Oxygen-induced mitochondrial biogenesis in the rat hippocampus

The hypothesis that damage to mitochondrial DNA by reactive oxygen species increases the activity of nuclear and mitochondrial transcription factors for mitochondrial DNA replication was tested in the in vivo rat brain. Mitochondrial reactive oxygen species generation was stimulated using pre-convul...

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Veröffentlicht in:	Neuroscience 2006, Vol.137 (2), p.493-504
Hauptverfasser:	Gutsaeva, D.R., Suliman, H.B., Carraway, M.S., Demchenko, I.T., Piantadosi, C.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Shape - drug effects Cell Shape - physiology DNA Replication - drug effects DNA Replication - physiology DNA, Mitochondrial - drug effects DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Electron Transport - drug effects Electron Transport - genetics GA-Binding Protein Transcription Factor - drug effects GA-Binding Protein Transcription Factor - metabolism Gene Deletion Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - physiology Hippocampus - drug effects Hippocampus - metabolism hyperbaric oxygen Male mitochondria Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism mitochondrial biogenesis mtDNA deletion Neurons - drug effects Neurons - metabolism Nitric Oxide Synthase Type I - drug effects Nitric Oxide Synthase Type I - metabolism Nuclear Respiratory Factor 1 - drug effects Nuclear Respiratory Factor 1 - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Oxygen - metabolism Oxygen - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Reactive Oxygen Species - pharmacology Transcription Factors - drug effects Transcription Factors - metabolism Transcriptional Activation - drug effects Transcriptional Activation - physiology Up-Regulation - drug effects Up-Regulation - physiology
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