Gut Microbiota Interacts With Brain Microstructure and Function
Context: Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce. Objective: This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subject...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2015-12, Vol.100 (12), p.4505-4513 |
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| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 100 |
| creator | Fernandez-Real, José-Manuel Serino, Matteo Blasco, Gerard Puig, Josep Daunis-i-Estadella, Josep Ricart, Wifredo Burcelin, Remy Fernández-Aranda, Fernando Portero-Otin, Manuel |
| description | Context:
Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce.
Objective:
This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects.
Design, Setting, and Participants:
This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex.
Main Outcome Measures:
Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests.
Results:
Hierarchical clustering revealed a specific gut microbiota–brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility.
Conclusions:
In sum, obesity status affects microbiota–brain microstructure and function crosstalk. |
| doi_str_mv | 10.1210/jc.2015-3076 |
| format | Article |
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Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce.
Objective:
This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects.
Design, Setting, and Participants:
This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex.
Main Outcome Measures:
Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests.
Results:
Hierarchical clustering revealed a specific gut microbiota–brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility.
Conclusions:
In sum, obesity status affects microbiota–brain microstructure and function crosstalk.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2015-3076</identifier><identifier>PMID: 26445114</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Actinobacteria ; Adult ; Aged ; Attention - physiology ; Biodiversity ; Body Composition - physiology ; Brain - physiology ; Brain - ultrastructure ; Cognition ; Cross-Sectional Studies ; Diffusion Tensor Imaging ; Female ; Humans ; Male ; Microbiota - physiology ; Middle Aged ; Neuropsychological Tests ; Obesity - microbiology ; Obesity - psychology ; Reaction Time - physiology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2015-12, Vol.100 (12), p.4505-4513</ispartof><rights>Copyright © 2015 by the Endocrine Society</rights><rights>Copyright © 2015 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4186-e94c75fa2f9ad7d7cc4bd3f9e76a70ab716148225c33bb825e112592c72f500c3</citedby><cites>FETCH-LOGICAL-c4186-e94c75fa2f9ad7d7cc4bd3f9e76a70ab716148225c33bb825e112592c72f500c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26445114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandez-Real, José-Manuel</creatorcontrib><creatorcontrib>Serino, Matteo</creatorcontrib><creatorcontrib>Blasco, Gerard</creatorcontrib><creatorcontrib>Puig, Josep</creatorcontrib><creatorcontrib>Daunis-i-Estadella, Josep</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Burcelin, Remy</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Portero-Otin, Manuel</creatorcontrib><title>Gut Microbiota Interacts With Brain Microstructure and Function</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce.
Objective:
This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects.
Design, Setting, and Participants:
This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex.
Main Outcome Measures:
Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests.
Results:
Hierarchical clustering revealed a specific gut microbiota–brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility.
Conclusions:
In sum, obesity status affects microbiota–brain microstructure and function crosstalk.</description><subject>Actinobacteria</subject><subject>Adult</subject><subject>Aged</subject><subject>Attention - physiology</subject><subject>Biodiversity</subject><subject>Body Composition - physiology</subject><subject>Brain - physiology</subject><subject>Brain - ultrastructure</subject><subject>Cognition</subject><subject>Cross-Sectional Studies</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiota - physiology</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Obesity - microbiology</subject><subject>Obesity - psychology</subject><subject>Reaction Time - physiology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAUx4Mobk5vnqVHD3bmpWmznkSHm4OJF0VvIU1T1tqlMz8Y_vemdHoy8EjC-7wvjw9Cl4CnQADfNnJKMKRxgll2hMaQ0zRmkLNjNMaYQJwz8jFCZ9Y2GAOlaXKKRiQLDwA6RndL76LnWpquqDsnopV2ygjpbPReu030YESth751xkvnjYqELqOF19LVnT5HJ5Vorbo43BP0tnh8nT_F65flan6_jiWFWRarnEqWVoJUuShZyaSkRZlUuWKZYFgUDDKgM0JSmSRFMSOpAiBpTiQjVYqxTCboesjdme7LK-v4trZSta3QqvOWA6MsITmmWUBvBrRf2hpV8Z2pt8J8c8C8V8YbyXtlvFcW8KtDsi-2qvyDfx0FgA7AvmuDHPvZ-r0yfKNE6zYch0MzNov7RCDhF4eCPjcZxpQuO2lqrXZGWcubzhsdVP2_zQ_zR4Zs</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Fernandez-Real, José-Manuel</creator><creator>Serino, Matteo</creator><creator>Blasco, Gerard</creator><creator>Puig, Josep</creator><creator>Daunis-i-Estadella, Josep</creator><creator>Ricart, Wifredo</creator><creator>Burcelin, Remy</creator><creator>Fernández-Aranda, Fernando</creator><creator>Portero-Otin, Manuel</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Gut Microbiota Interacts With Brain Microstructure and Function</title><author>Fernandez-Real, José-Manuel ; Serino, Matteo ; Blasco, Gerard ; Puig, Josep ; Daunis-i-Estadella, Josep ; Ricart, Wifredo ; Burcelin, Remy ; Fernández-Aranda, Fernando ; Portero-Otin, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4186-e94c75fa2f9ad7d7cc4bd3f9e76a70ab716148225c33bb825e112592c72f500c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Actinobacteria</topic><topic>Adult</topic><topic>Aged</topic><topic>Attention - physiology</topic><topic>Biodiversity</topic><topic>Body Composition - physiology</topic><topic>Brain - physiology</topic><topic>Brain - ultrastructure</topic><topic>Cognition</topic><topic>Cross-Sectional Studies</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microbiota - physiology</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Obesity - microbiology</topic><topic>Obesity - psychology</topic><topic>Reaction Time - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandez-Real, José-Manuel</creatorcontrib><creatorcontrib>Serino, Matteo</creatorcontrib><creatorcontrib>Blasco, Gerard</creatorcontrib><creatorcontrib>Puig, Josep</creatorcontrib><creatorcontrib>Daunis-i-Estadella, Josep</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Burcelin, Remy</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Portero-Otin, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandez-Real, José-Manuel</au><au>Serino, Matteo</au><au>Blasco, Gerard</au><au>Puig, Josep</au><au>Daunis-i-Estadella, Josep</au><au>Ricart, Wifredo</au><au>Burcelin, Remy</au><au>Fernández-Aranda, Fernando</au><au>Portero-Otin, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut Microbiota Interacts With Brain Microstructure and Function</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2015-12</date><risdate>2015</risdate><volume>100</volume><issue>12</issue><spage>4505</spage><epage>4513</epage><pages>4505-4513</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Context:
Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce.
Objective:
This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects.
Design, Setting, and Participants:
This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex.
Main Outcome Measures:
Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests.
Results:
Hierarchical clustering revealed a specific gut microbiota–brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility.
Conclusions:
In sum, obesity status affects microbiota–brain microstructure and function crosstalk.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>26445114</pmid><doi>10.1210/jc.2015-3076</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2015-12, Vol.100 (12), p.4505-4513 |
| issn | 0021-972X 1945-7197 |
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| source | Oxford University Press Journals; MEDLINE; EZB Free E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Actinobacteria Adult Aged Attention - physiology Biodiversity Body Composition - physiology Brain - physiology Brain - ultrastructure Cognition Cross-Sectional Studies Diffusion Tensor Imaging Female Humans Male Microbiota - physiology Middle Aged Neuropsychological Tests Obesity - microbiology Obesity - psychology Reaction Time - physiology |
| title | Gut Microbiota Interacts With Brain Microstructure and Function |
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