Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study

The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer) study has demonstrated 3-year disease-free survival (DFS) and 6-year overall survival (OS) benefit of adjuvant oxaliplatin in stage II to III resected colon cancer. This upda...

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Veröffentlicht in:	Journal of clinical oncology 2015-12, Vol.33 (35), p.4176-4187
Hauptverfasser:	André, Thierry, de Gramont, Armand, Vernerey, Dewi, Chibaudel, Benoist, Bonnetain, Franck, Tijeras-Raballand, Annemilaï, Scriva, Aurelie, Hickish, Tamas, Tabernero, Josep, Van Laethem, Jean Luc, Banzi, Maria, Maartense, Eduard, Shmueli, Einat, Carlsson, Goran U, Scheithauer, Werner, Papamichael, Demetris, Möehler, Marcus, Landolfi, Stefania, Demetter, Pieter, Colote, Soudhir, Tournigand, Christophe, Louvet, Christophe, Duval, Alex, Fléjou, Jean-François, de Gramont, Aimery
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemotherapy, Adjuvant Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - mortality Colonic Neoplasms - pathology Disease-Free Survival DNA Mismatch Repair Female Fluorouracil - administration & dosage Follow-Up Studies Glutamic Acid Humans Infusions, Intravenous Injections, Intravenous Kaplan-Meier Estimate Leucovorin - administration & dosage Male Middle Aged Mutation Neoplasm Staging Odds Ratio Organoplatinum Compounds - administration & dosage Prognosis Proto-Oncogene Proteins B-raf - genetics Treatment Outcome Valine
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