Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study
Background Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy. Methods Japanese outpatients with symptomatic GERD...
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| Veröffentlicht in: | Journal of gastroenterology 2015-12, Vol.50 (12), p.1173-1183 |
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| creator | Matsuhashi, Nobuyuki Kudo, Mineo Yoshida, Norimasa Murakami, Kazunari Kato, Mototsugu Sanuki, Tsuyoshi Oshio, Atsushi Joh, Takashi Higuchi, Kazuhide Haruma, Ken Nakada, Koji |
| description | Background
Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.
Methods
Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.
Results
Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (
p
|
| doi_str_mv | 10.1007/s00535-015-1073-0 |
| format | Article |
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Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.
Methods
Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.
Results
Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (
p
< 0.05), absence of erosive esophagitis (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.05), and higher depression subscale score (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the patient’s impression of therapy, lower GERD symptom score (
p
< 0.05) and absence of erosive esophagitis (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the relative GERD symptom intensity evaluated using a numeric rating scale, lower GERD symptom score (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.1), and lower body mass index (
p
< 0.05) accompanied poorer therapeutic response.
Conclusions
Patients who complained of milder GERD symptoms before treatment were likely to have poorer response to PPI therapy. Association of absence of erosive esophagitis, severer epigastric pain/burning symptoms, lower body mass index, and severer depression with poorer therapeutic response was also suggested.]]></description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-015-1073-0</identifier><identifier>PMID: 25851931</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Age Distribution ; Aged ; Anxiety - psychology ; Colorectal Surgery ; Depression - psychology ; Dyspepsia - drug therapy ; Female ; Gastroenterology ; Gastroesophageal Reflux - drug therapy ; Gastrointestinal agents ; Health aspects ; Hepatology ; Humans ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Original Article—Alimentary Tract ; Patient Satisfaction ; Prospective Studies ; Proton Pump Inhibitors - therapeutic use ; Severity of Illness Index ; Sex Distribution ; Surgical Oncology ; Surveys ; Treatment Outcome</subject><ispartof>Journal of gastroenterology, 2015-12, Vol.50 (12), p.1173-1183</ispartof><rights>Springer Japan 2015</rights><rights>COPYRIGHT 2015 Springer</rights><rights>Japanese Society of Gastroenterology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-a46044d6c12a28669fe790c247c8a3446904827d9529e24ac107df112ae4f6f03</citedby><cites>FETCH-LOGICAL-c533t-a46044d6c12a28669fe790c247c8a3446904827d9529e24ac107df112ae4f6f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-015-1073-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-015-1073-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25851931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><creatorcontrib>Kudo, Mineo</creatorcontrib><creatorcontrib>Yoshida, Norimasa</creatorcontrib><creatorcontrib>Murakami, Kazunari</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Sanuki, Tsuyoshi</creatorcontrib><creatorcontrib>Oshio, Atsushi</creatorcontrib><creatorcontrib>Joh, Takashi</creatorcontrib><creatorcontrib>Higuchi, Kazuhide</creatorcontrib><creatorcontrib>Haruma, Ken</creatorcontrib><creatorcontrib>Nakada, Koji</creatorcontrib><title>Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description><![CDATA[Background
Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.
Methods
Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.
Results
Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (
p
< 0.05), absence of erosive esophagitis (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.05), and higher depression subscale score (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the patient’s impression of therapy, lower GERD symptom score (
p
< 0.05) and absence of erosive esophagitis (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the relative GERD symptom intensity evaluated using a numeric rating scale, lower GERD symptom score (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.1), and lower body mass index (
p
< 0.05) accompanied poorer therapeutic response.
