p8 Is a New Target of Gemcitabine in Pancreatic Cancer Cells

Gemcitabine is the only available chemotherapeutic treatment of pancreatic cancers. It is, however, moderately effective, showing a tumor response rate of only 12%. The aim of this work was to identify new pathways involved in the resistance of pancreatic cancer cells to gemcitabine, in the hope of...

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (1), p.235-241
Hauptverfasser:	GIROUX, Valentin, MALICET, Cédric, BARTHET, Marc, GIRONELLA, Meritxell, ARCHANGE, Cendrine, DAGORN, Jean-Charles, VASSEUR, Sophie, IOVANNA, Juan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Antineoplastic agents Apoptosis - drug effects Basic Helix-Loop-Helix Transcription Factors - drug effects Basic Helix-Loop-Helix Transcription Factors - metabolism Biological and medical sciences Caspase 3 Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Resistance, Neoplasm - genetics Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen gemcitabine Gene Expression Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences microarray Neoplasm Proteins - drug effects Neoplasm Proteins - metabolism Oligonucleotide Array Sequence Analysis pancreas cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis siRNA Tumors
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