Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer
Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adi...
Gespeichert in:
| Veröffentlicht in: | Tumor biology 2015-11, Vol.36 (11), p.8685-8695 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8695 |
|---|---|
| container_issue | 11 |
| container_start_page | 8685 |
| container_title | Tumor biology |
| container_volume | 36 |
| creator | Jung, Yoon Yang Lee, Yu Kyung Koo, Ja Seung |
| description | Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adipose stroma. The status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67, podoplanin, prolyl 4-hydroxylase, fibroblast activation protein α (FAPα), S100A4, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, and chondroitin sulfate proteoglycan (NG2) was evaluated via tissue microarrays. Tumors were divided into luminal A, luminal B, HER-2, or triple-negative breast cancer subtypes according to their molecular status. Luminal A subtype was more prevalent in breast cancer of adipose stroma type, whereas other molecular subtypes were more common in fibrous stroma type (
p
|
| doi_str_mv | 10.1007/s13277-015-3594-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1747331621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3897216971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-e602c212e30e5888c9fd72100d7153dadd4128d7ab294551558e9b08da8ddc443</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVJaL76A3ophlx6UTP6sqVjCWlSCPSSXCNkaVwcvNZW44Xk30fb3YYQ6EmD9MyjmZexzwK-CYDugoSSXcdBGK6M09x9YMdCS8VBWTioNQjgWlp1xE6IHqGCzrUf2ZFsQWvTymP2cPW0Lkg05rnJQxPDHLHwQJTjGBZMzTD2JfdToIUXnP5erUtecJypGecmpHGdCRtaSl6FraIvWOG96YwdDmEi_LQ_T9n9j6u7yxt---v65-X3Wx4N2IVjCzJKIVEBGmttdEPqZN0xdcKoFFLSQtrUhV46bYwwxqLrwaZgU4paq1P2deets_3ZIC1-NVLEaQoz5g150elOKdFKUdHzd-hj3pS5TrelXAvKAFRK7KhYMlHBwa_LuArl2Qvw2_D9LnxfM_Xb8L2rPV_25k2_wvTa8S_tCsgdQPVp_o3lzdf_tb4AJ2iPAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749603500</pqid></control><display><type>article</type><title>Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Jung, Yoon Yang ; Lee, Yu Kyung ; Koo, Ja Seung</creator><creatorcontrib>Jung, Yoon Yang ; Lee, Yu Kyung ; Koo, Ja Seung</creatorcontrib><description>Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adipose stroma. The status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67, podoplanin, prolyl 4-hydroxylase, fibroblast activation protein α (FAPα), S100A4, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, and chondroitin sulfate proteoglycan (NG2) was evaluated via tissue microarrays. Tumors were divided into luminal A, luminal B, HER-2, or triple-negative breast cancer subtypes according to their molecular status. Luminal A subtype was more prevalent in breast cancer of adipose stroma type, whereas other molecular subtypes were more common in fibrous stroma type (
p
< 0.001). Tumor cell expression of podoplanin and FAPα was higher in adipose stroma type, while higher expression of prolyl 4-hydroxylase and PDGFRα was observed in fibrous stroma type. Furthermore, adipose stroma type exhibited higher stromal expression of podoplanin, FAPα, PDGFRβ, and NG2, whereas fibrous stroma type had higher prolyl 4-hydroxylase and S100A4 expression. In adipose stroma type, tumor positivity (
p
= 0.034) and stromal positivity (
p
= 0.005) of prolyl 4-hydroxylase were associated with shorter disease-free survival, and stromal prolyl 4-hydroxylase positivity was with shorter overall survival (
p
< 0.001). In conclusion, expression of CAF-related proteins was observed in breast cancer, with different profiles between adipose and fibrous stroma types. Prolyl 4-hydrolase status might be of prognostic value in adipose stroma type.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-3594-9</identifier><identifier>PMID: 26044562</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Adult ; Aged ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Cancer Research ; Disease-Free Survival ; Female ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Proteins ; Receptor, ErbB-2 - genetics ; Research Article ; Stromal Cells - metabolism ; Stromal Cells - pathology ; Studies ; Triple Negative Breast Neoplasms - genetics ; Triple Negative Breast Neoplasms - pathology ; Tumor Microenvironment - genetics ; Tumors</subject><ispartof>Tumor biology, 2015-11, Vol.36 (11), p.8685-8695</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-e602c212e30e5888c9fd72100d7153dadd4128d7ab294551558e9b08da8ddc443</citedby><cites>FETCH-LOGICAL-c508t-e602c212e30e5888c9fd72100d7153dadd4128d7ab294551558e9b08da8ddc443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-015-3594-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-015-3594-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26044562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Yoon Yang</creatorcontrib><creatorcontrib>Lee, Yu Kyung</creatorcontrib><creatorcontrib>Koo, Ja Seung</creatorcontrib><title>Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adipose stroma. The status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67, podoplanin, prolyl 4-hydroxylase, fibroblast activation protein α (FAPα), S100A4, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, and chondroitin sulfate proteoglycan (NG2) was evaluated via tissue microarrays. Tumors were divided into luminal A, luminal B, HER-2, or triple-negative breast cancer subtypes according to their molecular status. Luminal A subtype was more prevalent in breast cancer of adipose stroma type, whereas other molecular subtypes were more common in fibrous stroma type (
p
< 0.001). Tumor cell expression of podoplanin and FAPα was higher in adipose stroma type, while higher expression of prolyl 4-hydroxylase and PDGFRα was observed in fibrous stroma type. Furthermore, adipose stroma type exhibited higher stromal expression of podoplanin, FAPα, PDGFRβ, and NG2, whereas fibrous stroma type had higher prolyl 4-hydroxylase and S100A4 expression. In adipose stroma type, tumor positivity (
