Veröffentlicht in: | European journal of immunology 2000-02, Vol.30 (2), p.577-585 |
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| container_title | European journal of immunology |
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| creator | Wallace, D L Matear, P M Davies, D C Hicks, R Lebosse, C Eyeson, J Beverley, PCL Vyakarnam, A |
| description | Enrichment of a subset of CD4 super(+)CD45R0 super(+)CD7 super(-)T cells has been observed in HIV-infected individuals. We have investigated the ability of CD7 super(+) and CD7 super(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7 super(+) cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7 super(-) compared with CD7 super(+) cells. We also show that uninfected CD7 super(-) cells are more resistant to mitogen-induced apoptosis than CD7 super(+) cells. Our data support the view that the CD7 super(-) subset is inherently resistant to HIV replication and that this is due in part to reduced CD25 expression and IL-2 production. |
| doi_str_mv | 10.1002/1521-4141(200002)30:2<577::AID-IMMU577>3.3.CO;2-P |
| format | Article |
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We have investigated the ability of CD7 super(+) and CD7 super(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7 super(+) cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7 super(-) compared with CD7 super(+) cells. We also show that uninfected CD7 super(-) cells are more resistant to mitogen-induced apoptosis than CD7 super(+) cells. 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We have investigated the ability of CD7 super(+) and CD7 super(-) T cells to support replication of HIV and show that virus replicates preferentially in CD7 super(+) cells. Several possible mechanisms that may underlie such differences in susceptibility to HIV were studied. Our data demonstrate that mitogen stimulation induces poor expression of CD25 and IL-2 in CD7 super(-) compared with CD7 super(+) cells. We also show that uninfected CD7 super(-) cells are more resistant to mitogen-induced apoptosis than CD7 super(+) cells. Our data support the view that the CD7 super(-) subset is inherently resistant to HIV replication and that this is due in part to reduced CD25 expression and IL-2 production.</description><subject>CD25 antigen</subject><subject>CD4 antigen</subject><subject>CD7 antigen</subject><subject>human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><issn>0014-2980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNjU1OwzAQRr0AifJzh1mhVsjBdpyGBIRUJaBmUcGisK3c1KFGJg4ZR8AdODSO1AMwixl90vveEJJxFnHGxDVPBKeSSz4VLIyYxSwXd0ma5vmiKmm1Wr2EcB9HcVQ83Qr6fEQmjHFJRXbDTsgp4nuoZfMkm5DfokxBf3e9RjSuhZ1Bb9q3weBeI-CwRe0RXANFKUPsdD-9msEaam0twpfx-0Ol9tAMYQeJstD1LqDeBIdqd6C2xhr_A96Njs71HnrdWVOrkR_1y-qV8nNy3CiL-uJwz8jl48O6WNKg-xw0-s2HwfGzarUbcMNTmcq5ZPG_wT-_OmOE</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Wallace, D L</creator><creator>Matear, P M</creator><creator>Davies, D C</creator><creator>Hicks, R</creator><creator>Lebosse, C</creator><creator>Eyeson, J</creator><creator>Beverley, PCL</creator><creator>Vyakarnam, A</creator><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20000201</creationdate><title>CD7 expression distinguishes subsets of CD4 super(+) T cells with distinct functional properties and ability to support replication of HIV-1</title><author>Wallace, D L ; Matear, P M ; Davies, D C ; Hicks, R ; Lebosse, C ; Eyeson, J ; Beverley, PCL ; Vyakarnam, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_174746403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>CD25 antigen</topic><topic>CD4 antigen</topic><topic>CD7 antigen</topic><topic>human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, D L</creatorcontrib><creatorcontrib>Matear, P M</creatorcontrib><creatorcontrib>Davies, D C</creatorcontrib><creatorcontrib>Hicks, R</creatorcontrib><creatorcontrib>Lebosse, C</creatorcontrib><creatorcontrib>Eyeson, J</creatorcontrib><creatorcontrib>Beverley, PCL</creatorcontrib><creatorcontrib>Vyakarnam, A</creatorcontrib><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, D L</au><au>Matear, P M</au><au>Davies, D C</au><au>Hicks, R</au><au>Lebosse, C</au><au>Eyeson, J</au><au>Beverley, PCL</au><au>Vyakarnam, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD7 expression distinguishes subsets of CD4 super(+) T cells with distinct functional properties and ability to support replication of HIV-1</atitle><jtitle>European journal of immunology</jtitle><date>2000-02-01</date><risdate>2000</risdate><volume>30</volume><issue>2</issue><spage>577</spage><epage>585</epage><pages>577-585</pages><issn>0014-2980</issn><abstract>Enrichment of a subset of CD4 super(+)CD45R0 super(+)CD7 super(-)T cells has been observed in HIV-infected individuals. 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| ispartof | European journal of immunology, 2000-02, Vol.30 (2), p.577-585 |
| issn | 0014-2980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17474640 |
| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | CD25 antigen CD4 antigen CD7 antigen human immunodeficiency virus Human immunodeficiency virus 1 |
| title | CD7 expression distinguishes subsets of CD4 super(+) T cells with distinct functional properties and ability to support replication of HIV-1 |
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