S-(−)-Dinitrobiphenic Acid:  A Selective Inhibitor of Escherichia coli Chorismate Mutase Based on Prephenate Mimicry

The conversion of chorismate 1 to prephenate 2 in the shikimate biosynthetic pathway is catalyzed by the enzyme chorismate mutase (CM) and represents a rare example of an enzyme-catalyzed pericyclic reaction. X-ray crystallographic analyses of CMs have identified two distinct protein folds that cata...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-03, Vol.121 (11), p.2647-2648
Hauptverfasser:	Husain, Arifa, Galopin, Christophe C, Zhang, Sheng, Pohnert, Georg, Ganem, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Escherichia coli oxabicyclic diacid 3 prephenic acid S-Dinitrobiphenic acid
Online-Zugang:	Volltext
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