Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

Although surface PEGylation of siRNA vectors is effective for preventing protein adsorption and thereby helps these vectors to evade the reticuloendothelial system (RES) in vivo, it also suppresses the cellular uptake of these vectors by target cells. This dilemma could be overcome by employing stim...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-12, Vol.137 (48), p.15217-15224
Hauptverfasser:	Sun, Chun-Yang, Shen, Song, Xu, Cong-Fei, Li, Hong-Jun, Liu, Yang, Cao, Zhi-Ting, Yang, Xian-Zhu, Xia, Jin-Xing, Wang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Micelles Neoplasms - metabolism Polymers - chemistry RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacokinetics Tissue Distribution
Online-Zugang:	Volltext
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