p
= 0.034) and stromal positivity (
p
= 0.005) of prolyl 4-hydroxylase were associated with shorter disease-free survival, and stromal prolyl 4-hydroxylase positivity was with shorter overall survival (
p
< 0.001). In conclusion, expression of CAF-related proteins was observed in breast cancer, with different profiles between adipose and fibrous stroma types. Prolyl 4-hydrolase status might be of prognostic value in adipose stroma type.</description><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Cancer Research</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - pathology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Proteins</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Research Article</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Studies</subject><subject>Triple Negative Breast Neoplasms - genetics</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><subject>Tumor Microenvironment - genetics</subject><subject>Tumors</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1r3DAQhkVJaL76A3ophlx6UTP6sqVjCWlSCPSSXCNkaVwcvNZW44Xk30fb3YYQ6EmD9MyjmZexzwK-CYDugoSSXcdBGK6M09x9YMdCS8VBWTioNQjgWlp1xE6IHqGCzrUf2ZFsQWvTymP2cPW0Lkg05rnJQxPDHLHwQJTjGBZMzTD2JfdToIUXnP5erUtecJypGecmpHGdCRtaSl6FraIvWOG96YwdDmEi_LQ_T9n9j6u7yxt---v65-X3Wx4N2IVjCzJKIVEBGmttdEPqZN0xdcKoFFLSQtrUhV46bYwwxqLrwaZgU4paq1P2deets_3ZIC1-NVLEaQoz5g150elOKdFKUdHzd-hj3pS5TrelXAvKAFRK7KhYMlHBwa_LuArl2Qvw2_D9LnxfM_Xb8L2rPV_25k2_wvTa8S_tCsgdQPVp_o3lzdf_tb4AJ2iPAA</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Jung, Yoon Yang</creator><creator>Lee, Yu Kyung</creator><creator>Koo, Ja Seung</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer</title><author>Jung, Yoon Yang ; Lee, Yu Kyung ; Koo, Ja Seung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-e602c212e30e5888c9fd72100d7153dadd4128d7ab294551558e9b08da8ddc443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Cancer Research</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - pathology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Proteins</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Research Article</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Studies</topic><topic>Triple Negative Breast Neoplasms - genetics</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><topic>Tumor Microenvironment - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Yoon Yang</creatorcontrib><creatorcontrib>Lee, Yu Kyung</creatorcontrib><creatorcontrib>Koo, Ja Seung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Yoon Yang</au><au>Lee, Yu Kyung</au><au>Koo, Ja Seung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>36</volume><issue>11</issue><spage>8685</spage><epage>8695</epage><pages>8685-8695</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adipose stroma. The status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67, podoplanin, prolyl 4-hydroxylase, fibroblast activation protein α (FAPα), S100A4, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, and chondroitin sulfate proteoglycan (NG2) was evaluated via tissue microarrays. Tumors were divided into luminal A, luminal B, HER-2, or triple-negative breast cancer subtypes according to their molecular status. Luminal A subtype was more prevalent in breast cancer of adipose stroma type, whereas other molecular subtypes were more common in fibrous stroma type (
p
< 0.001). Tumor cell expression of podoplanin and FAPα was higher in adipose stroma type, while higher expression of prolyl 4-hydroxylase and PDGFRα was observed in fibrous stroma type. Furthermore, adipose stroma type exhibited higher stromal expression of podoplanin, FAPα, PDGFRβ, and NG2, whereas fibrous stroma type had higher prolyl 4-hydroxylase and S100A4 expression. In adipose stroma type, tumor positivity (
p
= 0.034) and stromal positivity (
p
= 0.005) of prolyl 4-hydroxylase were associated with shorter disease-free survival, and stromal prolyl 4-hydroxylase positivity was with shorter overall survival (
p
< 0.001). In conclusion, expression of CAF-related proteins was observed in breast cancer, with different profiles between adipose and fibrous stroma types. Prolyl 4-hydrolase status might be of prognostic value in adipose stroma type.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26044562</pmid><doi>10.1007/s13277-015-3594-9</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1010-4283 |
| ispartof | Tumor biology, 2015-11, Vol.36 (11), p.8685-8695 |
| issn | 1010-4283 1423-0380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1747331621 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adipose Tissue - metabolism Adipose Tissue - pathology Adult Aged Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Disease-Free Survival Female Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation, Neoplastic Humans Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Proteins Receptor, ErbB-2 - genetics Research Article Stromal Cells - metabolism Stromal Cells - pathology Studies Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor Microenvironment - genetics Tumors |
| title | Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T12%3A58%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20cancer-associated%20fibroblast-related%20proteins%20in%20adipose%20stroma%20of%20breast%20cancer&rft.jtitle=Tumor%20biology&rft.au=Jung,%20Yoon%20Yang&rft.date=2015-11-01&rft.volume=36&rft.issue=11&rft.spage=8685&rft.epage=8695&rft.pages=8685-8695&rft.issn=1010-4283&rft.eissn=1423-0380&rft_id=info:doi/10.1007/s13277-015-3594-9&rft_dat=%3Cproquest_cross%3E3897216971%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1749603500&rft_id=info:pmid/26044562&rfr_iscdi=true |