Conclusions
Patients who complained of milder GERD symptoms before treatment were likely to have poorer response to PPI therapy. Association of absence of erosive esophagitis, severer epigastric pain/burning symptoms, lower body mass index, and severer depression with poorer therapeutic response was also suggested.]]></description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Anxiety - psychology</subject><subject>Colorectal Surgery</subject><subject>Depression - psychology</subject><subject>Dyspepsia - drug therapy</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastrointestinal agents</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Original Article—Alimentary Tract</subject><subject>Patient Satisfaction</subject><subject>Prospective Studies</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Severity of Illness Index</subject><subject>Sex Distribution</subject><subject>Surgical Oncology</subject><subject>Surveys</subject><subject>Treatment Outcome</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1ks1u1DAUhSMEokPhAdggS2y6SbEdO4nZVRUFpEpsYG15nOsZV4kdbKcwz8LL9oYpvwJ5YenmO8c3R6eqnjN6zijtXmVKZSNrymTNaNfU9EG1YQInUnH-sNpQJUTNWCdOqic531DKGir7x9UJl71kqmGb6tuVsSWmTIxzYIsPO5IgzzFkICWSOcUSA5mXaSY-7P3WI0zKHpKZDzghsykeQsnkiy97sjO5pAg5znuzAzOilxuXr2TwGUyG18SQaRmLtyiBtLrneX31FkjcZki36BYD6nJZhsPT6pEzY4Zn9_dp9enqzcfLd_X1h7fvLy-uayubptRGtFSIobWMG963rXLQKWq56GxvGiFaRUXPu0FJroALYzGrwTGkQbjW0ea0Ojv64j6fF8hFTz5bGEcTIC5ZY4AdBsdVi-jLv9CbuCTc-DulWoqPNb-onRlB--BiScaupvqiY0L2DZJInf-DwjPA5G0M4DzO_xCwo8Bibhmj1XPyk0kHzaheC6GPhdBYCL0WQq-aF_cLL9sJhp-KHw1AgB-BjJ_CDtJvf_Rf1zt4eMIH</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Matsuhashi, Nobuyuki</creator><creator>Kudo, Mineo</creator><creator>Yoshida, Norimasa</creator><creator>Murakami, Kazunari</creator><creator>Kato, Mototsugu</creator><creator>Sanuki, Tsuyoshi</creator><creator>Oshio, Atsushi</creator><creator>Joh, Takashi</creator><creator>Higuchi, Kazuhide</creator><creator>Haruma, Ken</creator><creator>Nakada, Koji</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study</title><author>Matsuhashi, Nobuyuki ; Kudo, Mineo ; Yoshida, Norimasa ; Murakami, Kazunari ; Kato, Mototsugu ; Sanuki, Tsuyoshi ; Oshio, Atsushi ; Joh, Takashi ; Higuchi, Kazuhide ; Haruma, Ken ; Nakada, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-a46044d6c12a28669fe790c247c8a3446904827d9529e24ac107df112ae4f6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Anxiety - psychology</topic><topic>Colorectal Surgery</topic><topic>Depression - psychology</topic><topic>Dyspepsia - drug therapy</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastrointestinal agents</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Original Article—Alimentary Tract</topic><topic>Patient Satisfaction</topic><topic>Prospective Studies</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Severity of Illness Index</topic><topic>Sex Distribution</topic><topic>Surgical Oncology</topic><topic>Surveys</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuhashi, Nobuyuki</creatorcontrib><creatorcontrib>Kudo, Mineo</creatorcontrib><creatorcontrib>Yoshida, Norimasa</creatorcontrib><creatorcontrib>Murakami, Kazunari</creatorcontrib><creatorcontrib>Kato, Mototsugu</creatorcontrib><creatorcontrib>Sanuki, Tsuyoshi</creatorcontrib><creatorcontrib>Oshio, Atsushi</creatorcontrib><creatorcontrib>Joh, Takashi</creatorcontrib><creatorcontrib>Higuchi, Kazuhide</creatorcontrib><creatorcontrib>Haruma, Ken</creatorcontrib><creatorcontrib>Nakada, Koji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuhashi, Nobuyuki</au><au>Kudo, Mineo</au><au>Yoshida, Norimasa</au><au>Murakami, Kazunari</au><au>Kato, Mototsugu</au><au>Sanuki, Tsuyoshi</au><au>Oshio, Atsushi</au><au>Joh, Takashi</au><au>Higuchi, Kazuhide</au><au>Haruma, Ken</au><au>Nakada, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>50</volume><issue>12</issue><spage>1173</spage><epage>1183</epage><pages>1173-1183</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract><![CDATA[Background
Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy.
Methods
Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables.
Results
Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (
p
< 0.05), absence of erosive esophagitis (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.05), and higher depression subscale score (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the patient’s impression of therapy, lower GERD symptom score (
p
< 0.05) and absence of erosive esophagitis (
p
< 0.05) accompanied poorer therapeutic response. In analyses using the relative GERD symptom intensity evaluated using a numeric rating scale, lower GERD symptom score (
p
< 0.05), higher epigastric pain/burning symptom score (
p
< 0.1), and lower body mass index (
p
< 0.05) accompanied poorer therapeutic response.
Conclusions
Patients who complained of milder GERD symptoms before treatment were likely to have poorer response to PPI therapy. Association of absence of erosive esophagitis, severer epigastric pain/burning symptoms, lower body mass index, and severer depression with poorer therapeutic response was also suggested.]]></abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25851931</pmid><doi>10.1007/s00535-015-1073-0</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2015-12, Vol.50 (12), p.1173-1183 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1747305296 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Adult Age Distribution Aged Anxiety - psychology Colorectal Surgery Depression - psychology Dyspepsia - drug therapy Female Gastroenterology Gastroesophageal Reflux - drug therapy Gastrointestinal agents Health aspects Hepatology Humans Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Original Article—Alimentary Tract Patient Satisfaction Prospective Studies Proton Pump Inhibitors - therapeutic use Severity of Illness Index Sex Distribution Surgical Oncology Surveys Treatment Outcome |
| title | Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease: a multicenter prospective observational study |
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