Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease

The potential for serum amyloid P-component (SAP) to prevent cardiac remodeling and identify worsening diastolic dysfunction (DD) was investigated. The anti-fibrotic potential of SAP was tested in an animal model of hypertensive heart disease (spontaneously hypertensive rats treated with SAP [SHR − ...

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Veröffentlicht in:	Journal of cardiovascular translational research 2015-12, Vol.8 (9), p.554-566
Hauptverfasser:	Horgan, Stephen J., Watson, Chris J., Glezeva, Nadia, Collier, Pat, Neary, Roisin, Tea, Isaac J., Corrigan, Niamh, Ledwidge, Mark, McDonald, Ken, Baugh, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical Engineering and Bioengineering Biomedicine Biopsy, Needle Cardiology Cells, Cultured Disease Models, Animal Human Genetics Humans Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Hypertrophy, Left Ventricular - drug therapy Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - pathology Immunohistochemistry Macrophages - drug effects Macrophages - metabolism Male Medicine Medicine & Public Health Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Random Allocation Rats, Inbred SHR Rats, Inbred WKY Reference Values Serum Amyloid P-Component - administration & dosage Ventricular Remodeling - drug effects
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Zusammenfassung:	The potential for serum amyloid P-component (SAP) to prevent cardiac remodeling and identify worsening diastolic dysfunction (DD) was investigated. The anti-fibrotic potential of SAP was tested in an animal model of hypertensive heart disease (spontaneously hypertensive rats treated with SAP [SHR − SAP] × 12 weeks). Biomarker analysis included a prospective study of 60 patients with asymptomatic progressive DD. Compared with vehicle-treated Wistar-Kyoto rats (WKY-V), the vehicle-treated SHRs (SHR-V) exhibited significant increases in left ventricular mass, perivascular collagen, cardiomyocyte size, and macrophage infiltration. SAP administration was associated with significantly lower left ventricular mass ( p
ISSN:	1937-5387 1937-5395
DOI:	10.1007/s12265-015-9661-1